2GA5,1EKG


Conserved Protein Domain Family
mito_frataxin

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TIGR03422: mito_frataxin 
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frataxin
Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.
Statistics
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PSSM-Id: 132463
View PSSM: TIGR03422
Aligned: 27 rows
Threshold Bit Score: 139.678
Threshold Setting Gi: 71652204
Created: 9-Oct-2014
Updated: 23-Jan-2015
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2GA5_A        21 KYHEEADDYLDHLLDSLEELSEAHPDCi-pDVELSHGVMTLEI-PAFGTYVINKQPPNKQIWLASPLSGPNRFDLL---- 94
gi 37048704   56 EYEHVSERDMETLNESLEIFCEDFGNGn-wEIEYSSGVLNLTL-PPYGTYVLNKQPPNLQIWMSSPVSGPSRFEYI---- 129
gi 115698485  49 QFEKIVDEALDHLSEFFEILGDSEKCPadfDVLYSSGVLTVAFgQEHGTYVINKQTPNKQIWLSSPTSGPKRYDYI---- 124
gi 9910697    72 TYERVCSDTLDALCDYFEELTENASELqgtDVAYSDGVLTVNLgGQHGTYVINRQTPNKQIWLSSPTSGPKRYDFV---- 147
gi 62510646   94 TYERLAEETLDSLAEFFEDLADKPYTFedyDVSFGSGVLTVKLgGDLGTYVINKQTPNKQIWLSSPSSGPKRYDRT---- 169
gi 9910696    24 EYETAADSTLERLSDYFDQIADSFPVSeqfDVSHAMGVLTVNVsKSVGTYVINKQSPNKQIWLSSPMSGPKRYDLE---- 99
gi 53791696   91 EYHKLADETIHDLLEKLEEYGDSL-QMdgfDIDYGNQVLTLRL-GELGTYVVNKQAPNRQIWLSSPVSGPSRFDWDap-- 166
gi 83302740   80 EFHKLANFTINHLLEKIEDYGDNV-QIdgfDIDYGNEVLTLKL-GSLGTYVLNKQTPNRQIWMSSPVSGPSRFDWDrd-- 155
gi 66536649   92 QFEKVSDETLTSLTEYFDELVEQAIHLsdaDVSYGDGVLTIKFgDTHGTYVINRQSPNRQIWLSSPKSGPKRYDFI---- 167
gi 72386543   65 AYNTAADTFLERVESALETIGDTDTLE---DVNLAGGVLVIET-TSRGTFVLNKQAPNVQLWLSSPLSGPHHYDMTtsat 140
                         90       100
                 ....*....|....*....|....*....
2GA5_A        95 -N----GEWVSLR-NGTKLTDILTEEVEK 117
gi 37048704  130 -N----GSWVHHRkEGVKLGELLSGELKE 153
gi 115698485 125 -N----KRWIYVH-DGMAIHDLLSEEISK 147
gi 9910697   148 -GtvaaGRWIYKH-SGQSLHELLQQEIPG 174
gi 62510646  170 -G----KNWVYSH-DGVSLHELLGAELTK 192
gi 9910696   100 -Ee---GKWTYAH-DGEQLDSLLNREFRK 123
gi 53791696  167 -----tNCWIYRR-TGANLVELLEKEIGE 189
gi 83302740  156 -----aNAWIYRR-TEAKLHKLLEEELEN 178
gi 66536649  168 -D----GKWIYKY-DRKTLHELLDDEIPA 190
gi 72386543  141 gS----VEWRADA-DGHSLEERLEKELSD 164
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