Conserved Protein Domain Family
OrgA_MxiK

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TIGR02555: OrgA_MxiK 
type III secretion apparatus protein OrgA/MxiK
This gene is found in type III secretion operons and has been shown to be essential for the invasion phenotype in Salmonella and a component of the secretion apparatus. The protein is known as OrgA in Salmonella due to its oxygen-dependent expression pattern in which low-oxygen levels up-regulate the gene. In Shigella the ghene is called MxiK and has been shown to be sessential for the proper assembly of the secretion needle complex.
Statistics
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PSSM-Id: 131606
View PSSM: TIGR02555
Aligned: 6 rows
Threshold Bit Score: 192.697
Threshold Setting Gi: 45504741
Created: 8-Oct-2014
Updated: 23-Jan-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52422281    6 LMRVMYGPLGYAHPDHRTIAGVDLArMPAD-VANQWLIDHHRLDtAIDFDWRDAPrAAPCVDHWARLPRIAYLIGVQRLR 84
gi 45504783    6 LDSVMFDPLTWIHPSRFALPASLDG-IAQRsIVNDMLISLYGLS-LERPALPTHSlPRQFVEAWHLLPQIALLMACQRHR 83
gi 27735217   11 YLSIIFDPAFYINRNRLNLPSELLEnGVIRsEINNLIINKYDLNcDIEP-LSGV--TAMFVANWNLLPAVAYFIGSQESR 87
gi 45504741    9 vMRVMYHPVSYLHASRFP-SGWHREdQAAHpLLNHWILRHYHCP-SDDGADRGDPfYRFLLDNWQRLGDAALLIGAHLLR 86
gi 485662088   5 LRKIIYAPISYIHPQRVSLNNTPINnPVLRsITNEMILLQYNLS-VEHFNLNSSL--IYYINNWNLLPLICLLSGCHFYR 81
gi 447004340  10 WQRIIFDPLSYIHPQRLQIAPEMIVrPAARaAANELILATWRLKnGEKECIQNSL-TQLWLRQWRRLPQVAYLLGCHKLR 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52422281   85 AALVERGRYVRLDASSQRFL----------CMPLAAVPKAA-CAGMPDDDAIVAAGTACLTAALHDAPRALRQRLPLLF- 152
gi 45504783   84 ASLAKGGYGASLPDWLRQFA----------ALSLVSSRSSP-GETIPPPAQLLAWGKYELLAFAGSLPRGLRQRLDLLF- 151
gi 27735217   88 --------LINHSEMVISYY----------GGKISKQGEAA-----------IRSGFWHLIAWKENISVGIYERINLLFn 138
gi 45504741   87 NRLLSEGRFILLSAPVQSFLalplppltpgALPQEQEEPATtLLQDPDPAA---WGAYCLLSMLKRLSPAVYRRACLLF- 162
gi 485662088  82 ERFAERGFFYKVPDVLRDYLs---------AIPLEINEKARyKPGIANYHNIITCGFSTLLPYIRQQPLAMQQRFNLLF- 151
gi 447004340  89 ADLARQGALLGLPDWAQAFL----------AMHQGTSLSV--CNKAPNHRFLLSVGYAQLNALNEFLPESLAQRFPLLF- 155
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 52422281  153 PrahaaRLASGLDGAHDDAraAWSSSLFSFAVNHALlEPAPVS 195
gi 45504783  152 PpeegrDDLSRLSLPPPCR--LLLKLAFQHAKRHPA-TPDTAD 191
gi 27735217  139 P-----IALEGNYTPVERNlsRLN-EGMQYAKRHFTgIQTSCL 175
gi 45504741  163 P----------VEQPLPQQatSLSPSSINLIKMALHhAQYFTR 195
gi 485662088 152 P-----DFVDHILSPLPLAstLLERITFYAKKNRDElDKISCK 189
gi 447004340 156 P-----PFIEEALKQDAVEmsILL-LALQYAQKYPNsVPAFAC 192
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