2GT3,3PIL


Conserved Protein Domain Family
msrA

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TIGR00401: msrA 
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methionine-S-sulfoxide reductase
This model describes peptide methionine sulfoxide reductase (MsrA), a repair enzyme for proteins that have been inactivated by oxidation. The enzyme from E. coli is coextensive with this model and has enzymatic activity. However, in all completed genomes in which this module is present, a second protein module, described in TIGR00357, is also found, and in several cases as part of the same polypeptide chain: N-terminal to this module in Helicobacter pylori and Haemophilus influenzae (as in PilB of Neisseria gonorrhoeae) but C-terminal to it in Treponema pallidum. PilB, containing both domains, has been shown to be important for the expression of adhesins in certain pathogens. [Protein fate, Protein modification and repair, Cellular processes, Adaptations to atypical conditions]
Statistics
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PSSM-Id: 129496
View PSSM: TIGR00401
Aligned: 9 rows
Threshold Bit Score: 243.504
Threshold Setting Gi: 323714532
Created: 7-Oct-2014
Updated: 23-Jan-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2GT3_A        44 EIAIFAMGCFWGVERLFW--QLPGVYSTAAGYTG---G---YTPNPT---YREVCSGDTGHAEAVRIVYDPSVISYEQLL 112
gi 2499565     2 KQIYFGGGCFWGTQKYFD--LIKGVQKTSVGYLN---S---NMKNPT---YEQVCSGQTNAVEAVFVEYDENKVSLNELI 70
gi 731458     17 KLITLACGCFWGTEHMYRkyLNDRIVDCKVGYANgeeS---KKDSPSsvsYKRVCGGDTDFAEVLQVSYNPKVITLRELT 93
gi 12230340   49 ETALFGLGCFWGAERKFW--QIPGVYSTAVGYAA---G---YTPNPT---YQEVCTGMTGHNEVVLVAFDPQQVSYDQLL 117
gi 12230335    8 EKATFGAGCFWGVEDAFR--KVDGVVSTRVGYMG---G---HLENPT---YEDVCTGLTGHAEVVEVTFDPDVVGYSDLL 76
gi 1709688     6 EIATFAGGCFWCMVKPFD--EQPGIEKVVSGYTG---G---HTENPT---YEEVCSETTGHREAVQITFHPDVFPYEKLL 74
gi 485836379  44 EIAIFAMGCFWGVERLFW--QLPGVYSTAAGYTG---G---YTPNPT---YREVCSGDTGHAEAVRIVYDPSVISYEQLL 112
gi 1351572     2 KEIYFGGGCFWGIEKYFQ--LIKGVKKTSVGYLN---S---RIRNPS---YEQVCSGYTNAVEAVKVEYEEKEISLSELI 70
3PIL_A        17 KLITLACGCFWGTEHMYRkyLNDRIVDCKVGYAN---GeesKKDSPSsvsYKRVCGGDTDFAEVLQVSYNPKVITLRELT 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2GT3_A       113 QVFWENHDPAQGMRQGNDHGTQYRSAIYPLTPEQDAAARASLERFQAamlaaDDDRHITTEIANATPFYYAEDDHQQYLH 192
gi 2499565    71 DAFFKVIDPTIRNRQGNDIGTQYRTGVYWVDPQDEQLITQKFRELQA-----NYPKPIVTENRAMENYFLAEEYHQDYLK 145
gi 731458     94 DFFFRIHDPTTSNSQGPDKGTQYRSGLFAHSDADLKELAKIKEEWQP-----KWGNKIATVIEPIKNFYDAEEYHQLYLD 168
gi 12230340  118 KVFWESHNPTQGMRQGNDVGTQYRSGIYTYSEAQQQAALASKQAYQQalqqaGYG-EITTEILPAPDFYYAEDYHQQYLA 196
gi 12230335   77 DVFWSIHDPTTLNRQGPDVGEQYRSVIFYHSDEQRRAAIESRRRLEEs---gRFRDRIVTAIEPAGTFYEAEEYHQQYLE 153
gi 1709688    75 ELFWQQIDPTDAGGQFADRGSSYRAAIFYHNDKQKELAEASKQRLAEs---gIFKDPIVTDILKAEPFYEAEGYHQHFYK 151
gi 485836379 113 QVFWENHDPAQGMRQGNDHGTQYRSAIYPLTPEQDAAARASLERFQAamlaaDDDRHITTEIANATPFYYAEDDHQQYLH 192
gi 1351572    71 EALFEVIDPTIRNRQGNDIGTQYRTGIYWTDSSDEKIINDKFLKLQK-----NYSKPIVTENKKVENYYLAEEYHQDYLK 145
3PIL_A        94 DFFFRIHDPTTSNSQGPDKGTQYRSGLFAHSDADLKELAKIKEEWQP-----KWGNKIATVIEPIKNFYDAEEYHQLYLD 168

                 ...
2GT3_A       193 KNP 195
gi 2499565   146 KNP 148
gi 731458    169 KNP 171
gi 12230340  197 KNP 199
gi 12230335  154 KNP 156
gi 1709688   152 KNP 154
gi 485836379 193 KNP 195
gi 1351572   146 KNP 148
3PIL_A       169 KNP 171
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