1OCX,1YP4,2IU8,2NPO,1HV9,1V67,1MR9,1T3D,2PIG,1THJ,1KRV,1J2Z,1TDT,2F9C,2RIJ,2GGO,1KGQ,1KHR


Conserved Protein Domain Family
LbetaH

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cd00208: LbetaH 
Click on image for an interactive view with Cn3D
Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes showing acyltransferase activity, however, some subfamilies in this hierarchy also show activities related to ion transport or translation initiation. Many are trimeric in their active forms.
Statistics
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PSSM-Id: 100038
View PSSM: cd00208
Aligned: 24 rows
Threshold Bit Score: 49.1697
Threshold Setting Gi: 76259477
Created: 16-Aug-2001
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative trimerputative CoA
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:putative trimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the trimer structures of some members of the superfamily including E. coli Maltose O-acetyltransferase, Chlamydia Trachomatis Lpxd, and E. coli serine acetyltransferase.
  • Comment:Most characterized members of the LbH superfamily form trimeric structures in their active form. However, there are a few members that form different quaternary structures such as Glucose-1-phosphate adenylyltransferase which forms a tetramer. Hence, not all members may form trimers.
  • Structure:1OCX; Interface between monomers in Escherichia coli Maltose-O-Acetyltransferase trimer; defined at 3.5A contacts.
    View structure with Cn3D
  • Structure:2IU8; Interface between monomers in Chlamydia Trachomatis Lpxd trimer; defined at 3.5A contacts.
    View structure with Cn3D
  • Structure:1T3D; Interface between monomers in E. coli Serine Acetyltransferase trimer; defined at 3.5A contacts.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               # #   # #             #     # #                                #    ## # 
1OCX_C        73 IFLgnnFFANfdcVMLdv--cpIRIGDnCMLApgVHIYTathpidpvar-----nsgaelgkpvTIGnnVWIGGrAVINp 145 Escherichia coli
2NPO_A        99 ILImpyVVINakaKIEk----gVILNTsSVIEheCVIGEf-----------------------sHVSvgAKCAGnVKIGk 151 Campylobacter j...
1V67_A        29 VVLeekTSVWpsaVLRgdi-eqIYVGKySNVQdnVSIHTshg-------------------yptEIGeyVTIGHnAMVHg 88  Pyrococcus hori...
2PIG_A       180 AFIehrAEVFdfaLIEgdkdnnVWICDcAKVYghARVIAgtee-----------------daipTLRysSQVAEhALIEg 242 Salmonella para...
1THJ_A        45 VTIganVMVSpmaSIRsdegmpIFVGDrSNVQdgVVLHAletineegepiednivevdgkeyavYIGnnVSLAHqSQVHg 124 Methanosarcina ...
2F9C_A       107 ARIsdnVTIQs-sSVRe----eCAIYGdARVLnqSEILAiqglth-------------ehaqilQIYdrATVNH-SRIVh 167 Salmonella ente...
ZP_01000007   30 VILghgCYIGpgaSLRgdf-gkIVIGDgANVQdnCIIHSfpg-------------------rdaVVEtdGHIGHgAILHg 89  Oceanicola bats...
YP_001437809 180 AFIehrAQVFenaILEgndendVWVCDcAKIHgnARLVAgtee-----------------naspTVRysSEVSGhAVIEg 242 Enterobacter sa...
ZP_00767125  212 VFVe-aAQIEpfsYIQg----pAYIGP-GTLIasARIRAetc-------------------igpVCRvgGEVEA-SIIHg 265 Chloroflexus au...
AAK53472      50 VIVgdrVTVKcgvQLWd----gVRLGDdVFVGpnATFTNdlfprsrv---------ypekflgtVVEsgASIGAnATILa 116 Xanthomonas cam...
Feature 1                #   # # #
1OCX_C       146 gVTIGDnVVVAsGAVVT 162 Escherichia coli
2NPO_A       152 nCFLGInSCVLpNLSLA 168 Campylobacter jejuni
1V67_A        89 -AKVGNyVIIGiSSVIL 104 Pyrococcus horikoshii
2PIG_A       243 nCVLKHhVLVGgHAEVR 259 Salmonella paratyphi
1THJ_A       125 pAAVGDdTFIGmQAFVF 141 Methanosarcina thermophila
2F9C_A       168 qVQLYGnATIT-HAFIE 183 Salmonella enterica
ZP_01000007   90 -CTVGRnALVGmNAVIM 105 Oceanicola batsensis HTCC2597
YP_001437809 243 nCLLGHhVRVDeYAVIT 259 Enterobacter sakazakii ATCC BAA-894
ZP_00767125  266 ySNKHHdGFLG-HSWLG 281 Chloroflexus aurantiacus J-10-fl
AAK53472     117 gTTIGSgAMIGaGAVVT 133 Xanthomonas campestris pv. campestris

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