1BJO,1BT4


Conserved Protein Domain Family
PSAT_like

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cd00611: PSAT_like 
Click on image for an interactive view with Cn3D
Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as a dimer and catalyzes the conversion of phosphohydroxypyruvate to phosphoserine.
Statistics
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PSSM-Id: 99736
View PSSM: cd00611
Aligned: 15 rows
Threshold Bit Score: 549.974
Threshold Setting Gi: 1711380
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1BT4; catalytic residue (lys) and cofactor (PLP)
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1BJO_A        3 FNFSSGPAMLPAEVLKQAQQELRDWnglgtSVMEVSHRGKEFIQVAEEAEKDFRDLLnvpsnYKVLFCHGGGRGQFAAVP 82
1BT4_A        6 YNFNAGPAALPLEVLERAQAEFVDYqhtgmSIMEMSHRGAVYEAVHNEAQARLLALLgnptgYKVLFIQGGASTQFAMIP 85
gi 1711380    8 VNFAAGPAAMITSVVEEFGKDFVNFqglgmGVAEISHRSKQGSGIVTSAESNFRKLYnipenFHILFMQGGGTEQFAACL 87
gi 16078066   5 TNFNAGPAALPLEVLQKAQKEFIDFnesgmSVMELSHRSKEYEAVHQKAKSLLIELMgipedYDILFLQGGASLQFSMLP 84
gi 15791694   4 INFSAGPSTLPLEILEQAQKELCDYqgrgySIMEISHRTKVFEEVHFGAQEKAKKLYelnddYEVLFLQGGASLQFAMIP 83
gi 29346563   4 HNFNAGPSILPREVIEDTAKAILDFngsglSLMEISHRAKDFQPVVDEAEALFKELLnipegYSVLFLGGGASMEFCMVP 83
gi 119522     8 VNFGPGPAKLPHSVLLEIQKELLDYkglgiSVLEMSHRSSDFAKIVNNTENLVRELLavpdnYKVIFLQGGGCGQFSAVP 87
gi 464758     9 QHFGAGPAQMPTPVLQQAAKDLINFndiglGIGEISHRSKDATKVIEDSKKHLIELLnipdtHEVFYLQGGGTTGFSSVA 88
gi 27881918   7 VNFGAGPAKLPQSVLLQAQKELLDYsgtgiSILEMSHRSSDFTKIINTTENLIRELLnvpenYKILFLQGGGSGQFSAVP 86
gi 8928355    3 INFAAGPAKLPEEVLKEVQENLVNCngsgiSVMEMSHRSSNYAKIHDATISDLRELLnvpsnYKILLMQGGGTGQFAAVA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1BJO_A       83 LNIlgd---------ktTADYVDAGYWAASAIKEAKKY---CTPNVFdakvtv-dglraVKPMREWqls---dnAAYMHY 146
1BT4_A       86 MNFlke---------gqTANYVMTGSWASKALKEAKLI---GDTHVAassea--snymtLPKLQEIqlq---dnAAYLHL 148
gi 1711380   88 YNVyahhalkngnakslVANYIITGAWSKKAYAEAERLg-fPCHVAVdmkela-gkygsLPEDKDLkftp-dgeTSLVYY 164
gi 16078066  85 MNFltp---------ekTAHFVMTGAWSEKALAETKLF---GNTSITatset--dnysyIPEVDLTdv----kdGAYLHI 146
gi 15791694  84 MNLal----------ngVCEYANTGVWTKKAIKEAQILg--VNVKTVassee--snfdhIPRVEFSd------nADYAYI 143
gi 29346563  84 FNFle-----------kKAAYLNTGVWAKKAMKEAKGFg--EVVEVAssaea---tytyIPKDYTIpa-----dADYFHI 142
gi 119522    88 LNLiglk-------pgrCADYVVTGAWSAKAAEEAKKF---GTVNIVhpklg---sytkIPDPSTWnln---pdASYVYY 151
gi 464758    89 TNLaaayvg--khgkiaPAGYLVTGSWSQKSFEEAKRLh-vPAEVIFnakdynngkfgkIPDESLWedkikgkaFSYVYL 165
gi 27881918  87 LNLiglk-------eerCADYLVTGTWSARAAKEAEKY---GKVNVIhpkld---sytkIPDSSTWsln---psASYVYY 150
gi 8928355   83 LNLigk---------tgTADYVITGSWSAKAAKEAAQYgtvNAVLPKlak------yttVPRQETWkld---pnASYVYY 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                           #                           
1BJO_A      147 CPNETIDGIAIDETPdfg---adVVVAADFSSTILSRPIDVSRYGVIYAGAQKNIgpAGLTIVIVREDllgkan------ 217
1BT4_A      149 TSNETIEGAQFKAFPdt----gsVPLIGDMSSDILSRPFDLNQFGLVYAGAQKNLgpSGVTVVIVREDlvaesp------ 218
gi 1711380  165 CDNETVHGVEFNEPPtni--pkgAIRVCDVSSNFISRKIDFTKHDIIFAGAQKNAgpAGITVVFVRDSvlarptpael-- 240
gi 16078066 147 TSNNTIFGTQWQEFPns-----pIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLgpSGVTVVIMKKSwlqnen------ 215
gi 15791694 144 CSNNTIYGTQYQNYPkt-----kTPLIVDASSDFFSRKVDFSNIALFYGGVQKNAgiSGLSCIFIRKDmlersk------ 212
gi 29346563 143 TTNNTIYGTELKEDLns-----pVPMVADMSSDIFSRPIDVSKYICIYGGAQKNLapAGVTFVIVKNDavgkvs------ 211
gi 119522   152 CANETVHGVEFDFVPdv----kgAILVCDMSSNFLSRPVDVSKFGVIFAGAQKNVgaAGVTVVIVRDDllgfal------ 221
gi 464758   166 CENETVHGVEWPELPkclvndpnIEIVADLSSDILSRKIDVSQYGVIMAGAQKNIglAGLTLYIIKKSilknisgasdet 245
gi 27881918 151 CCNETVHGVEFNFIPdt----kgVILVSDMSSNFLSRPVDVSKFGLIFAGAQKNVgcAGVTVVIVREDligkal------ 220
gi 8928355  145 CDNETVEGVEFDFVPevp---agVPLVADMSSNFLSRPFDVSKFGVIYAGAQKNIgpAGTTVIIVRDDligkhl------ 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1BJO_A      218 ------iacpsILDYSILNDNGsmfNTPPTFAWYLSGLVFKWLKAnGGVAEMDKINQQKAELLYGVIDNs-dFYRNdvak 290
1BT4_A      219 ------khlptMLRYDTYVKNNslyNTPPSFGIYMVNEVLKWIEErGGLEGVQQANRKKASLIYDAIDQsggFYRGcvdv 292
gi 1711380  241 -hklnipvsptVSDYKIMADNHslyNTLPVATLHAINLGLEYMLEhGGLVALEASSIEKSKLLYDTLDKh-dLYISvvep 318
gi 16078066 216 ------anvpkILKYSTHVKADslyNTPPTFAIYMLSLVLEWLKEnGGVEAVEQRNEQKAQVLYSCIDEsngFYKGhark 289
gi 15791694 213 -----nkqipsMLNYLTHAENQslfNTPPTFAIYMFNLEMDWLLNqGGLDKVHEKNSQKATMLYECIDLsngFYKGhadk 287
gi 29346563 212 ------ryipsMLNYQTHIDNGsmfNTPPVVPIYAALLNLRWIKAqGGVKEMERRAIEKADMLYAEIDRn-kLFVGtaak 284
gi 119522   222 ------recpsVLEYKVQATSSslyNTPPCFSIYVMGLVLEWIKNnGGAAAMKKLSTIKSQMIYEIIDNsqgFYVCpvep 295
gi 464758   246 lhelgvpitpiAFDYPTVVKNNsayNTIPIFTLHVMDLVFQHILKkGGVEAQQAENEEKAKILYEALDAnsdFYNVpvdp 325
gi 27881918 221 ------kecpiILDYQVQAGNNslyNTPPCFSIYIMGLVLEWIRNnGGADAMERLNKQKSALVYDIINRsngFYSCpvda 294
gi 8928355  216 ------kitpsILNFEQMDKNNsllNTPPTFGIYVMGLVFKWIKRnGGVAGMAKLAAAKSKLIYDTINQsngFYYCpvdv 289
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                                                                              
1BJO_A      291 rnRSRMNVPFQlads----aldKLFLEESFaaglhALKGHrvvgGMRASIYNamPLEGVKALTDFMVEFER 357
1BT4_A      293 dsRSDMNITFRlase----eleKEFVKASEqegfvGLKGHrsvgGLRASIYNavPYESCEALVQFMEHFKR 359
gi 1711380  319 aaRSRMNVTFRiepq----eleSEFLAEAEkhhlvQLKGYrsvgGIRASLYNaiSVEQTRRLIDLLESFAK 385
gi 16078066 290 dsRSRMNVTFTlrdd----eltKTFVQKAKdakmiGLGGHrsvgGCRASIYNavSLEDCEKLAAFMKKFQQ 356
gi 15791694 288 kdRSLMNVSFNiakn---kdlePLFVKEAEeagmiGLKGHrilgGIRASIYNalNLDQVKTLCEFMKEFQG 355
gi 29346563 285 edRSRMNICFVmapey--kdleADFMKFATekgmvGIKGHrsvgGFRASCYNalPKESVQALIDCMQEFEK 353
gi 119522   296 rnRSMMNIPFRignakgdealeKRFLDKALelhmiSLKGHrsvgGVRVSLYNavTIEDVQKLASFMKNFLE 366
gi 464758   326 kcRSKMNVVFTlkkd----gldDQFLKEAAarhltGLKGHrsvgGFRASIYNalSVKAVQNLVDFIKEFAE 392
gi 27881918 295 acRSRMNIPFRigkkegdesleKSFLDGASklgmiSLKGHrsvgGIRASLYNavTVEDVKILAAYMEDFLR 365
gi 8928355  290 nvRSRMNVPFRigsasgddaleKEFLSKAEaegmiQLKGHrsvgGIRASLYNavTLAETQQLANLMLAFYK 360

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