Conserved Protein Domain Family
T1SS_rpt_143

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TIGR03660: T1SS_rpt_143 
T1SS-143 repeat domain
This model represents a domain of about 143 amino acids that may occur singly or in up to 23 tandem repeats in very large proteins in the genus Vibrio, and in related species such as Legionella pneumophila, Photobacterium profundum, Rhodopseudomonas palustris, Shewanella pealeana, and Aeromonas hydrophila. Proteins with these domains represent a subset of a broader set of proteins with a particular signal for type 1 secretion, consisting of several glycine-rich repeats modeled by pfam00353, followed by a C-terminal domain modeled by TIGR03661. Proteins with this domain tend to share several properties with the RtxA (Repeats in Toxin) protein of Vibrio cholerae, including a large size often containing tandemly repeated domains and a C-terminal signal for type 1 secretion. [Cellular processes, Pathogenesis]
Statistics
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PSSM-Id: 132699
View PSSM: TIGR03660
Aligned: 24 rows
Threshold Bit Score: 122.777
Threshold Setting Gi: 54293628
Created: 9-Oct-2014
Updated: 11-Oct-2014
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686261084 1080 GSFDSVEGADTIVSYQLD-LSG-NPISG--VTSGGQAVMLVQTGVNNNN--YTYQGqT-------PDG--K-S--VFTLV 1141
gi 646487193  748 GQFEVTS-ADGIDSFVLD-LNS-NLLPA--LTSGGESIAITQDATASTSdaLVYVGkT-------AGG--D-T--IFTLT 810
gi 686261084  931 GHFNVVAGADEIVSYHVS-DLA-GAVAG--LQSNGQDVELRLVSEADGV--STYEAvI-------VGT--NtQ--IFTLT 993
gi 686261084  780 GHFDVVDGADSIVSFQLE-DLV-LPVAG--LTSAGQPLELVEYSNANGV--IEYRA-Y-------VQG--T-TdiVFKLT 842
gi 686261084  332 GKFVATEGADHIVEYHIV-DLN-TPVQG--LTSGGQSLILVEVSNSGGV--SVYEA-I-------IDGttT-P--AFRVT 394
gi 686261084  483 GTFDVTEGADQVTSIQLS-DLT-TPVST--LMSGGEAITLVLTSSTGGV--NVYQGiT-------VNS--QeV--VFELT 545
gi 469694121  357 GQFDTQLGSDQVASYQID-PSTaNPIAG--LTSQGDAVILGEPTLIDGN--RVYQA-T-------AGG--R-D--IFQLT 418
gi 499539898 2343 GQITVDSGSDEVVDFKVDvDAF-NANNT--ITSAGNSVSLID----AGN--GLYQG-M-------ANG--N-V--VFEFQ 2400
gi 501558685  569 GDLEVHWGADDGAARHILmATD-GLPSG--LTSDGVAIDYQTTVDAAGY--AVVMA-YkhggspnAAS--D-Q--VFSLT 637
gi 493271471 7506 GQITVDSGSDEVTDFVIDvATF-NQQNAgvLMSDGQQITLSYNSN---N--GNYFG-K-------VGN--T-T--IFVIK 7566
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686261084 1142 LN-A-DGT--YKFTLEGVLDHG--Vq-G---EDLLTLNLPVFATDVDGDTA-G-I-NLPVTITDDIPTIYDSS---I--- 1202
gi 646487193  811 LH-Q-DGR--YDFELSGALDHA--T--N---SDDLTINLPIVITDGDNDSV-N-A-TLPVTILDDKPTIEAIR---Pgsh 873
gi 686261084  994 LD-AkDNS--YQFELVGPVDHP--AglG---ENSLTLDIPISVTDFDGDTSaS-V-NLPITIVDDVPEIKTAT---P--- 1057
gi 686261084  843 LN-AgEDR--YQFELFAQLDHPngN--G---ENELVIDFPVNATDFDGDVS-NtI-SLPITVVDDVPSITGVDnssQ--- 909
gi 686261084  395 LDvS-DGS--YKFELLEPLDHP--TsnG---QNDIVINLPIAATDFDGDVS-N-TlTLPITVVDDVPTIDGLA---Qgse 461
gi 686261084  546 LN-AsNNS--YEFDLRKALDHP--D--Gn-qQNNIIIELPITVTDGDGDVS-P-VfTLPITVVDDVPVVTNID---R--- 609
gi 469694121  419 LN-A-DGS--YQFVLQGTLDHA--A--G---SDALTISLPIVAIDYDNDSS-A-PgNLNIEIQDDKPIIIGAE---Q--- 479
gi 499539898 2401 LN-A-DGS--YEFEIKGPIDHS--Iq-G---KDSITIDIPVYAVDQDGDTSeN-V-DMSVDVLDDIPSVKDKN------- 2461
gi 501558685  638 FS-E-DGSgtYTFRLLGNLDHA--E--N---SNSQELVFKVDAYDSDGDPV-T-Q-TFTVDVADDQPFAIGTI---Lt-- 700
gi 493271471 7567 LS-N-SGK--YEFILKGNVDHE--E--GgltDDELIITLPIQAIDQDGDKS-N-TvNVPVTIKDDEPTATDVT---L--- 7630
                         170       180       190
                  ....*....|....*....|....*....|.
gi 686261084 1203 TRVEgqgtrtvqlfqdpvEGDLNY-GADGSE 1232
gi 646487193  874 LSID--------------EDDIPNkGSDGQG 890
gi 686261084 1058 LFLD--------------EDDLPS-GSELSK 1073
gi 686261084  910 LTID--------------EDDLPA-GSDTSG 925
gi 686261084  462 QTVD--------------EDDLPQ-GTDRAQ 477
gi 686261084  610 LQVH--------------EDDLPL-GSDETK 625
gi 469694121  480 LTVA--------------EQTLDT-GSIGGG 495
gi 499539898 2462 ITIT--------------EGDNSD-KVDVLN 2477
gi 501558685  701 RTVE--------------EEELQG-GNEDTR 716
gi 493271471 7631 NTVEgls--------ttsADVLTI-IGEGAD 7652
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