1CDZ,1IMO,1JNX,1WF6,2COE,2COK,2D8M,2EBW,2EP8,2JW5,2NTE,2R1Z,3EF0,3II6,3II6,3JVE,3KTF,3L40,3L46,3OLC,3SQD,3SQD,3SZM,3UEN,4BMD,4BMD,4BU1,4BU1,4N40,2EBU,1JNX,3K05,3K05,3COJ,2VXC,5ECG,3AL3,4Q66,2NTE,3COJ,5ECG,4N40


Conserved Protein Domain Family
BRCT
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cd00027: BRCT 
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C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.
Links
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Statistics
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PSSM-Id: 349339
Aligned: 343 rows
Threshold Bit Score: 28.0965
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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BRCT sequence
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: BRCT sequence motif, 2 residue positions
Conserved feature residue pattern:W [CS]Click to see conserved feature residue pattern help
Evidence:
  • Comment:The Trp-X-X-X-Cys/Ser is considered a signature motif of the BRCT family.
  • Comment:BRCT sequence motif is not conserved in some family members.
  • Citation:PMID 9799248
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
1CDZ_A          9 KHFFLYGefpg----------------------derRKLIRYvtafNGELEDYmsd--------rvQFVITaqewdpsfe 58   human
1723501       224 KRIYFSNdlnlp--------------------tnfrHSLQKFsvgiGAKIAESin---------dcDIFIGlkrdtief- 273  fission yeast
Q92547        556 KSFLVLGfsn-----------------------eneSNIANIikenAGKIMSLlsr-------tvaDYAVVpllgce--- 602  human
KOB79516      869 DFISFSEee--------------------------rSHLERHwvayGGYVIKSirs-------pnvDYLVHkndviefkh 915  winter moth
XP_018896229  579 LNFLCHNldsa----------------------ieaEVMEDVir-aGGKIVPPrfa-------gvlDYTVTsvltte--- 625  Bemisia tabaci
XP_011402470  401 LSFSINEviss----------------------qsrSAIENEikknGGSVVSCdrs--------cdYHIASlsvpps--- 447  Amphimedon qu...
EPZ31689      302 KVGFFSGcsfkv-------------------lcnqkINLEKSiienGGIIEETn-----------pKYFIVdldqsdees 351  Rozella allom...
CEO98011      438 THLLFSGknfslehs--------------sldsgerEEIRNDiiahGGVVIHPdnaggvrlhftvaRYIVAepgccmlfd 503  Plasmodiophor...
XP_001014964  954 LTFVCQNsfdn----------------------lnkEEVRKLvesaGGSFLYEkpk-------htsAYFLSdpskteyn- 1003 Tetrahymena t...
EMG46268      105 MSVCLSRiglstsqidhlvntvefrpknakydyftpRNLLKVfyknGGEAKETlqr--------sqDFIITadprgtry- 175  Candida malto...

Feature 1                                #   #
1CDZ_A         59 -------ealmdnpsLAFVRp-RWIYSC 78   human
1723501       274 --------nlasnknTTIGTi-SWLLNL 292  fission yeast
Q92547        603 ----------veatvGEVVTn-TWLVTC 619  human
KOB79516      916 m----qnlknklhpnVRHVNk-NWILNC 938  winter moth
XP_018896229  626 ----------lqtttCEVVTh-LWIKDC 642  Bemisia tabaci
XP_011402470  448 ----------lpssaRVIVSi-LWFDHC 464  Amphimedon queenslandica
EPZ31689      352 nslvsetfsngastsTLMVTt-LWVNRC 378  Rozella allomycis CSF55
CEO98011      504 d----ivqawddgsrPILVTp-GWLQGC 526  Plasmodiophora brassicae
XP_001014964 1004 --------kqqnesnEIVLDieGLLQTC 1023 Tetrahymena thermophila SB210
EMG46268      176 --------nkaiewnVPVVHp-IWIVDS 194  Candida maltosa Xu316

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