Conserved Protein Domain Family
ACD_sHsps_p23-like

?
cd00298: ACD_sHsps_p23-like 
Click on image for an interactive view with Cn3D
This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is this ACD. sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps. p23 is a cochaperone of the Hsp90 chaperoning pathway. It binds Hsp90 and participates in the folding of a number of Hsp90 clients including the progesterone receptor. p23 also has a passive chaperoning activity. p23 in addition may act as the cytosolic prostaglandin E2 synthase. Included in this family is the p23-like C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1) and the p23-like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR).
Statistics
?
PSSM-Id: 107219
View PSSM: cd00298
Aligned: 1146 rows
Threshold Bit Score: 27.5535
Threshold Setting Gi: 67620720
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1GME_A        48 WKETpeAHVFKADLPGvk---keEVKVEVEdgnVLVVSGErtkekedkndkwhrverssGKFVRRFrLLEDAKVe---eV 121
gi 19921134    4 ISQTeeDIKISIELNRlv---trKPDVVLL---PQYLKFNn------------------PPIFFERhLAQEIDEm---aS 56
gi 91092102   10 WSQTdnTVTIKVPLRGih---hsKVDIFYS---KLYIKASf------------------EQYFFEVfLYKQIDPk---tS 62
gi 95007080    9 WSETsdTVAFALCIPVlssfhtpDVRRIIS---PLYIRISs------------------PPYFFEVdLFDEIDDe---tV 64
gi 74026192   30 WEQTntEVLLRITIKGfk---keAIDIFVS---DLLVKVNa-----------------sPTYLLVLdLLHPIDEa---kS 83
gi 146096912   9 WEQTgeDVLLHITIKGck---kdAVDVLIA---DVFVKVNa-----------------pPQYLLALdLLHAIDSs---kS 62
gi 118348986  28 WYQDnkIVKIRIPIKGit---mkKIDIFIS---DLVLKINit----------------eKKWVRVLdLKHEIDFqgqenN 85
gi 147676965 103 VFETagEVSIHIVLPElas--rnDLALFISp-eALELSGTmvcggta------ggdkrtENFHKTVrLPAPVDPs---gA 170
gi 157692725  55 VTEDeqFVYIAIQFPDhfv--egDIALEVKa-qYLHLSVQetiktd--------tassySSFTKTIlMPAKIDEt---nM 120
gi 3913296    44 LYETsqQYIIEADLTFlq---ptQVTVTLSg-cEFILTVKss----------------gQTFEKQMmLPFYFNDk---nI 100
                         90
                 ....*....|....*....
1GME_A       122 KAGLEn----GVLTVTVPK 136
gi 19921134   57 FCRIFk----NEARIVLVK 71
gi 91092102   63 SCTFTs----THILFELIK 77
gi 95007080   65 DASLSg----AHLVLRLRK 79
gi 74026192   84 THFMDpe-drTCLRVRLRK 101
gi 146096912  63 SQYFTdaqdgIILHVKLHK 81
gi 118348986  86 VVYAN-----EVLEIILVK 99
gi 147676965 171 SAVYRn----GTMYVRAPK 185
gi 157692725 121 KSVWKd----QTLRVTAPK 135
gi 3913296   101 QVECEn----QILTVAVNK 115
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap