Conserved Protein Domain Family
PurM-like

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cd00396: PurM-like 
Click on image for an interactive view with Cn3D
AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain of AIR synthase forms the dimer interface of the protein, and is suggested as a putative ATP binding domain.
Statistics
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PSSM-Id: 100027
View PSSM: cd00396
Aligned: 10 rows
Threshold Bit Score: 172.581
Threshold Setting Gi: 55669841
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP bindingdimerization
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:The N- and C-terminal repeats of PurL bind ATP/ADP
  • Structure:1T3T; Salmonella FGAR-AT with bound ADP, 3.5 A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        #   #                                            
1CLI_A         59 VLVSGTDGVGtklrlamdlkrhdTIGIDLVAMCVNDLVvqg---aepLFFLDYYATgkld-------------------- 115
1VK3_A         76 SVAFKIESHNhpsa-----iepyNGAATGVGGIIRDVLaxg---arpTAIFDSLHXsr---------------------- 125
1T3T_A        296 HILMKVETHNhpta-----ispwPGAATGSGGEIRDEGatgr-gakpKAGLVGFSVsnlripgfeqpweedfgkperivt 369
2Z1T_A         50 PLAMSTDSYTvdpif----fpggDIGTLAVHGTVNDVSmlg---arpRYLSCGFILeegl-------------------- 102
1T3T_A        700 GEAMSIGERApval-----ldfaASARLAVGEALTNIAatqigdikrIKLSANWMAaaghp------------------g 756
gi 118726187   45 ACVMSTDPITaa---------gkNAGRLAVHISCNDIAssg---vepLGLMVTILCpvgt-------------------- 92
gi 84489827    57 LMLLATDGIWgalmd----vnpwWAGYCSVLVNVNDIAamg---grpMGMTNVLSSsnp--------------------- 108
gi 134423      62 SVISTTDFFMpivd------npfDFGRIAATNAISDIFamg---gkpIMAIAILGWpinkl------------------- 113
1VQV_B         37 KLLLTTDVLNegvhfl-rsyipeAVGWKAISVNVSDVIang---glpKWALISLNLpedl-------------------- 92
gi 2622644    137 YITTAVDGIHsrls-----eypfLGGFHVTRAALRDVCvmg---srpVALISDLHLaddg-------------------- 188
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  ###                                                    
1CLI_A        116 -vdtASAVISGIA-EGCLQSGCslVGGETAEmpgmy---------hgedYDVAGFCVGVVekseiid-gskvsdgDVLIA 183
1VK3_A        126 ---iIDGIIEGIA-DYGNSIGVptVGGELRIssly-----------ahnPLVNVLAAGVVrndxlvd-skasrpgQVIVI 189
1T3T_A        370 aldiMTEGPLGGA-AFNNEFGRpaLTGYFRTyeekvnshngeelrgyhkPIMLAGGIGNIradhvqk--geivvgAKLIV 446
2Z1T_A        103 dmdiLERVVASMG-KAAREAGVfiVTGDTKVvprg----------acdkMFINTTGIGEIlvdpaps-gdrarpgDAILI 170
1T3T_A        757 edagLYDAVKAVGeELCPQLGLtiPVGKDSMsmktrwqegneqremtspLSLVISAFARVedvrhtltpqlstedNALLL 836
gi 118726187   93 teteLEHLMDQVC-ETAGQLNVeiIGGHTEVtpav----------nkiiLSTTCVGKSLKdkiiss---sgakpgDSVIL 158
gi 84489827   109 --eiTAQIMDGIK-EGVKKFGVpmVGGHTHPdt--------------pyDALDVAISGIVdkdavip-scgavndDNVIV 170
gi 134423     114 speiAREVTEGGR-YACRQAGIalAGGHSIDap---------------ePIFGLAVTGIVptervkk-nstaqagCKLFL 176
1VQV_B         93 evsyVERFYIGVK-RACEFYKCevVGGNISKse---------------kIGISVFLVGETerfvgr---dgarlgDSVFV 153
gi 2622644    189 dvgkLFDFTAGVA-AVSELVGVpvVAGSTLRvggdm--------vlgdrLVSAVGAIGFSetpptar--kraepgDVILL 257
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
1CLI_A        184 LGssgphsngyslvrkilevsgcdpqtteldgkpladhllaptriyVKSVLELiekv------------dvhAIAHLTgg 251
1VK3_A        190 FGgatgrdgihgasfasedltg-----dkatklsiqvgdpfaekxlIEAFLEXveeg------------lveGAQDLGag 252
1T3T_A        447 LGgpamniglgggaassmasgqs---dadldfasvqrdnpemerrcQEVIDRCwqlgd---------anpilFIHDVGag 514
2Z1T_A        171 SGsmgdhgltilsqrqg---------------lnfaadvcsdsaslNRVVEKLvlev-----------gdihVLRDPTrg 224
1T3T_A        837 IDlgkghnalgatalaqvyr--------qlgdkpadvrdvaqlkgfYDAMQALvaar------------kllAWHDRSdg 896
gi 118726187  159 TKsaglegtaiiagd------------------feeelaevmnkneLQYAKSLinaisvvpegvlagrfgvtSMHDITeg 220
gi 84489827   171 AIdldgdvypgteinwd--------------ttsdkspsyvqnqinVMETIGKkhl--------------vhAAKDISnp 222
gi 134423     177 TKplgigvlttaekksl---------------lkpehqglatevmcRMNIAGAsfani----------egvkAMTDVTgf 231
1VQV_B        154 SGtlgdsraglelllxekee--------yepfelaliqrhlrptarIDYVKHIqky--------------anASXDISdg 211
gi 2622644    258 TEgsgggtittta----------------------iyhglfdvvweTLDVNFIraseaimd---sgllgdvhAMTDVTng 312
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
1CLI_A        252 gfwenIPRVLpd-nTQAVIDesswqwpevfnwlqta--------------------gnvehhemyrtfncgvGMIIALpa 310
1VK3_A        253 gvlsaTSELVakgnLGAIVHldrvplrepdxe-----------------------------pweilisesqeRXAVVTsp 303
1T3T_A        515 glsnaMPELVsdggRGGKFElrdilsdepgms-----------------------------pleiwcnesqeRYVLAVaa 565
2Z1T_A        225 glattLNEIAgqsqAVCHVLetavpvresvrngc------------------------sflgldplylanegKLICILpe 280
1T3T_A        897 gllvtLAEMAfaghCGVQVDiaalgddhl-----------------------------------aalfneelGGVIQVra 941
gi 118726187  221 gvlgaAWEIAeassTGVTIKkdsipvepvtrhic------------------------dhfginplrlissgCMIITCkd 276
gi 84489827   223 givgtLGMLLeasdMGAHIDlesiprandidw-----------------------------iswfkmypgsaFVLTAPee 273
gi 134423     232 gllghLSEMCqgagVQARVDyeaipklpgveeyiklgavpggternfasyghlmgemprevrdllcdpqtsgGLLLAVmp 311
1VQV_B        212 l-vadANHLAqrsgVKIEILseklplsnelkxycek--------------------ygknpieyalfggedyQLLFTHpk 270
gi 2622644    313 glrgdAHEISstagVGLEFDadavmsminpsvlrm-----------------------lqdleidplgvsidSLMIIApe 369
                         330       340
                  ....*....|....*....|....
Feature 1                                 
1CLI_A        311 pevdkal--allnangenAWKIGI 332
1VK3_A        304 qkasril--eiarkhllfGDVVAE 325
1T3T_A        566 dqlplfd--elckrerapYAVIGD 587
2Z1T_A        281 eraeaalavlregphgehAARIGS 304
1T3T_A        942 edrdaveallaqygladcVHYLGQ 965
gi 118726187  277 geglvr----llgennikASIIGT 296
gi 84489827   274 ttdetls---llnkahidANCVGK 294
gi 134423     312 eaenevk--ataaefgieLTAIGE 333
1VQV_B        271 erw----------npfldXTEIGR 284
gi 2622644    370 dvapdvm--dtirgagvdVAEIGR 391

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