3EF0


Conserved Protein Domain Family
FCP1_euk

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TIGR02250: FCP1_euk 
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FCP1-like phosphatase, phosphatase domain
This model represents the phosphatase domain of the humanRNA polymerase II subunit A C-terminal domain phosphatase (FCP1) and closely related phosphatases from eukaryotes including plants, fungi, and slime mold. This domain is a member of the haloacid dehalogenase (HAD) superfamily by virtue of a conserved set of three catalytic motifs and a conserved fold as predicted by PSIPRED. The third motif in this family is distinctive (hhhhDDppphW). This domain is classified as a "Class III" HAD, since there is no large "cap" domain found between motifs 1 and 2 or motifs 2 and 3. This domain is related to domains found in the human NLI interacting factor-like phosphatases, and together both are detected by the pfam03031.
Statistics
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PSSM-Id: 131304
View PSSM: TIGR02250
Aligned: 18 rows
Threshold Bit Score: 212.139
Threshold Setting Gi: 22212705
Created: 8-Oct-2014
Updated: 11-Oct-2014
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3EF0_A        13 LRQEKRLSLIVDLDQTIIHATVDPTVGEWMS----DPGNVNYDV---LRDVRSFNLqegpsgY--------TSCYYIKFR 77
gi 57863785  165 LLRERKLVLILDLDHTLINSTKLFDLSAAENe--lGIQSAAKEV---VPDRSLFTL------E--------TMQMLTKLR 225
gi 47497233  101 LLRARKLILVVDLDHTLINSTRFAHLSDDEKa--nGFTERTGDD----RSRGLFRM------G--------LFRMITKLR 160
gi 22212705  922 MFASQKLSLVLDIDHTLLNSAKFNEVESRHEeilrKKEEQDREKp--YRHLFRFLH------Mg----------MWTKLR 983
gi 9759494    83 CFNDKKLHLVLDLDHTLLHTVMISNLTKEETy---LIEEEDS-----REDLRRLNG------Gys-------sEFLIKLR 141
gi 9294260    71 VYGRKKLHLVLDLDHTLIHSMKTSNLSKAEKy---LIKEEKSGS---RKDLRKYNN------------------RLVKFR 126
gi 9759085    81 WLEDKKLHLVLDLDQTLIHTIKTSLLYESEKy---IIEEVES-----RKDIKRFNT------Gfp-------eESLIKLR 139
gi 21914376  155 LLGAKKLTLIVDLDQTVIHTTCERTIAEWQA----DPENPNHGA---VKDVEGFQL------AddnvsnvaANWYYVKKR 221
gi 19069153   55 LEMQMKLILVLDLDQTVLHTTYGTSSLEG---------------------TVKFVI------Dr--------CRYCVKLR 99
gi 9758369   742 LQRQRKLYLVLDLDHTLLNTTILRDLKPEEEy--lKSHTHSLQDgcnVSGGSLFLL------E--------FMQMMTKLR 805
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3EF0_A        78 PGLAQFLQKISELYELHIYTMGTKAYAKEVAKIIDPTGKLFQDRVLSRDDSG------SLAQKS--LRRLFPc----DTS 145
gi 57863785  226 PFVRRFLKEASDMFEMYIYTMGDKAYAIEIAKLLDPDNVYFGSKVISNSDCT------QRHQKG--LDVVLG-----DES 292
gi 47497233  161 PFVHEFLREASAMFEMHVYTLGNRNYATAVAKLLDPDGAYFGERIISSGESS------QPDRKS--LGDVFGwapemERA 232
gi 22212705  984 PGIWNFLEKASKLYELHLYTMGNKLYVTEMAKLLDPKGVLFNGRVISKGDDGdpldgdERVPKSkdLEGVMG-----MES 1058
gi 9759494   142 PFVHEFLKEANKMFSMYVYTMGDRDYAMNVLNLIDPEKVYFGDRVITRNE--------SPYIKT---LDLVLa----DEC 206
gi 9294260   127 PFVEEFLKEANKLFTMTAYTKGGSTYGQAVVRMIDPNKIYFGDRIITRKE--------SPDLKT---LDLVLa----DER 191
gi 9759085   140 PFVHQFLKECNEMFSMYVYTKGGYDYARLVLEMIDPDKFYFGNRVITRRE--------SPGFKT---LDLVLa----DER 204
gi 21914376  222 PGLEDFFKRMSKLYEMHVYTMATRAYAQAVCKIIDPDRRYFGDRILSRDENY------TDKTKS--LSRLFq-----NTT 288
gi 19069153  100 PNLDYMLRRISKLYEIHVYTMGTRAYAERIVEIIDPSGKYFDDRIITRDENQ------GVLVKR--LSRLFPh----DHR 167
gi 9758369   806 PFVHSFLKEASEMFVMYIYTMGDRNYARQMAKLLDPKGEYFGDRVISRDDGT------VRHEKS--LDVVLG-----QES 872
                        170       180
                 ....*....|....*....|....*...
3EF0_A       146 MVVVIDDRGDVWDWNP-NLIKVVPYEFF 172
gi 57863785  293 VAVILDDTEYVWQKHKeNLILMERYHYF 320
gi 47497233  233 AVVILDDTAEVWKGYRdNLIEMERYLYF 260
gi 22212705 1059 SVVIIDDSVRVWPQHKmNLIAVERYLYF 1086
gi 9759494   207 GVVIVDDTPHVWPDHKrNLLEITKYNYF 234
gi 9294260   192 GIVIVDNTPNVWPHHKrNLLEITSYFYF 219
gi 9759085   205 GIVIVDDTSSVWPHDKkNLLQIARYKYF 232
gi 21914376  289 MVVIIDDRADVWQYSP-HLVRVPVFNFF 315
gi 19069153  168 NIVILDDRPDVWDYCE-NLVLIRPFWYF 194
gi 9758369   873 AVLILDDTENAWPKHKdNLIVIERYHFF 900
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