Conserved Protein Domain Family
PEP_exosort

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TIGR02595: PEP_exosort 
PEP-CTERM protein-sorting domain
This model describes a 25-residue domain that includes a near-invariant Pro-Glu-Pro (PEP) motif, a thirteen residue strongly hydrophobic sequence likely to span the membrane, and a five-residue strongly basic motif that often contains four Arg residues. In nearly every case, this motif is found within nine residues, and usually within five residues, of the extreme C-terminus of the protein. Proteins with this motif typically have signal sequences at the N-terminus. This region appears many times per genome or not at all, and co-occurs in genomes with a proposed protein-sorting integral membrane protein we designate exosortase (see TIGR02602). PEP-CTERM proteins frequently are poorly conserved, Ser/Thr-rich proteins and may become extensively modified proteinaceous constituents of extracellular material in bacterial biofilms. [Cell envelope, Surface structures]
Statistics
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PSSM-Id: 131644
View PSSM: TIGR02595
Aligned: 65 rows
Threshold Bit Score: 26.3826
Threshold Setting Gi: 78193917
Created: 8-Oct-2014
Updated: 23-Jan-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20
                ....*....|....*....|....*..
gi 17132952 221 IPEPSQVPGLVTLGglgLMVIGKKLKL 247
gi 17130268 239 TPEPTTVLGLGAVA---TLAFLRRRQF 262
gi 17135109 180 IPEPGVIFGLLAVG---SLARVLKKKP 203
gi 75701630 326 VPEPSGLFGLFTVG---SLIIASRSKC 349
gi 17132767 315 TPESSTTIGVLFLGvlgAMSNIKRLQR 341
gi 75702241 239 TPEPATLIGLFGLGafgITSNLKRNRK 265
gi 75704658 298 VPEPSITIGFLGLGllaFGSRLKNKNR 324
gi 75700783 165 VPEPNSILSLIALGtlgAGSVLKHNQR 191
gi 17130530 494 VPEPTTIFGLFGIAimgIATKLKRRCE 520
gi 17129768 416 VPEPTTVLGSLTAAalgASSMLKKRKR 442
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