Conserved Protein Domain Family
rhv_like

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cd00205: rhv_like 
Click on image for an interactive view with Cn3D
Picornavirus capsid protein domain_like. Picornaviruses are non-enveloped plus-strand ssRNA animal viruses with icosahedral capsids composed of 60 copies each of 4 virus encoded proteins; alignment includes picornaviridae, like poliovirus, hepatitis A virus, rhinovirus, foot-and-mouth disease virus and encephalomyocarditis virus; common structure is an 8-stranded beta sandwich
Statistics
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PSSM-Id: 119412
View PSSM: cd00205
Aligned: 102 rows
Threshold Bit Score: 63.9544
Threshold Setting Gi: 640402
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
drug-binding
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:drug-binding pocket [chemical binding site]
Evidence:
  • Comment:inner one-third of the pocket is lined exclusively by non-polar side chains
  • Comment:hydrophobic pocket in the core of the beta-barrel of the capsid protein
  • Citation:PMID 7820548
  • Structure:1VBB_1, R80633 antiviral agent
    View structure with Cn3D
  • Citation:PMID 9261087
  • Structure:1EAH_1, SCH48973 antiviral agent
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                       #                                 
1VBB_1         75 IESFFa--RGACVAiievdneqp---------ttraqklfAMWRITYkd------------------------------- 112
gi 157939779  323 LIDLSh--IPSMVTndttdyhyfdwt---dttnkdeiigkFNFKLNS--------------------------------- 364
gi 7674174     99 VDVFHs--MAYDITtgdknpskl--------irldtttwqHTWPRQHlindvelpk-------------------afwdk 149
gi 7674174    371 IAQLFsvmSDTTTPstssgi---------------ddlgyLDWSATYvpqqvihr--------------------nvvkl 415
gi 195364271   62 TDDFYs--CSYEVGaqgdnis------------rlvhlhtGQWSTQHgvttclrwlat---------------pgcfyta 112
gi 3002544     45 VVQAS---VAPTMPikpdfkntd--------nflsmsyspNTAPTNPtkmvhlangtwttsqhrqslvasiqlpqafwpn 113
gi 3002544    320 LMEIA---RMPSVYkgertep-------------ggtngyFQWSHTHspinwvfd--------------------ggihl 363
gi 2493476   1708 PEAIRn--CFAVFRtf-----------------------aWNDRMPTgtflgsi-----------------------slh 1739
gi 18766569   181 QQTISe-kLPSTVGdlviasseptqq---frgltnrwmpiNSIKVTVnskrndilaqyy------------ipedflsth 244
gi 62287092  1803 TSVVTaenSSASIAtagiggppqqvdqqetwrtnfyyndvFTWSVADapgsilyt---------------------vqhs 1861
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                             # # #                        #                             #
1VBB_1        113 --tVQLRRKLe-FFTYSRFDMEFTFVVTanftnann--ghalnqvYQIMYIPPgaptpksw------ddytwqtSSNPSI 181
gi 157939779  365 ---VPNSAILanSYSFFRGPIIFHVIAAastm---------hrgrLRVCFRPNsnqey-----------sapqsMAVYYS 421
gi 7674174    150 nskPAYGQSR--YFAAVRCGFHFQVQINvnqg---------tagcALVVYEPKpivthgg-------hlefgsyTNLPHV 211
gi 7674174    416 nqfSNLKPFVn-AYTYFRGSLVLRMSVYastf---------nrgrLRMGFFPNfttnt------------tsemDNAIYT 473
gi 195364271  113 ntqPAYGQTR--YFRFIRCGYHFRLLVNapsg---------aaggLMMVWMPYpycrvltgsynvdasvdrrslLNLPYA 181
gi 3002544    114 eryPAWGQSR--YFAAVRCGFHIQVQLNvnig---------sagcLIAAYMPKsahdhmd-------tytfssyTNLPHV 175
gi 3002544    364 edmPNLNLFSs-CYNYWRGSTVLKLTVYastf---------nkgrLRMAFFPNhdaryt---------eeeaqnAIFMVC 424
gi 2493476   1740 pniNPYTSHLsgMWAGWGGSFEVRLSISgsgv---------fagrIIASVIPPgvdps-----------sirdpGVLPHA 1799
gi 18766569   245 akcAPNTIPFe-TYVYGKYELEMKFVANgnkfqcgkviisvkfdsYQADNINTgfq----------------aaLSRPHI 307
gi 62287092  1862 pqnNPFTAVLsqMYAGWAGGMQFRFIVAgsgv---------fggrLVAAVIPPgieig-----------pglevRQFPHV 1921
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                               #                                #                        
1VBB_1        182 FYTYGa-aPARISVPYVGLANAYSHFydgfakvplktdandqigdslysamtvddFGVLAVrvvndhn---ptkvtskVR 257
gi 157939779  422 LLDISqsnCCTLAVPFNSETWMRSTDd---------------------------vLGRLQIfvnnqlaanrtaanhvyVY 474
gi 7674174    212 LMNLAettQADLCIPYVSDTNYVKTDss--------------------------dLGRLRVyvw------------tpLT 253
gi 7674174    474 ICDIGsdnSFEITIPYTFSTWMRKTNgr--------------------------pIGLFQVevlnrltynsscpnkvhCI 527
gi 195364271  182 ILDLRtntEIDLVIPYVNFRNYVEINatd------------------------svGGAICVfvlgafthgsgtsntvdYT 237
gi 3002544    176 LMNAAttsQADLYIPYVHNHNYAKTDsd--------------------------dLGGIYIwcwsaltvpsgspttvdVT 229
gi 3002544    425 DIGLNn--TFEMTIPYTWGNWMRPTRgs--------------------------vIGWLRIdvlnrltynssspnavnCI 476
gi 2493476   1800 FVDARitePVSFMIPDVRAVDYHRMDgaeptcslgf----------wvyqpllnpFSTTAVst-------------cwVS 1856
gi 18766569   308 MLDLStnnEGVLKIPFRHPRAFVRNQthktatvg--------------irpgksaSIYVQVlsplqtge--ggandmfIR 371
gi 62287092  1922 VIDARslePVTITMPDLRPNMYHPTGdpglvptlvl----------svynnlinpFGGSTSai--------------qVT 1977
                         250
                  ....*....|....*...
Feature 1           #               
1VBB_1        258 IYMKPK-HVRVWCPRPPR 274
gi 157939779  475 VTASLGpDAAFYCPRSGK 492
gi 7674174    254 IPSSATnDVDVTVLGSLL 271
gi 7674174    528 VQGRLGnDARFYCPTGSL 545
gi 195364271  238 LFGEML-ETDLQCPRPFN 254
gi 3002544    230 IFGSLL-DLDFQCPRPPG 246
gi 3002544    477 LQVKMGnDAKFMVPTTSN 494
gi 2493476   1857 VETKPGgDFDFCLLRPPG 1874
gi 18766569   372 PFYRYT-RAEFAGMSYKV 388
gi 62287092  1978 VETRPSeDFEFVMIRAPS 1995

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