1F34


Conserved Protein Domain Family
API3

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cd00225: API3 
Click on image for an interactive view with Cn3D
Ascaris pepsin inhibitor-3 (API3); protein inhibitor that reversibly inhibits aspartic proteinase cathepsin E, and gastric enzymes pepsin and gastricsin.
Statistics
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PSSM-Id: 119406
View PSSM: cd00225
Aligned: 6 rows
Threshold Bit Score: 165.514
Threshold Setting Gi: 13096226
Created: 4-Sep-2001
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
protease
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:protease binding region
Evidence:
  • Structure:1F34_A _B; pepsin inhibitor-pepsin binding regions
    View structure with Cn3D
  • Structure:1F34_A _B; N-terminal residues of inhibitor occupies and blocks the S1-S3 pepsin substrate binding pockets; pepsin's catalytic Asp residues highlighted.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #####                                                                        
1F34_B        1 QFLFSMST-----GPFICTVKDNQVFVANLPWTMLEGDDiq-------vGKEFAARVEDCTNVKHDMA------------ 56
gi 905397    29 GFSVAGIG-----GTAGCVVVDNKLFANSFYLRDLTTEE----------QRELAQYVEDSNQYKEEVKtsleerrkgwql 93
gi 159891     3 GINVAGIG-----GNAGCVVVDNKLFANSFFLRELTTEE----------QRELAQYIEDSNRYKEEVKesleerrkgwql 67
gi 12275968  26 TIAVSGGAg----GSTGCVVTGNVLYANGFKLRELTPIE----------QQELQDYQNKVADYKATLKqavkerqeklka 91
gi 16943784  26 TIAVTGGVg----GSTGCVVTGNVLYANGFRLRELNPSE----------QQELVNYEKQVADYKAAVKqalkerqeslks 91
gi 71994368  11 LFPFVLPFnynngASAACIVTKNLLFSHGNLIRQLKKDEvdsfkkykkeLHVFNTKINEAFDKAEENEaknst------- 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1F34_B       57 -------------------PTCTKPPPFCGPQDMKMFNFVGCSVLGNKLFIDQKYVRDLTAKDHAEVQTFREKIAAFEEq 117
gi 905397    94 arhgekdakvlsslaekkfPKPPKKPSFCSAGDTTQYYFDGCMVQNNKIYVGRMYVRDLTSDEINQLKTFDAKMTAYQKy 173
gi 159891    68 ardgkedskvlsalaekklPKPPKKPSFCSAGDTTQYYFDGCMVQNDKIYVGRAYVRDLTPDEVTQLKTFDAKMTAYQKy 147
gi 12275968  92 rla--gkkgkavetsseelPKAPKKPSFCSPDDTTQFYFDGCMVQNNRVYVGNTYARDLTPSEIEELKVFEKKQTVYQDy 169
gi 16943784  92 rma--gkkekavtpkeedlPKAPQKPSFCTEDDTTQFYFDGCMVQGNKVYVGNTFARDLDQNEIQELKEFEKKQTVYQEy 169
gi 71994368  84 ---------------vppmPIRPTLPSFCTGADTTMYIFGACTVQNNKVYIGTVLARELEEKEKGKLADFAKKLAAVTPg 148
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                        ######     
1F34_B      118 qenqpps-----------------------------sgmphgavPAGGLSPPPPPSFCTV 148
gi 905397   174 lsssiqqqvdslfgdksnlfn-lftdtrhetssqpsdattisttTQAPVEPPETPHFCIA 232
gi 159891   148 lsstiqkqvdslfgeksnlfnlfadtrteatsqasddatagattTQAPVEAPEPPHFCVA 207
gi 12275968 170 iqkqvqqqvsnlfgssdff-----ssffgggeakqtttteapelPEEAPEQPNVPNFCTP 224
gi 16943784 170 vqkqiqaqvsnlfggadffs----sffnggsekgsstttvapvlPEDAPEQPAGPNFCTR 225
gi 71994368 149 --------------------------------------------TTPPTDIYKGLEFCTE 164

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