1JL3,1D1Q,4PIC,2WMY,2CWD


Conserved Protein Domain Family
LMWP

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cd00115: LMWP 
Click on image for an interactive view with Cn3D
Low molecular weight phosphatase family
Low molecular weight phosphatases (LMWPs) are a group of small soluble enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). This family includes protein tyrosine phosphatases, arginine phosphatases and arsenate reductases.
Statistics
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PSSM-Id: 319970
View PSSM: cd00115
Aligned: 5 rows
Threshold Bit Score: 181.534
Threshold Setting Gi: 16975124
Created: 1-Nov-2000
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:The active site sequence motif of LMWP has a conserved (V/I)CXGNXCRS sequence.
  • Structure:1D1Q; Saccharomyces cerevisiae low molecular weight protein-tyrosine phosphatase with bound 4-nitrophenylphosphate, contacts 4 A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                      10        20        30        40        50        60        70        80
              ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          # ######                                                                   
1JL3_A      5 IIYFLCtGNSCRSQMAEGWAKQYlgd------ewKVYSAGIeah----glNPNAVKAMKEVGIDIsnqTSDIIDsdilnn 74
1D1Q_A      9 SVAFIAlGNFCRSPMAEAIFKHEvekanlenrfnKIDSFGTsnyhvgespDHRTVSICKQHGVKIn-hKGKQIKtkhfde 87
4PIC_A      4 RILFVCtGNTCRSPXAAALLENKqlp------gvEVKSAGVfaae-gseaSVHAKXVLKEKGIEAa-hRSSQLKkehidw 75
2WMY_A     10 SILVICtGNICRSPIGERLLRRLlp-------skKINSAGVgalv-dhtaDESAIRVAEKNGLCLkghRGTKFTsalarq 81
2CWD_A      6 RVLFVClGNICRSPMAEGIFRKLlkerg-ledrfEVDSAGTgawhvgepmDPRARRVLEEEGAYFp-hVARRLTredvla 83
                      90       100       110       120       130       140       150
              ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
Feature 1                                                  # #                             
1JL3_A     75 ADLVVTLcgdaadkcpmt---------------pphvkrehwgFDDPARaqgteeekwaFFQRVRDEIGNRLKEFAE 136
1D1Q_A     88 YDYIIGMdesninnlkkiqpegskakvclfgdwntndgtvqtiIEDPWYgd------iqDFEYNFKQITYFSKQFLK 158
4PIC_A     76 ATHVLAXtsghkdxiverfpeak----dktftlkqfvsgtdgdIADPFGgp------ieVYRAARDELETLIDRLAE 142
2WMY_A     82 YDLLLVMeyshleqisriapea------rgktmlfghwldskeIPDPYRms------deAFDSVYQLLEQASKRWAE 146
2CWD_A     84 YDHILVMdrenleevlrrfpea------rgkvrlvleelgggeVQDPYYgd------leDFREVYWTLEAALQAFLD 148

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