Conserved Protein Domain Family
unchar_dom_2

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TIGR00451: unchar_dom_2 
uncharacterized domain 2
This uncharacterized domain is found a number of enzymes and uncharacterized proteins, often at the C-terminus. It is found in some but not all members of a family of related tRNA-guanine transglycosylases (tgt), which exchange a guanine base for some modified base without breaking the phosphodiester backbone of the tRNA. It is also found in rRNA pseudouridine synthase, another enzyme of RNA base modification not otherwise homologous to tgt. It is found, again at the C-terminus, in two putative glutamate 5-kinases. It is also found in a family of small, uncharacterized archaeal proteins consisting mostly of this domain.
Statistics
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PSSM-Id: 129543
View PSSM: TIGR00451
Aligned: 5 rows
Threshold Bit Score: 134.098
Threshold Setting Gi: 2495775
Created: 7-Oct-2014
Updated: 23-Jan-2015
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1877417    61 YSVDGEVLFFQKFD------ELIPSLKLVHKFPEA---YPTVQVDRGAIKFVLS-GANIMCPGLTSAGADLPpapgyeKG 130
gi 2495775    93 IIVDGEVKYLIYFDedkekwKVKLKLNGAKDLMEKgayKKIIKIKNDVVEFLKNrKGSVLRPGIVEFTDDIE------EK 166
gi 499178748  47 ILVNGEPLLMFIDD------RVVPTLRGALKMEID---RGYVVVDMGAVRFLAN-GADVMSPGIVDADPEIS------EN 110
gi 499181362  41 ILVDNEPLVINYDG------RYYLSVYGAIKLKPE---KYRVTVDEGALKFVMN-GADVMKPGIVYADERIK------EG 104
gi 499173363  49 ILVDKEPIAFKKDD------KVIPTLKLLLKSLPD---KNLVVVDIGAIKFLIN-GADVMAPGIVDADENIK------EE 112
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 1877417   131 TIVVINAENkENALAIGELMMGTEEIKSVNKGHSIELIHHLGD 173
gi 2495775   167 DDVIIVDEN-DRVVGVGLAVVSSEDIKNMEKGKVVKVRFFIKD 208
gi 499178748 111 DTVVVVDERnRRPLAVGISLISGPEMVERDSGKAVKTIHHIGD 153
gi 499181362 105 DFVFVTVEGkDSPIAVGVALCNGEEMVR-GKGKAVKNIHHIKD 146
gi 499173363 113 DVVFVVDENhKKPICVGIALMNGKEMKEADKGKAIKNLHYVGD 155
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