1UAX,1I39,1EKE


Conserved Protein Domain Family
TIGR00729

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TIGR00729: TIGR00729 
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ribonuclease H, mammalian HI/archaeal HII subfamily
This enzyme cleaves RNA from DNA-RNA hybrids. Archaeal members of this subfamily of RNase H are designated RNase HII and one has been shown to be active as a monomer. A member from Homo sapiens was characterized as RNase HI, large subunit. [DNA metabolism, DNA replication, recombination, and repair]
Statistics
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PSSM-Id: 129812
View PSSM: TIGR00729
Aligned: 9 rows
Threshold Bit Score: 267.024
Threshold Setting Gi: 10835820
Created: 7-Oct-2014
Updated: 23-Jan-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1UAX_A         3 VAGVDEAGRGPVIGPLVI-GVAVIDEkn-iERLRDIGVKDSKQLTPGQREKLFSKLId-----ILDDYYVLLVTPKEID- 74
gi 7388077     2 KAGIDEAGKGCVIGPLVVaGVACSDE----DRLRKLGVKDSKKLSQGRREELAEEIR------KICRTEVLKVSPENLD- 70
gi 7227913     3 VLGIDEAGRGPVIGPLVVaGVMIPERk--fSILRKMGVKDSKKLTPERRRFLARKIR------RIARVFTVKISASDIDr 74
gi 7227917     3 VAGVDEAGRGPVIGPLVIg-VAVIDEkn-iERLRDIGVKDSKQLTPGQREKLFSKLId-----ILDDYYVLLVTPKEID- 74
gi 2495822     3 IIGIDEAGRGPVLGPMVVc-AFAIEKer-eEELKKLGVKDSKELTKNKRAYLKKLLEn------LGYVEKRILEAEEINq 74
gi 150421651   4 VVGVDEAGRGSLVGDLVVa-GFAVEEar-lGELQSLGVRDSKQLSPAARVELYREISg------VGFFTVEAIRPWEIDg 75
gi 1730743    35 IMGIDEAGRGPVLGPMVYaVAYSTQKyqdeTIIPNYEFDDSKKLTDPIRRMLFSKIYqdneelTQIGYATTCITPLDISr 114
1I39_A        22 KAGIDEAGKGCVIGPLVVaGVACSDE----DRLRKLGVKDSKKLSQGRREELAEEIR------KICRTEVLKVSPENLD- 90
1EKE_A         3 IIGIDEAGRGPVLGPXVVc-AFAIEKer-eEELKKLGVKDSKELTKNKRAYLKKLLEn------LGYVEKRILEAEEINq 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1UAX_A        75 -----E-R--HHSMNELEAEKFVVALNSLRIKP------QKIYVDSADVDPKrf------aSLIKA-GLKyeATVIAEHK 133
gi 7388077    71 -----E-R--MAAKTINEILKECYAEIILRLKP------EIAYVDSPDVIPErl------sRELEE-ITG--LRVVAEHK 127
gi 7227913    75 -----M-R--ERGFNLNEIEKIAIKRIIPEAQP------DRVIIDSVDVKPErl------eEEIRS-HFGe-IEVTAEHG 132
gi 7227917    75 -----E-R--HHSMNELEAEKFVVALNSLRIKP------QKIYVDSADVDPKrf------aSLIKA-GLKyeATVIAEHK 133
gi 2495822    75 -----L-Mn-SINLNDIEINAFSKVAKNLIEKLnirddeIEIYIDACSTNTKkfedsfkdkIEDIIkERNlnIKIIAEHK 147
gi 150421651  76 -----E-Ni-NILVTKAVEEIVSRIVSYLGVHP------SLVVVDKYGDVQGl--------RLALTrLGIepRSILVEEK 134
gi 1730743   115 gmskfP-PtrNYNLNEQAHDVTMALIDGVIKQNvk---lSHVYVDTVGPPAS---------YQKKLeQRFpgVKFTVAKK 181
1I39_A        91 -----E-R--MAAKTINEILKECYAEIILRLKP------EIAYVDSPDVIPErl------sRELEE---ItgLRVVAEHK 147
1EKE_A        75 -----LxN--SINLNDIEINAFSKVAKNLIEKLnirddeIEIYIDACSTNTKkfedsfkdkIEDIIkERNlnIKIIAEHK 147
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1UAX_A       134 ADAKYEIVSAASIIAKVTRDREIEKLKQK---YGEFGSGYPSDPRTKEWLEEYYKQy-GDFPPIVRRTWETARKIEE 206
gi 7388077   128 ADEKYPLVAAASIIAKVEREREIERLKEK---FGDFGSGYASDPRTREVLKEWIAS--GRIPSCVRMRWKTVSNLRQ 199
gi 7227913   133 ADTRYYPVAAASIIAKVERDLEIESIQKKnrkLGDIGSGYPSDPRTREFLESFTYD---ELPDFVRRSWATVQKKKQ 206
gi 7227917   134 ADAKYEIVSAASIIAKVTRDREIEKLKQK---YGEFGSGYPSDPRTKEWLEEYYKQy-GDFPPIVRRTWETARKIEE 206
gi 2495822   148 ADAKYPVVSAASIIAKAERDEIIDYYKKI---YGDIGSGYPSDPKTIKFLEDYFKKh-KKLPDIARTHWKTCKRILD 220
gi 150421651 135 ADSRYPVVSAASIVAKVVRDARLQVLRRM---YGVRGSGYPSDPETREWVREVFAR--GEAPRVIRYTWSTVRKLGG 206
gi 1730743   182 ADSLYCMVSVASVVAKVTRDILVESLKRDp--DEILGSGYPSDPKTVAWLKRNQTSlmGWPANMVRFSWQTCQTLLD 256
1I39_A       148 ADEKYPLVAAASIIAKVEREREIERLKEK---FGDFGSGYASDPRTREVLKEWIAS--GRIPSCVRMRWKTVSNLRQ 219
1EKE_A       148 ADAKYPVVSAASIIAKAERDEIIDYYKKI---YGDIGSGYPSDPKTIKFLEDYFKKh-KKLPDIARTHWKTCKRILD 220
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