Conserved Protein Domain Family
YjgF_YER057c_UK114_family

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cd00448: YjgF_YER057c_UK114_family 
Click on image for an interactive view with Cn3D
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Statistics
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PSSM-Id: 100004
View PSSM: cd00448
Aligned: 852 rows
Threshold Bit Score: 31.3747
Threshold Setting Gi: 159125167
Created: 31-Jul-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
homotrimerputative active
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:homotrimer interaction site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  # #     # # ##                                                 # ## # #     
1JD1_A        20 YSHAMKVn---nLIFLSGQIpvtpdn-----------klvegsIADKAEQVIQNIKNVLEASnssldRVVKVNIFLadin 85
gi 146417143  16 ILSPAYIsn--gLVLSSGSVgvrsdg------------vvaetAAEQTTLAIENMKTVLEKSgsnlnKVVKVLLFItdek 81
gi 49658063   18 VLGPAWKsn--gHVFTSGIVgqnyan-----------gripesLEEQTELAIANVKKVLEASgssldKVFKVLMFIshsd 84
gi 50304483   19 LAPAYVTskdteLVYTSGCVgsdllt-----------geipedLEKQVRNALDNLGRVLKASnssfdDVLKILLFVadgs 87
gi 50308247   20 SPGFATEsg-nqLLFSSGCVgtdpvt-----------nelpedLEQQARNSMINLKKVLEVSgssvdSVLKILLFVsdgs 87
gi 154301863  35 FSHSNTIpsnrsTVYLSGIMgdlpgdg----------riisggATAQTTQIMRNLKAILEASgsgldKVVQRRVFLvdmg 104
gi 94972476   17 YPQNILTn----ECIYLCELprdpst-----------ntipetIEEQTQQVMKNIEASLAASglgfhHVTKVSITLvnps 81
gi 156742587  18 YDQAIRVg---nMVITSSYMglhpsha----------giitggFEAEFRQAMHNIAAVLAAAgctlrDVVRVNVSLtdlq 84
gi 86135579   11 YPHVKVVg---dFIFVSGTSsrrpdnsiagvdiidemgtkrlnAETQTREVLKNIDRNLQTVgaslkDVVDVSSFLvnmn 87
gi 91783977   13 YPAVKIFg---nLIFVSGISarlpdnrvagv--eqiggqikgdAAIQTQVILDKLDALLQEHgscleECLDVTAFLtdmd 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
Feature 1             #  #         ########          # # # 
1JD1_A        86 HFAEFNSVYAKYfnt-hkPARSCVAVaal-plgVDMEMEAIA 125
gi 146417143  82 DSKVVNEVYHKYfp--hlPARSCVIVkfp-stsLKVELECVA 120
gi 49658063   85 YSATVNKIYGKHfp--qkPARSCVVVafm-daaIKVELEVVA 123
gi 50304483   88 YASTVNAVYKEYfp--erPARSCIVVsfp-dptLKVELECVA 126
gi 50308247   88 YAGIVNKVFKEFfp--nqPARSCIVVafp-nnkLKVELECIA 126
gi 154301863 105 DLKIVDRIWGEWvke-pfPVSTCVQIvrlakeaARLEIEVVA 145
gi 94972476   82 NYKLVKRIYDHFflgynpECRFHAASmlr--ehSQIEVEVVA 121
gi 156742587  85 KYTEMDRLYREYfhp-pyPTRRTIGVkel-lggAQVEIDVWA 124
gi 86135579   88 DFAGYNKAYAEFfdketgPTRTTVAVhqlphpdLVVEIKVTA 129
gi 91783977   88 DFPAFNRVYAEHfrietgPARTTLAVkalpkpgMVVELKVVA 129

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