Conserved Protein Domain Family
FNR_like

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cd00322: FNR_like 
Click on image for an interactive view with Cn3D
Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in many organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one- electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and 2 electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).
Statistics
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PSSM-Id: 99778
View PSSM: cd00322
Aligned: 86 rows
Threshold Bit Score: 79.4132
Threshold Setting Gi: 110590386
Created: 31-Jul-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:FAD binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                              #                                         
1A8P_A        10 LSVHHwn-----dtLFSFKTTrnp------slrFENGQFVMIglevd-----------------------------grpl 49
1GAQ_A        43 LLNTKitgddapgeTWHMVFSteg------kipYREGQSIGViadgvdk-------------------------ngkphk 91
1QFJ_A         8 TSVEAit-----dtVYRVRIVpda------afsFRAGQYLMVvmde--------------------------------rd 44
1TVC_A        16 VGLNWvs-----snTVQFLLQkrpdecgnrgvkFEPGQFMDLtipg-------------------------------tdv 59
2GPJ_A        14 IRSTYit-----phXLRITLGgagla---gfpaDQESAYIKLlfpqag----------------------------erpl 57
2R6H_A        15 LSNKNvs-----tfIKEFVVKlpeg----etxnFKSGSYAQIkipkyniryadydiqdrfrgdwdkxdawsltckneeet 85
gi 1840137   120 VATEPlt-----hdILKVTIQtdr------pvhYLAGRYANVrvpg-------------------------------wpr 157
gi 116332606  10 VKNIVkt-----dgSATITFVskng-----plnFLGGQYVIFnsglktp--------------------------egkvi 53
gi 119897511 115 VGISAlt-----hdIRRLDVEleq------pirFWAGQFVDItlpe-------------------------------kgi 152
gi 119898141 110 SRIESlt-----ptIKGVWVKldep----egmrFQAGQYINLhlpd-------------------------------gig 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ####                 ###                   ####                                
1A8P_A        50 mRAYSIASpnye-----ehlEFFSIKVq---------------nGPLTSRLqhl-keGDELMVSrkptgtlvtsdllpgK 108
1GAQ_A        92 vRLYSIASsaigdfgdsktvSLCVKRLiytnda------geivkGVCSNFLcdl-qpGDNVQITgpvgkem-lmpkdpnA 163
1QFJ_A        45 kRPFSMAStpde----kgfiELHIGASe---------------iNLYAKAVmdrilkDHQIVVDiphgeaw--lrddeeR 103
1TVC_A        60 sRSYSPANlpnp----egrlEFLIRVLp---------------eGRFSDYLrndarvGQVLSVKgplgvfg--lkergmA 118
2GPJ_A        58 xRTYTIRQqrd------deiDVDFVLHdt--------------dGPASSWAkta-qvGELIQIGgpglkk---linfeaD 113
2R6H_A        86 vRAYSXANypae----gniiTLNVRIAtppfdraankwkagikpGISSSYIfsl-kpGDKVXXSgpygdf---hiqdtdA 157
gi 1840137   158 fRCYSFANapqrk--grnvlEFYIRKVp---------------aGEFTEALfrgeldGQPLEMEapqgtf---hlhggdA 217
gi 116332606  54 kRAYSIFSsdl------qqeEFQICIQpi-------------qgGPASNHIpnl-aiGSVLEFSgpwgkfignpdwpkkG 113
gi 119897511 153 tRSYSMASvpss----pgqvSFIIKKYp---------------nGAFSTALdtelkpGDPVLVKgpyggcf--rreerpG 211
gi 119898141 150 tRAFSIASapsa----ageiELNIRIVa---------------gGQGTAYVheklkaGDAIRITgpygrff--vkksakV 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                #                                                                       
1A8P_A       109 HLYMLSTGTGLaPFMSLIQDpevye-----rfekVVLIHGVRqvnelAYQQFItehlpqseyfgeavkeklIYYPTVtre 183
1GAQ_A       164 TIIMLATGTGIaPFRSFLWKmffekhddykfnglGWLFLGVPtssslLYKEEFgkmker-------apenfRVDYAVsre 236
1QFJ_A       104 PMILIAGGTGFsYARSILLTalarn-----pnrdITIYWGGReeqhlYDLCELealsl--------khpglQVVPVVeqp 170
1TVC_A       119 PRYFVAGGTGLaPVVSMVRQmqewt-----apneTRIYFGVNtepelFYIDELksler--------smrnlTVKACVwhp 185
2GPJ_A       114 WFLLAGDXTALpAISVNLAKlpn--------navGYAVIEVLse--aDIQPLVhpe-------------hvELHWVInpe 170
2R6H_A       158 EXLYIGGGAGXaPLRAQILHlfrtl----ktgrkVSYWYGARskneiFYEEDFreier--------efpnfKFHIALsdp 225
gi 1840137   218 PMLCIAGGSGLaPLVSILEHaranr-----ikrdCILLFGARtegdlYQLEAIgniaan-------wqgefRFIPVLshe 285
gi 116332606 114 RTLLVATDTGItAINSILHSsrwkfk---lkettVLWFLFPKek-svPVQEVLqrlp-----------kefHFLNVIhip 178
gi 119897511 212 PMVLIGGGSGMsPLWSILNDhiesg-----eqrpIRFFYGARtrrdlFYLEQFaefeq--------kvpdfRFIPALsaa 278
gi 119898141 209 PVVFMAGGSGLsSPRSMILDlleeg-----fdlpITLVYGQRsraelYYHDEFlalaq--------rhpnfRYVPALshe 275
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                                                                                    
1A8P_A       184 sfhnqgrltdlmrsgklfediglppinpqddraMICGSpsmldESCEVldgfglkis-------prmgepgdYLIE 252
1GAQ_A       237 qtnaagermyiqtrmaeykeelwellkkdntyvYMCGLkgmekGIDDImvslaekdgidwfdykkqlkrgdqWNVE 312
1QFJ_A       171 eagwrgrtgtvl------tavlqdhgtlaehdiYIAGRfemakIARDLfcsern-------------aredrLFGD 227
1TVC_A       186 sgdwegeqgspid-----alredlessdanpdiYLCGPpgmidAACELvrsrg--------------ipgeqVFFE 242
2GPJ_A       171 adpegrplver---------iaqlpwlagepavWIACEfnsxrALRRHfkqaha-------------lpkshFYTS 224
2R6H_A       226 qpednwtgyvgfihqviydnylkdhdapedieyYXCGPgpxanAVKGXlenlg--------------vprnxLFFD 287
gi 1840137   286 pehsdwtgargl------vtehipadfcegaegYLCGPppmidAAIARlldnr--------------lplekIFYD 341
gi 116332606 179 kinhpnrkeecir-----sfiekldssmfptsaFLAGDgklirALKDIllmrg--------------mneedIGME 235
gi 119897511 279 epedgwtgetgyihevvartlkeegfdgasidaYTCGPapmidAITPVlhmag--------------vppdqMYFD 340
gi 119898141 276 pegsdwngfrgfvh---eaakaafdndfrghkaYLCGPplmidACITTlmqgr--------------lferdIYME 334

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