Conserved Protein Domain Family
Lysin-Sp18

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cd00243: Lysin-Sp18 
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Sp18 and Lysin from Archaegastropoda (marine mollusks of the families Halotidae and Trochidae) sperm. Both proteins play an important role in fertilization: sp18 mediates fusion between sperm and egg cell membrane, lysin dissolves the vitelline envelope surrounding the egg; they are believed to be a product of gene duplication and subsequent divergence.
Statistics
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PSSM-Id: 119415
View PSSM: cd00243
Aligned: 26 rows
Threshold Bit Score: 118.523
Threshold Setting Gi: 12084519
Created: 4-Sep-2001
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1GAK_A        6 VSRQEQSYVQRGMVNFLDEEMHKLVKRFrdmrwnLGPGFVFLLKKVNRERMMRYCMDYARYSKKILQLKHLPVNKKTLTK 85
gi 538392    28 LSKAKLSALKTQIIAGFDRKLASWLRRHgn---rLSAIQKKTLYFVNRRYMQTHWRSYMKFVRNQMKLLGRAETTADYNR 104
gi 604527    23 VSKENAAAMKIAMIKFLDARAGKFKKRVenmgypITPPQWTTLLYYNRQRLMEWCHTYVEFSKKIILMGGNKLNKKNFTR 102
gi 604525    23 VSKENAAAMKVAMIKFLDSRTDRFKKRIekigypITPPQYTTLLYYNRERLMDWCHNYVEVSKKIILLGGNKLNKKNFAR 102
gi 10566723  37 FGYENNGIVKTAIVRVMDRFSDAYVRKHp-----SARRYLDYMRFLNRRKVYNTWNNWSNWCRNRIRELNRRPTARDFRS 111
gi 604533    23 VSKENEAAMKVAMMKFLDMKAGVFKEIIedmgypITPPQWTTLLYYNRERLIEFCRSFLALSKKIILLGGNKLNKANFAR 102
gi 4704770   22 FGNTEEVWIKGTLIHELDKKANAYCQKHp-----TIRMYRDYMLYQGRQKLYNSWNNWSQWFAREIKKLGRSPTRNDYVN 96
gi 4704776   37 FGRVNNGLIKGGMFLEMDNVAKRFCRKHp-----SAKPYFQYMRYLNRQRIYGNWNNYSQWARGLVQKLGRKPTSREFAN 111
gi 4704774   34 FGGVNNGVMKTAIVKALHKKATVWCRQHp-----HGRPYEPFMRFMNVQRVYTNWNNMSTWAVKELRKMHRRPVTRDYEN 108
gi 604529    23 VSRQEQSYVQRGMVNFLDEEMHKLVKRFrdmrwnLGPGFVFLLKKVNRERMMRYCMDYARYSKKILQLKHLPVNKKTLTK 102
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
1GAK_A       86 MGRFVGYRNygvIRELYADVFRdvqgfrgPKMTAAMRKYSSKDPGTFPCK 135
gi 538392   105 VGAAIGKRIp--LEITYSFLVRrn---liPKWKPYMARLMARRPGDIPTS 149
gi 604527   103 MGRIIGWKNqwvLKRRQWEMVRvm---rrYKSTAIAKKIVAMKVADLPCN 149
gi 604525   103 MGRIIGWKNqwiLKRRQWHMVRvm---rrYKASAIAKKIVAMKVADLPCN 149
gi 10566723 112 FGERLGNMCrfqMNFMYDVIVKe-----rCKLNAHQRRFLNTPPRDMPIR 156
gi 604533   103 MGRILGWKSqwaVRQRQWGMVRvs---rrHTSTAIAKRIVAMKVADLPCN 149
gi 4704770   97 LARRLGRDVf--MRHLYEAAWKy-----kLKLNPDKRNMLRIPIYKFPVR 139
gi 4704776  112 IGRKMGKEMd--CEAYFRIVVRy-----rLKLNPDKRKLLNTPAIDFPIR 154
gi 4704774  109 LGRRIGEHTy--MRHVYEVVSEm-----rIRPTPDQIRFTNIKPANLPLR 151
gi 604529   103 MGRFVGYRNygvIRELYADVFRdvqgfrgPKMTAAMRKYSSKDPGTFPCK 152
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