1PDO


Conserved Protein Domain Family
EIIA-man

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TIGR00824: EIIA-man 
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PTS system, mannose/fructose/sorbose family, IIA component
Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Man family is unique in several respects among PTS permease families It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars. The mannose permease of E. coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine, N-acetylglucosamine, and other sugars. Other members of this can transport sorbose, fructose and N-acetylglucosamine. This family is specific for the IIA components. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]
Statistics
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PSSM-Id: 129904
View PSSM: TIGR00824
Aligned: 5 rows
Threshold Bit Score: 174.958
Threshold Setting Gi: 548631
Created: 7-Oct-2014
Updated: 11-Oct-2014
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1PDO_A         1 TIAIVIGTHGWAAEQLLKTAEMLLGEQENVGWIDFVPGENAETLIEKYNAQLAKLDTTKGVLFLVDTWGGSPFNAASRIV 80
gi 1439527     1 MSKIIISGHGQYSIGLLNAFHMIFGENNGYCAVPFLKGEGIPQLQAKIATAVDDFKTEEPILIMVDIFGGTPYNAATQWI 80
gi 548631      1 MVHAIFCAHGQLAGAMLDSVCMVYGEVN-VSAVAFVPGENAADIAINLEKLVS-AHTDEEWVIAVDLQCGSPWNAAAGLA 78
gi 485676698   2 TIAIVIGTHGWAAEQLLKTAEMLLGEQENVGWIDFVPGENAETLIEKYNAQLAKLDTTKGVLFLVDTWGGSPFNAASRIV 81
gi 126218      1 MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTLQEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFI 80
                         90       100       110
                 ....*....|....*....|....*....|....*...
1PDO_A        81 VDKEHYEVIAGVNIPMLVETLMARdDD-PSFDELVALA 117
gi 1439527    81 YDKPEMDVISGTNLPLLLEAATDL-NE-NDIQQLVSDL 116
gi 548631     79 MRHPQIRVISGLSLPLALELVDNQ-HT-LSADDLCQHL 114
gi 485676698  82 VDKEHYEVIAGVNIPMLVETLMAR-DDdPSFDELVALA 118
gi 126218     81 AEDQRMDMAAGVNLPILLEVLSLR-EH-LALKDLLNNL 116
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