Conserved Protein Domain Family
Mth_Ecto

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cd00251: Mth_Ecto 
Click on image for an interactive view with Cn3D
The ectodomain of Methuselah (Mth); Mth mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage; The protein affected by this mutation is related to G protein-coupled receptors of the secretin receptor family; Mth, like secretin receptor family members, has a large N-terminal ectodomain, which may constitute the ligand binding site.
Links
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Statistics
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PSSM-Id: 119403
View PSSM: cd00251
Aligned: 18 rows
Threshold Bit Score: 190.581
Threshold Setting Gi: 58388436
Created: 4-Sep-2001
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:N-linked glycosylation sites [posttranslational modification site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        #                                                               
1FJR_A         5 CDYFDTVDISAAQKLqNGSYLFEGLLVPAILTGEYDFRILp-DDSKQKVARHIRGCVCKLKPCVRFCCPHDHIMDng--v 81
gi 17369813   30 CAFIDTANITGSYGL-DGPFVHNWTVIPRHFVAVYDFVIE--NGIRIPASRHLRACVCKTKPCVRICCLRGEIYDlekrq 106
gi 17369809   29 CAYAHTVNITDGLRMkDGSYSYAGVVVPPHLMAEYSFKVI--DGVEYRAKKHLRGCVCLLKPCISFCCPENLVFDakhwn 106
gi 194746850  53 CKFHDTVNLTGHTRFpNGSYEYEGIIIPEHLVGNYDYVFRs-LADRVEVPNHVRGCVCKLKPCLNICCPWGQIYNsgrge 131
gi 198462592 168 CDYFDTVNVTGSQRLvNGSYLYQGVVIPAELTAEFDYRVLp-DDSTEPVERHLRGCVCQLRPCLRLCCHHSQLMAng--q 244
gi 195435976  27 CNYYDTVDLTGIQPFkNGSYPYENIIIPADLIGEYDYRLTgvDDERIEVPKYIRGCACRLKSCVRFCCHHNLMFMng--e 104
gi 194865297  27 CNYYDTVDISNVERQ-NDSYLYDDIRIPASLTGDYEYKQYr-DLSREPVKKHLRACVCSLRPCIRICCPAKYILAng--k 102
gi 28574381   25 CDYFDTVDISHIPKL-NDSYAYEELIIPAHLTGLYTFRQLa-DGSQEPVKSHLRACICKLKPCIRFCCPRNKMMPns--r 100
gi 195388728   7 CDYFDTVDLTNSHKFeNGTYLYEDILIPKEKVGLYDYQILf-NGDREPVPEHTRGCACQIKSCVRFCCDPQKLLVkgegi 85
gi 170057118  25 CDFIDSVNITDGVRDsAGNIIHNNILYKPKYFRTIDYDYEh-FSRKKFVAEYIRGCPCAVRLCIRMCCPYGTVFFqr--k 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         #                                                       #      
1FJR_A        82 CYDNMSdeelaeLDPFLNVTLd-----dGSVSRRhf-knELIVQWDLp-mPCDGMFYLDnre--eqDKYTLFENGTFFRh 152
gi 17369813  107 CLVPVAgvsslpSHSHMEVELg-----nGSLRLVkl-qpRFSIHVET---PCEHMKAVTkgs--eyVHWTLHENGTISH- 174
gi 17369809  107 CTMPHQv----rESTHVELTYa-----nRTVDQVri-rdRFVVRTEL---GCRNKFVDKkhd--nfWQWDLFENGTLRR- 170
gi 194746850 132 CMNDTMdhr-ewPKPVLNVTFa------ENITMEvnisqQFAVQSFR---PCAKMFSLQpei-ndfDAYLIFQNGSMFRv 200
gi 198462592 245 CSGSIEvdl-trLNPYLNVTLd-----dGTVARRhf-qeEFIIQSDLp-iPCNDMYPLNdqe--eqDQYIVFENGSFFRp 314
gi 195435976 105 CIGDTDka--leYDPYLNITTs-----dGSVVEKhv-lnEFVVQRHLp-lPCSEIGTYHlddriegYEWSLFENGSFKRt 175
gi 194865297 103 CGDGLQeel-arYESYIYLTSm-----nLTIDERvp-ltEMTIIRDHf-lACDEMMHLT-------DEYDYLEDGTLRIs 167
gi 28574381  101 CSDGLTenl-krINPYLKITLe-----dGTIGKYyl-ltDMIVLRYEf-rYCEKVVSVQe------DQYKLYENGSFMIk 166
gi 195388728  86 CEGNINl----nYSSILNITMh-----dGAEVEKdv--mEFIVQKHLp-vPCNDHLMLNaag-nenHGWTLFENGTLVRh 152
gi 170057118 102 CVPTESq-----LVVNVNTTLynsnrssEVVDLT-----QNQMYGFLygkPCESVYQLDpen--spEDEWIFARNGSII- 168
                        170       180       190
                 ....*....|....*....|....*....|....
Feature 1                                          
1FJR_A       153 FDr-VTLRKrEYCLQHLTFadgnatSIRIAPHNC 185
gi 17369813  175 RG--HIFSK-HYCFTPLLHgn---sTWEWQPLAC 202
gi 17369809  171 DN--RLWSTdEYCFSPLEHnp---eQWELTPLNC 199
gi 194746850 201 DDk-VFIEKnQYCLVPTFVnes-dlVYSLNPANC 232
gi 198462592 315 YDs-ATMSKrEYCLQAYDFregeteSFRIVAHNC 347
gi 195435976 176 FDg-VSLDKrEYCLQPVELpd---rEIRLVPHNC 205
gi 194865297 168 DD--RYIEKqEYCLYPYQFnsdfpkSMWIVVHRC 199
gi 28574381  167 PDvnWTLSKqWYCLHPRLEdp---nSIWILEHVY 197
gi 195388728 153 FDg-EHLSKrDYCLQPIHRpns-qlLYELQPHHC 184
gi 170057118 169 YDs-RLMTRnQFCFMQNNN------SEPVIPYIC 195

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