Conserved Protein Domain Family
zpr1_rel

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TIGR00340: zpr1_rel 
ZPR1-related zinc finger protein
This model describes a strictly archaeal family homologous to the domain duplicated in the eukaryotic zinc-binding protein ZPR1. ZPR1 was shown experimentally to bind approximately two moles of zinc; each copy of the domain contains a putative zinc finger of the form CXXCX(25)CXXC. ZPR1 binds the tyrosine kinase domain of epidermal growth factor receptor, but is displaced by receptor activation and autophosphorylation after which it redistributes in part to the nucleus. The proteins described by this model by analogy may be suggested to play a role in signal transduction. A model ZPR1_znf (TIGR00310) has been created to describe the domain shared by this protein and ZPR1. [Unknown function, General]
Statistics
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PSSM-Id: 129440
View PSSM: TIGR00340
Aligned: 5 rows
Threshold Bit Score: 211.199
Threshold Setting Gi: 13541009
Created: 7-Oct-2014
Updated: 11-Oct-2014
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499169872  21 CPVCGG-KgTLKAIQFIHRIPYFGEVMESTVICEKCGYRSADVMILEEREPRVYEVRVENeKDLFTRVVRSKSGTIELEE 99
gi 499179896  10 CPVCGGeR-CMTAVTRVEKIPYFGEIMESVLICERCNYRSTDIICLEQKEPSRYIIEAGA-DTLNARVVKSQSATIRIPE 87
gi 499180746   4 CPSCG--R-ELRAVVSTYDVPFFGKVLLTSISCE-CGFRHADSVVLGEKDPVRYIIKINRe-NLFTKVIRSTSGTIRIPE 78
gi 499226312  17 CPVCKS-K-TLKAVDYLYNTPHTGKLVLSNWYCENCGYKFRDVKPYETREPKLVEMKIENeDDLSALVYRSAFAKIVIPE 94
gi 499218894  13 CPVCGS---LLYLLTYDTDIPYEGRISIYTYQCKKCMYRKTEVYQEEEKNPVRITLKIESpEDLKTLVYRSRKADIYIPE 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499169872 100 LGIKIEPGPAAEGFVSNIEGVLERAKEVLLMARDFKEqenDE-EAVKKIDELLKYIEEVKEGKKP-LTVRIMDPFGNSAL 177
gi 499179896  88 LGLKVEPGPRSAGYISNIEGVVERFEAALKTALNLFE---DD-ESKKKASKILEMLHEVREGVRK-VTVIIEDPFGQSFV 162
gi 499180746  79 IGVAIEPGPASQAFITNLEGVLDRVEGVVRTAMRWNS---DDeEKVRRCEWILERIRNTIDGDEE-LTLILEDPFGNSLI 154
gi 499226312  95 LGIEIEPAGMSQGYISTIEGILEILLDQVGNFCDKEC---ED------------RIRSAMEGKIK-FTLIIEDESGLSFI 158
gi 499218894  90 IEASIDSAEYANGEITTVEGIIYRIGEKLDLLSYDDE---EK-EAVK---EVRKKIDDIINGYFGsFTLIITDESGKSVI 162
                        170
                 ....*....|
gi 499169872 178 IGEKVKSRKL 187
gi 499179896 163 GHPRALKEKL 172
gi 499180746 155 VSDEAFKEIM 164
gi 499226312 159 KSEKASTRPL 168
gi 499218894 163 ESEKAITEKI 172
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