3C4U


Conserved Protein Domain Family
fruc_bis_ald_

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TIGR01859: fruc_bis_ald_ 
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fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist
This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]
Statistics
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PSSM-Id: 130918
View PSSM: TIGR01859
Aligned: 11 rows
Threshold Bit Score: 424.467
Threshold Setting Gi: 5902756
Created: 8-Oct-2014
Updated: 23-Jan-2015
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3C4U_A         2 LVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMG-------IDMAVGMVKIMCERYPH 74
gi 2492813     2 LVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQTSEGAIKYMG-------IDMAVGMVKTMCERYPH 74
gi 543796      3 LVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSPVILGVSEGAGRYMGg------FKTVVAMVKALMEEYKV 76
gi 1168409     3 FVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSPVIAAASDRLVDYLGg------FKTIAAMVGALIEDMAI 76
gi 1351914     2 LVNFKLMLQKAKLGKYAIPHININNYEWAKAVLTAANQANSPIIVSVSEGALKYMSg------YSVVIPLVKGLIESLSV 75
gi 13959288    4 LVNAKKMIQNAYENHYAVAAININNLEWIKAALLAAQETNSPLLLATSEGAVKYMGg------YDNCYAMVVNLIKQMNI 77
gi 3913009     3 IVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGg------YKVARNLIANLVESMGI 76
gi 499334151   2 LVTGIEILEKAHKEGYAVGAFNTSNLEITQAIVEAAEETRSPVIIQVSEGGLKYAG-------IEAISAIVRTLAEKAt- 73
gi 5902756     9 LVNTKDLFAKAVKGGYAIPAYNFNNLEQLQAIIQACVETRSPVILQVSSGARKYANat---llRNMARGAVEYAHELGVD 85
gi 499163242   6 vkNTKEILEKASKERYAIGAFNFNNMEFLQAILEAAEEEKAPVIVATSEGAIKYIGkgdietgAKLAVEMVRTYAEKLS- 84
gi 499190688   2 LVTGKDILVPARAGKYAVGAFNTNNMEITQAIIHTAEKLRSPVIVQMSEGAIKYGG--------QDLANIVIDLATRAt- 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3C4U_A        75 -IPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAG--VSVEAELGRLMGIEDNisVDEKD 151
gi 2492813    75 -IPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAG--VSVEAELGRLMGIEDNisVDEKD 151
gi 543796     77 tVPVAIHLDHGSSFESCAKAIHAGFTSVMIDASHHPFEENVATTAKVVELAHFHG--VSVEAELGTVGGQEDD--VIAEG 152
gi 1168409    77 tVPVVLHLDHGSSAERCRQAIDAGFSSVMIDGSHQPIDENIAMTKEVTDYAAKHG--VSVEAEVGTVGGMEDG--LVG-G 151
gi 1351914    76 kVPVTLHLDHG-SYDACIQALQAGFSSVMFDGSHLPFEENFNKSKKLIEIAQKTN--ASVELEVGTIGGEEDG--VIG-Q 149
gi 13959288   78 kTPVCLHLDHG-TYEGCIKAINAGYSSIMYDGSKLSIEENIKNTKELLTITKLKG--VSVEVEVGSIGGTEDG--ITS-E 151
gi 3913009    77 tVPVAIHLDHG-HYEDALECIEVGYTSIMFDGSHLPVEENLKLAKEVVEKAHAKG--ISVEAEVGTIGGEEDG--IIG-K 150
gi 499334151  74 -VPIALHLDHGTDFNTIMKCLRNGWTSVMIDASKFPLEENIQRTRKIVEIAHSMG--VSVEAEIGKIGGTEDHitVDERE 150
gi 5902756    86 -IPIVLHLDHGDSLELCIDCIESGFSSVMIDGSALPYDENVALSRKVCEYAHARAdyVTVEGELGVLAGVEDD--VVAEK 162
gi 499163242  85 -VPVALHLDHGRDFKVIMAAIKAGYSSVMIDASHLPFEENLRETKRIVEIAHAVG--ISVEAELGKLKGIEDN--VVEKE 159
gi 499190688  73 -VPVALHLDHGSSYESALNAIKMGFTSVMIDASHHPFEENVHETKRVVEAAHAMG--ISVEAELGRLGGIEEHvvVDEKD 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3C4U_A       152 AVLVNPKEAEQFVKESQVDYLAPAIGTSHGafKF--KGE------------PKLDFERLQEVKRLTN-IPLVLHGASaip 216
gi 2492813   152 AVLVNPKEAEQFVKESQVDYLAPAIGTSHGafKF--KGE------------PKLDFERLQEVKRLTN-IPLVLHGASaip 216
gi 543796    153 VIYADPKECQELVERTGIDCLAPALGSVHG--PY--KGE------------PNLGFKEMEEIGKSTG-LPLVLHGGT--- 212
gi 1168409   152 VRYADITECERIVKETNIDALAAALGSVHG--KY--QGE------------PNLGFKEMEAISRMTD-IPLVLHGAS--- 211
gi 1351914   150 GELANVDECKQIAS-LKPDALAAGIGNIHG--IY--PKNw-----------KGLNFPLIETISKITN-LPLVLHGGS--- 209
gi 13959288  152 GELANIDDCYQMCL-LDIDMLACGIGNIHG--IY--PKNw-----------KGLNFNLLKEINNKVN-KPIVLHGGS--- 211
gi 3913009   151 GELAPIEDAKAMVE-TGIDFLAAGIGNIHG--PY--PVNw-----------EGLDLDHLQKLTEALPgFPIVLHGGS--- 211
gi 499334151 151 ASMTDPEEALRFAKETGVDYLAIAIGTAHG--PY--KGE------------PKLDFERLKRIKELLN-MPLVLHGAS--- 210
gi 5902756   163 SHYTMPDEVEDFVKKTGVDSLAISIGTSHGraKF--TPEqctrnadgvlipPPLRFDILAEIEKRIPgFPIVLHGASsvp 240
gi 499163242 160 SVLVDPEEAKVFVKETEVDFLAPAIGTSHGafKF--KGE------------AQLDFERLKKVKEYTQ-IPLVLHGASmvp 224
gi 499190688 150 AFLTDPDEAVKFVEETGTDYLAIAIGTSHG--AYkgKGR------------PFIDQARIKKIGELLS-IPLVAHGSS--- 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3C4U_A       217 dnvrksyldaggdlkgskGVP---------------------FEFLQESVKGGINKVNTDTDLRIAFIAEVRKVAN---- 271
gi 2492813   217 dnvrksyldaggdlkgskGVP---------------------FEFLQESVKGGINKVNTDTDLRIAFIAEVRKVAN---- 271
gi 543796    213 ------------------GIP---------------------TADIKKSISLGTAKINVNTENQISSAKAVRETLA---- 249
gi 1168409   212 ------------------GIP---------------------QDQIKKAITLGHAKININTECMVAWTDETRRMFQ---- 248
gi 1351914   210 ------------------GIL---------------------ENDVKKAISLGICKLNINTECQLAFAHEIRKYIEsnkd 250
gi 13959288  212 ------------------GIS---------------------DEQILKAINLGVAKININTECQIAFSNALQDHLTkagd 252
gi 3913009   212 ------------------GIP---------------------DEQIQAAIKLGVAKVNVNTECQIAFANATRKFARdyea 252
gi 499334151 211 ------------------GVP---------------------EEAIKKAVSLGINKINIDTDVRQAFTARLRRLLE---- 247
gi 5902756   241 veyvreveryggnlpdsvGIP---------------------EEQLRKAAKSAVCKVNIDSDGRLAMTAAIRRVLT---- 295
gi 499163242 225 qdivklaneygaelsgakGVP---------------------EDMLKKAIELGINKINTDTDLRITFVAYLRKVLS---- 279
gi 499190688 212 ------------------GVPaeivqrlraaggeigdaagiaDEDLTEAAQYGIAKVNVDTDLRLASTVGIREVLK---- 269
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
3C4U_A       272 -----EDKSQFDLRKFFSPAQLALKNVVKERMK-LLGSANKI 307
gi 2492813   272 -----EDKSQFDLRKFFSPAQLALKNVVKERMK-LLGSANKI 307
gi 543796    250 -----AKPDEYDPRKYLGPAREAIKETVIGKMR-EFGSSNQA 285
gi 1168409   249 -----ENSDLYEPRGYLTPGIEAVEETVRSKMR-EFGSAGKA 284
gi 1351914   251 --ldlNKKG-YDPRKLLKEPTQAIVDTCLEKID-LCGSRNKA 288
gi 13959288  253 --lilSKQ--YDPRKILAYGVDAIKNTIIDKFT-KFNSLNKI 289
gi 3913009   253 neaeyDKKKLFDPRKFLADGVKAIQASVEERID-VFGSEGKA 293
gi 499334151 248 -----EDKEVYDPRKILGPCKEAMKEVIKQKMI-LFGSSLKA 283
gi 5902756   296 -----TKVDEFDPRKYLGPARDELKKLYMHKNKeVLGSAGRA 332
gi 499163242 280 -----EDKSQIDPRKIFKPVFEQVKEIVKERIR-IFGSSGKA 315
gi 499190688 270 -----ATPKEFDPRKIFGPARDVMSQIVEHKMG-VLGSVGKA 305
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