1SRA,1NUB


Conserved Protein Domain Family
EFh_SPARC_EC

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cd00252: EFh_SPARC_EC 
Click on image for an interactive view with Cn3D
EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins
The SPARC protein family represents a diverse group of proteins that share a follistatin-like (FS) domain and an extracellular calcium-binding (EC) domain with two EF-hand motifs. It includes SPARC (for secreted protein acidic and rich in cysteine, also termed osteonectin/ON, or basement-membrane protein 40/BM-40), SPARC-like protein 1 (for secreted protein, acidic and rich in cysteines-like 1/ SPARCL1, also termed high endothelial venule protein/Hevi, or MAST 9, or SC-1, or RAGS-1, or QR1, or ECM 2), testicans 1, 2, and 3 (also termed SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycans, or SPOCK), secreted modular calcium-binding protein SMOC-1 (also termed SPARC-related modular calcium-binding protein 1) and SMOC-2 (also termed SPARC-related modular calcium-binding protein 2, or smooth muscle-associated protein 2/SMAP-2), follistatin-related protein 1 (FRP-1, also termed follistatin-like protein 1/fstl-1, TSC-36/Flik, TGF-beta inducible protein). The SPARC proteins have been implicated in modulating cell interaction with the extracellular milieu, including regulation of extracellular matrix assembly and deposition, counter-adhesion, effects on extracellular protease activity, and modulation of growth factor/cytokine signaling pathways, as well as in development and disease.
Statistics
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PSSM-Id: 320009
View PSSM: cd00252
Aligned: 11 rows
Threshold Bit Score: 102.45
Threshold Setting Gi: 2498390
Created: 4-Sep-2001
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1SRA_A         3 CLDSELTE-FPLRMRDWLKNVLVTLYerdednnlltekqklrvkkihenekrleagdhpvellardfeknynmYIFPVHW 81
gi 156373068 113 CARDNLLQ-FGERYLEWILISRRRLVnryyqvkese----------------------------kghnlppdmRKELAQW 163
gi 156364615 112 CPKWMLEQ-FPYRFLDWLYLTRELSRdprfeiakr------------------------------geqltgdeIKEVLAW 160
gi 585670300 109 CSADEYMQ-FPHRLLLWFVHLKEIDEfgsihpdss------------------------------lrtmdvaeREEIAKW 157
gi 156228680 103 CPGIDHMSqFRDRYLEWAHVAKEQTKdqnytltrr------------------------------ihdmtmrqKVAIAKW 152
gi 642130006 124 CTEEEYGQ-FPYRLMDWFLLLSRMGEtyapyapp-------------------------------qsclshtqRSQLAQR 171
gi 198429553 126 CQSHELQQ-FPFRLLDWFVHLKDVDEfgsvdyqkt------------------------------vmslsetdRKDVAQW 174
gi 24212500  199 CTGQDLAD-LGDRLRDWFQLLHENSKqngsassvagp-------------------------asgldkslgasCKDSIGW 252
gi 677467272 156 CPEGKKVE-FITSLLDALTTDMVQAInsaaptgggr---------------------------fsepdpshtlEERVVHW 207
1NUB_A        89 CLDSELTE-FPLRMRDWLKNVLVTLYerdednnlltekqklrvkki--------henekrleagdhpeknynmYIFPVHW 159
gi 2498390   113 CYQSNRDE-LRRRIIQWLEAEIIPDGwfsk----------------------------------------gsnYSEILDK 151
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
Feature 1             #    #      #                                      # # #      #       
1SRA_A        82 QFGQLDqhpIDGYLSHTELAPLRAPLi----------------pMEHCTTRFFETCDLDNDKYIALDEWAGCFGI 140
gi 156373068 164 EFDRVDf-nRDGVLSGREINSIIGPLl----------------fHERCIYGFVMSCDVNKNSVIDKQEWLLCFPA 221
gi 156364615 161 EFNNWDl-nKNGIWDKEELDLVQTILm----------------pIEGCSFGFLKSCDLDGKGDMDRREWMMCFPE 218
gi 585670300 158 KFDLLDr-kGDGKLDRRDLRDFRYALm----------------pLEHCADEFFKSCDVDNNVKLTLDEWYDCLKV 215
gi 156228680 153 EFDRNDl-dKDNALEGAEIDNILAMMi-----------------YEPCAAGFLWSCDLNRKQGISRSEWDMCFTL 209
gi 642130006 172 RFGLLDk-nKDGKLSRKDLRKLRYKRm----------------pLEHCATSFFQSCDHNKNTKVTLHEWISCLVD 229
gi 198429553 175 KFQHLDr-nKDGKLSNKEIKRFRFALm----------------pLEHCAKHFFKKCDLDKNRKLSSDEWSECLVT 232
gi 24212500  253 MFSKLDt-sADLFLDQTELAAINLDK------------------YEVCIRPFFNSCDTYKDGRVSTAEWCFCFWR 308
gi 677467272 208 YFSQLDn-nSSNDINKRELKPFKRYVkkk-------------akPKKCARRFTDYCDLNKDKSISLQELKGCLGV 268
1NUB_A       160 QFGQLDqhpIDGYLSHTELAPLRAPLi----------------pMEHCTTRFFETCDLDNDKYIALDEWAGCFGI 218
gi 2498390   152 YFKNFDn--GDSRLDSSEFLKFVEQNetainittypdqennkllRGLCVDALIELSDENADWKLSFQEFLKCLNP 224

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