Conserved Protein Domain Family
p23

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cd00237: p23 
Click on image for an interactive view with Cn3D
p23 binds heat shock protein (Hsp)90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis.
Statistics
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PSSM-Id: 107218
View PSSM: cd00237
Aligned: 8 rows
Threshold Bit Score: 172.685
Threshold Setting Gi: 68369614
Created: 4-Sep-2001
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative Hsp90putative dimer
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:putative Hsp90 binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #                                            #                             
1EJF_A         3 PASAKWYDRrdYVFIEFCVEDSkDVNVNFEksKLTFSCLggsdnFKHLNEIDLFHCIDPndSKHKRTdRSILCCLRKges 82
gi 118103027   5 HAKTLWYDRprYVFLEFCVEDStDVQVVIEdhRLVFSCKna-dgVEFYNEINLYARVNSkdSREKRSdRSITCFMRKwke 83
gi 119581307  48 HARTLWYDRprYVFMEFCVEDStDVHVLIEdhRIVFSCKna-dgVELYNEIEFYAKVNSkdSQDKRSsRSITCFVRKwke 126
gi 147907146   4 QAKTLWYDRakYVFLEFCVENSrDVKVDIKkdKVIFSCLne-dnIQIYNEIQLYDKVQPldSREKRSdRSITCFLRKcke 82
gi 68369614   12 PAKTLWYDRkkYVTINFVVQNPkDVQVDVQdkKIILSCKdv-ddNNIYNEIEFYDRVLKadSREKVHdRTINVLIRKvke 90
gi 50344930    3 PAAAKWYDRrdFVFIEFLVEDSkDVKVNFDksKFGFSCLsgadnVKYSNEIDLFGSIDQdgSKHKRTdRSILCCLQKaet 82
gi 148228297   3 PASAKWYDRrdYVFLEFCVEDSkNVKTDFDknKLTFSCLggadsVKYLNEVELFQSIDPnaSKHKRTdRSVLCCLRKgep 82
gi 1362727     3 PASAKWYDRrdYVFIEFCVEDSkDVNVNFEksKLTFSCLggsdnFKHLNEIDLFNNIDPneSKHKRTdRSILCCLRKges 82
                         90       100
                 ....*....|....*....|....*..
Feature 1            ####        #   #  #   
1EJF_A        83 gqSWPRLTKERAKLNWLSVDFNNWKDW 109
gi 118103027  84 kvAWPRITKENIKPAWLSVDFDNWRDW 110
gi 119581307 127 kvAWPRLTKEDIKPVWLSVDFDNWRDW 153
gi 147907146  83 kvAWPRITKENTKPAWLFVDFDNWRDW 109
gi 68369614   91 nvAWPRLQKDTAKPAWLLVDFDNWRDW 117
gi 50344930   83 gkSWPRLTKDKAKLNWLSVDFNNWKDW 109
gi 148228297  83 gkSWPRLTKEKAKLNWLSVDFNNWKDW 109
gi 1362727    83 gqAWPRLTKERAKLNWLSVDFNNWKDW 109

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