2HZP


Conserved Protein Domain Family
kynureninase

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TIGR01814: kynureninase 
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kynureninase
This model describes kynureninase, a pyridoxal-phosphate enzyme. Kynurinine is a Trp breakdown product and a precursor for NAD. In Chlamydia psittaci, an obligate intracellular pathogen, kynureninase makes anthranilate, a Trp precursor, from kynurenine. This counters the tryptophan hydrolysis that occurs in the host cell in response to the pathogen. [Energy metabolism, Amino acids and amines]
Statistics
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PSSM-Id: 130873
View PSSM: TIGR01814
Aligned: 8 rows
Threshold Bit Score: 552.032
Threshold Setting Gi: 17545478
Created: 8-Oct-2014
Updated: 11-Oct-2014
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HZP_A        66 ALHLDEEDKLRHFREXFYIPKIQ------------DlppvdlslvnkdENAIYFLG-NSLG-LQ-PKMVKTYLEEELDKW 130
gi 3913982    30 ALHLDEEDKLRHFRECFYIPKIQdlppvdlslvnkD------------ENAIYFLG-NSLG-LQ-PKMVKTYLEEELDKW 94
gi 17550466   43 AEFLSDSDALKEIRDLFHYPKAGtlpdad-pslvdP------------ESDSIYLCgNSLG-LM-PKATGEVMKDHLDKW 107
gi 499347198  10 aaaldaadplRALRDAFVFPQHG------------G------------QDQTYFVG-NSLG-LQ-PRQARAMVSEVLDQW 62
gi 6323261     4 ALELD-GEYPESLRDEFNIPTFKsmg------lssD------------DKPVTYLCgNSLG-LM-PKSTRNSINAELDAW 62
gi 499377586  10 AQEMDEQDELKQFRSEFHLK-----------------------------NESIYMDgNSLG-LM-SKRAENALHNIIDSW 58
gi 499309938   8 CLERDAADPIAPLRDAFALP-----------------------------DGVIYLDgNSLGaRP-HAALARAQQVIADEW 57
gi 499211991  10 VEALDAADPLRAMRDRFILPEG-----------------------------VIYLDgNSLG-AAaPAVFNELQKAATQEW 59
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HZP_A       131 AKIAAYGHEV------GKRPWITGDESI-VG--L--MKdiVG-A-NEKEIALMNALTVNLHLLMLSFFKP----TPKRYK 193
gi 3913982    95 AKIAAYGHEV------GKRPWITGDESI-VG--L--MKdiVG-A-NEKEIALMNALTVNLHLLMLSFFKP----TPKRYK 157
gi 17550466  108 AKMGVFGHMS------GEVPWAHCDEYC-LE--GvgRL--VG-A-KKEEVSVCNSLTVNIHVLLTSFYKP----TETRHK 170
gi 499347198  63 GALAVEGHFT------GPTQWLTYHQLV-RD--G--LArvVG-A-QPDEVVAMNTLTVNLHLMMASFYRP----SAERAA 125
gi 6323261    63 SDCAVESHFKhpeearGKVPWVSIDLPI-LP--L--LApiVG-A-QENEVAVMNSLTANLNSLLITFYKP----TEKRFK 131
gi 499377586  59 KKYGIDGWME------GDHPWYYLSEHLgEK--M--SV--LV-GgKKDEVIATGSTTINLHQLVSTFFQP----EGKRTK 121
gi 499309938  58 GEGLIRSWN--------QAGWFELPRRLgNK--L--AP--LIgA-RADEVVITDTTSINLFKVLAAALRVqredAPERRI 122
gi 499211991  60 AQDLIRAWNT--------ASWFDMPVAL-GDqlG--RL--IG-A-VSGQTVVCDTTSINIYKVLHAALGM----RPNRSV 120
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HZP_A       194 ILLEAKAFPSDHYAIE-SQLQLHg-LNIEESMRMIKPR-EgEETLRIE--DILEVIEKE-GDSIAVILFSGVHFYTgQHF 267
gi 3913982   158 ILLEAKAFPSDHYAIE-SQLQLHg-LNIEESMRMIKPR-EgEETLRIE--DILEVIEKE-GDSIAVILFSGVHFYTgQHF 231
gi 17550466  171 ILLESKAFPSDHYAIE-SQIRLKg-RTVQDSMVCLEPR-EgEETLRTE--DILDYIEKN-GDEIAIVFFSGIQYYTgQLF 244
gi 499347198 126 ILIEAGAFPSDRHAVE-SQLRLHg-LDPDTHLIEVEPDaA-DGTLSMD--AIAATIAQH-GPRLALVLWPGIQYRTgQAF 199
gi 6323261   132 ILFEKGSFPSDYYAFY-NQCKIHgiSEPENVFIQIEPR-EgETYIRTQ--DILDTIEVN-QDELALVCLSGVQYYTgQYF 206
gi 499377586 122 ILADALTFPSDIYALK-AQLQLK--GYDESHLVQVQSE-D-G---NLL--NEEHLIEAM-TDDIALIVLPSVLYRSgQIL 190
gi 499309938 123 IVSEAHNFPTDLYIAEgLADLL---------------R-D-GYKLRLI--DAPDALETAlGDDVAVTMLTHVNYKSgHMY 183
gi 499211991 121 IVAEGDSFPTDLYMAEgVASTRP--GTV----------------LRLEgvDAPTIEELI-DERVAVILVNHVNYKTgQLR 181
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HZP_A       268 NIPAIT-KAGQAKGCYVGFDLAHAV-GnVELYLHDWGVDFACWCSYKY--LNagAGG--I--AGAFIHEKH-----AHTI 334
gi 3913982   232 NIPAIT-KAGQAKGCYVGFDLAHAV-GnVELYLHDWGVDFACWCSYKY--LN--AGAg-Gi-AGAFIHEKH-----AHTI 298
gi 17550466  245 DMRAIT-EAGHRKGCFVGFDLAHAF-AnVPLHLHWWDVDFACWCSYKYgcTG--AGS--I--GGLFVHERF-----LNDQ 311
gi 499347198 200 ALGEIA-RLARAQGAAVGFDLAHAV-GnIPLSLHDDGVDFAVWCHYKY--LN--AGP--GavGGCFVHARH-----AHSN 266
gi 6323261   207 DIGRITsFAHQFPDILVGWDLAHAV-GnVPLQLHDWGVDFACWCSYKY--LN--AGPggI--GGLFVHSKHtkpdpAKES 279
gi 499377586 191 DMERLT-REAHKRNIKIGFDLCHSI-GsIPHDLHKWGVDFAFWCTYKH--LN--GGP--GsvAGLFLHEKH-----F-GV 256
gi 499309938 184 DMAAVS-ALAHRHGALAVWDLAHSAgA-VPVDLHTGGADYAIGCTYKY--LN--GGP--G--SPAFVWASP-----ALRE 248
gi 499211991 182 DMAALT-CKAHQVGALIVWDLCHTAgA-LPVELDAANADFAIGCTYKY--LN--GGP--G--APAFIYAAK-----RHHE 246
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HZP_A       335 KPALV--GWFGHELSTRFKMDNKLQ--LIPgvC--GFRIS-NPPILLVCSLHaS-LEIFKQAT-MKALRKKSVLLTGYLE 405
gi 3913982   299 KPALV--GWFGHELSTRFKMDNKLQ--LIPgvC--GFRIS-NPPILLVCSLH-AsLEIFKQAT-MKALRKKSVLLTGYLE 369
gi 17550466  312 RERML--GWWSHKMSSRFVMDNVLD--LDEgaA--GYRIS-NPPIHTVAAMLgS-LKVFDQVS-LENLRSRSCYLTGYLE 382
gi 499347198 267 LPRMA--GWWGHEQPTRFRMEPQFV--PSPgaE--GWQLS-NPPVLALAPLRaS-LELFDQAG-MPALRAKSEQLTGHLE 337
gi 6323261   280 LPRLA--GWWGNDPAKRFQMLEVFE--PIP--GalGFRQS-NPSVIDTVALRsS-LELFAKFNgINEVRKRSLLLTNYMT 351
gi 499377586 257 APGLA--GWFSSAKDKQFDMEHTLT--HAN--NagAFQIG-TPHLFSVAPLIgS-LDLFHEAG-IEKVRKKSLALTDYLM 327
gi 499309938 249 RFWQPlsGWWGHARPFAMASHYDAG---AG--I--GRFLCgTQPITSMAMVE-CgLDIFAQTS-MTALRAKSLALTDLFI 319
gi 499211991 247 DVHQPlsGWWGHARPFAFEQSYTAGsgIRR-------FLCgTQPVLSMRALKgA-LDIWDDVD-MAAVRKKSIGLTDLFI 317
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HZP_A       406 YLIKHNYGK---------DkaatkkPVVNIITPSHVEERg-CQLTITFS----VPNKD--VFQELEKRGVVCDKRNPNGI 469
gi 3913982   370 YLIKHNYGKdka---atkK------PVVNIITPSHVEERg-CQLTITFS----VPNKD--VFQELEKRGVVCDKRNPNGI 433
gi 17550466  383 YLVKTLFGEnseq--rttK------LSISIITPEEFHQRg-CQLSLKFS----SPIDI--IYPELVKRGCAVDKRYPNVI 447
gi 499347198 338 QLIHTRV-----------P------QVLQIVTPADPAQRg-CQLSLRVAgg-rTQGRA--LFEYLQSVGVLGDWREPDVI 396
gi 6323261   352 ELLEASKYYkhplrieklP------CFFTILTPTSTDEEhgAQLSLYFDsdtgKEDIMpkVFQYLHDHGVIGDARRPNVI 425
gi 499377586 328 ELIKHELDG---------H------GVV-ICNPENHIQRg-GHVYVEHP-----EAAR--ICKALKMKKVIPDFRTPSGI 383
gi 499309938 320 ELVEARCAG---------Y------P-LTLATPRDHAVRg-SHVSYAHP-----DGFA--VMQALIARGVIGDYREPSIM 375
gi 499211991 318 QLVEARCG----------A------YGLELEGPRDGNARg-SQVSFLHP-----HGYQ--VMRALIERGVIGDFRAPSTI 373
                        490       500
                 ....*....|....*....|....*.
2HZP_A       470 RVAPVPLYNSFHDVYKFTNLLTSILD 495
gi 3913982   434 RVAPVPLYNSFHDVYKFTNLLTSILD 459
gi 17550466  448 RVAPVHLYNNYVDIRRFISVLQEVAH 473
gi 499347198 397 RIAPVPLYNRFCDLHQLVEHVETWAA 422
gi 6323261   426 RLAPAPLYNTFSDVYIAVNALNEAMD 451
gi 499377586 384 RLAPVALYNTFEDVYDCVQIFKTIME 409
gi 499309938 376 RFGFTPLYTRFVDVWDAVDVLREVLE 401
gi 499211991 374 RFGFTPLYVGYKDVWQAVEVLEDILR 399
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