Conserved Protein Domain Family
Ribosomal_L24e_L24

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cd00472: Ribosomal_L24e_L24 
Click on image for an interactive view with Cn3D
Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor binding site. L24e/L24 appears to play a role in the kinetics of peptide synthesis, and may be involved in interactions between the large and small subunits, either directly or through other factors. In mouse, a deletion mutation in L24 has been identified as the cause for the belly spot and tail (Bst) mutation that results in disrupted pigmentation, somitogenesis and retinal cell fate determination. L24 may be an important protein in eukaryotic reproduction: in shrimp, L24 expression is elevated in the ovary, suggesting a role in oogenesis, and in Arabidopsis, L24 has been proposed to have a specific function in gynoecium development. No protein with sequence or structural homology to L24e/L24 has been identified in bacteria, but a functionally equivalent protein may exist. Bacterial L19 forms an interprotein beta sheet with L14 that is similar to the L24e/L14 interprotein beta sheet observed in the archaeal L24e structures. Some eukaryotic L24 proteins were initially identified as L30, and this alignment model contains several sequences called L30.
Statistics
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PSSM-Id: 100103
View PSSM: cd00472
Aligned: 72 rows
Threshold Bit Score: 61.4342
Threshold Setting Gi: 33772491
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:23S rRNA interface [nucleic acid binding site]
Evidence:
  • Structure:1S72_U; Haloarcula marismortui ribosomal protein L24e binds 23S rRNA (1S72_0), defined using 3.5 A contacts
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                        ##                   ## ##   # #     ##   
1S72_U         1 PRTRECDYCGTDIEPGTGTMFVHK----DGATTHFCSSKCENNADLGREARNLEWTDT 54
gi 67592058    8 IKTDLCSYSEYRIYPGRGRKFVAR----DGRVSTFLNQKCASLFHQKIRPVKLKWSVG 61
gi 23615236    8 VKTEACSFSEYRIYPGRGQKYIAR----DGKVYFYLSSKFASLALQKKKAAKLRWTQT 61
gi 85000097    8 IKTEHCNFTDYRVYPGRGKKFVAR----DGKVYFFINGKSAAFHKRKVKPAKLKWNLA 61
gi 50787734    3 TKTELCHFSEYKVYPGRGHRFVRK----DGRTFFFLSRKTRSLHFQKVKTSDLTWTPM 56
gi 145502933   3 IKTDLCSFSEWRIYPGHGRRFVAK----DGRLFYYLNQKSRAFSARKIKSQEIQWTVA 56
gi 89299139    3 VRTGTCSFCEYRIYPGRGQRFIAK----DGRGFFFLTKKAKCLSLRKVKAQKITWTIA 56
gi 3445524     1 MRTIDCEFSHFAVHPGHGRRYVPFaflsTKPVLTFARPKCFAMYMRKKNPRFIAWTRT 58
gi 123380722   3 TKTEICGFSGHIFHAGHGRVHIRE----DKHLMAFESRKAFRMWERKRNPRKIAWTEH 56
gi 19074515   14 MIQGVSMFSGRNIPKGSGIYEVMS----DGRAVLTASNKERRLIARKINPRDIRWTTS 67

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