Conserved Protein Domain Family
Orn_deC_like

?
cd00615: Orn_deC_like 
Click on image for an interactive view with Cn3D
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.
Statistics
?
PSSM-Id: 99739
View PSSM: cd00615
Aligned: 21 rows
Threshold Bit Score: 342.691
Threshold Setting Gi: 27469220
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1ORD; catalytic residue and cofactor (PLP)
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1ORD_A      109 PFFKSLKEYVSrgliqFDCPGHQGGQyyrkhpagrefydfFGETVFRADLCnaDVALGDLLIHEGPAVAAEKHAARvynA 188
gi 18309531  10 PIYEALKWYKNqrivpFDVPGHKQGRgnte------lrefLGEDCVSVDVNs-MKPLDNLCHPTSVIKDAEELAAEa-fG 81
gi 118334     7 PLYTGLKKHASrqpvqFHIPGHKKGAgmdpe-----frqfIGENALSIDLIn-IEPLDDLHAPKGIIKQAQDLAAEa-fG 79
gi 586866     4 PLYKALIQHARrnshsFHVPGHHNGDvffd------daksIFDPLLTIDVTe-LAGLDDLHHPSGVIKEAQELASQl-yG 75
gi 15612604   8 PLFERLVQHDRggpisCHVPGHKQGAlfhk------dacsYFQSILSLDVTe-LTGLDDLHDPRGVIAEAQALTARy-vG 79
gi 15895605  10 PLFNALMEYVNrdtipFHVPGHKKGNgidke-----fknfIGENPFKIDVTv-FKLVDSLHHPTGPIKKAQELAADa-yG 82
gi 15900796  10 PIYEALVKLRKkrivpFDVPGHKRGRgnpe------lvelLGEKCVGIDVNs-MKPLDNLGHPISIIRDAEELAADa-fG 81
gi 27469220   4 PIIQKLNHLIEkkaisMHVPGHKNMTig-----------yLNRLDLAMDMTe-ITGLDDMHYPEGIILESMENFRKh--K 69
gi 28209986   5 PLVEGVLNYIKkkniyFSMPGHKQGEgflst----digkeIKEQILKLDITe-VNGVDNLHNPTGIIKESQIKLSEl-yG 78
gi 29244683  37 PLIQALKSTANqdvscFHFPGHNRGKaspps-----lselIGSRTFLHDLPe-LPELDDLFSPKGVILDAQKRAAEl-fG 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1ORD_A      189 DKTYFV-LGGSSNANNTVTSALvSNGDLVLFDRNNHKSVYNSALAMaggRPVYLQTNRNPy-GFIGGIYDSDFDEkkire 266
gi 18309531  82 ADKAFFmVNGTTSAVQAMIMSVcKDGDKIIMPRNVHRSAINSLIITg-vTPVYINPGIHGrlGISLGMAMEDIKKaike- 159
gi 118334    80 ADHTFFsVQGTSGAIMTMVMAVcGPGDKIIIPRNVHKSIMTAIVFSg-aVPIFIHPEIDNelGISHGITLESAKRalte- 157
gi 586866    76 SAESFFlVNGTTVGNLAMILSVcEPGDTILVQRNCHKSVFHAVDLSg-aEPVYLAPDVDSamHVPTHVPLGTIKEalea- 153
gi 15612604  80 AEATCFlVNGSTVGNLAMILGTlEPGDTVFVQRDSHKSVMNGLAMAr-vHPIFLSPSYDErtQLPTGITEQTLKQalie- 157
gi 15895605  83 SKAAFYsVNGTSGAIQGMILSVvGDGDKIIVPRNVHKSVTAGIILSg-aVPVYMHPEVDRrvGIAHGVSPETVGEtlkn- 160
gi 15900796  82 ASHAFLmIGGTTSSVQTMILATcKAGDKIILPRNVHKSAINALVLCg-aIPIYIEMSVDPkiGIALGLENDRVAQaikd- 159
gi 27469220  70 NYDAFLlVNGTTSGILSVIQAFsTRKGKYLISRNVHKSVFHGLDITq-qQATITKTDVSK--KTNQYVNPKINQDkn--- 143
gi 28209986  79 SKKSYFlVNGSSSGNMIMIFSSfEEGDKIIIDRNCHKSIFNTIIIRk-lKAIYVKNKIHKgfNLPLSVDSSHIIKtike- 156
gi 29244683 110 SFKTWFlVNGSTCGIQASVMATcSPGDYLIIPRNCHISVISALVLSg-aVPKYIVPEYNSgwDIAGGITPSQVDKvvkel 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1ORD_A      267 laakvdperakwkrpFRLAVIQLGTYDGTIYNAHEVVKRIghlcDYIEFDSAWVGYEqFIPMMRNSSplliddlgpedpg 346
gi 18309531 160 ------------npdAKAIFVNNPTYYGICSNLREIVKLAhennMYVLVDEAHGTHFyFDKRLPVSAmea--------ga 219
gi 118334   158 ------------hpdAKGLLVINPTYFGVAADLKSIVELAhsfdVPVLVDEAHGVHIhFHDELPLSAmqa--------ga 217
gi 586866   154 ------------ypdAKGLVLTNPTYYGHSADLTEIITEAhhygIPVLVDEAHGAHFiLGEPFPVSAlkm--------ga 213
gi 15612604 158 ------------hpnGKALILTYPSYYGVARSIRPLVQMAkeagLYVLVDEAHGAHFpVGDPFPKQAleq--------ga 217
gi 15895605 161 ------------npdAKAVLLINPTYYGVSTDIKKIADIVhsydIPLIVDEAHGPHLsFNDRLPVSAlka--------ga 220
gi 15900796 160 ------------hpdAKAILINNPTYYGICSDLKGLTEMAheagMMVLVDEAHGAHLhFTDKLPISAmda--------ga 219
gi 27469220 144 -------------qyYKLAICTYPNYYGETFDISQYIKQLhhrgIPILVDEAHGAHFgLDGFPESSMnf---------na 201
gi 28209986 157 ------------nkdAKGIIITYPNYYGICCDLEKIIIEAkkhnMKVLIDCAHGAHFvANEKLPKNPvkl--------ga 216
gi 29244683 189 e---------edrkkVGAVLVTSPTYHGICSNIQGIVNVChlqgIPVIVDEAHGAHFrFHRNFPSSAteq--------ga 251
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #                                                                       
1ORD_A      347 IIVVQSVHKQQAGFSQTSQIHKKdshikgqlrycDHKHFNNSFNLFMSTSPFYPMYAALDVNAamqe---geaGRKLWHD 423
gi 18309531 220 DMAAVSIHKTGGSLTQSSMLLMKcn-------riKPDYVRTIINLTQTTSGSYLLLSSLDIARrnl----alnGEKIFEE 288
gi 118334   218 DIAATSVHKLGGSLTQSSILNMReg-------lvSKDRVQSILSMLTTTSTSYLLLASLDVARkrl----ateGRQLAEE 286
gi 586866   214 DIVVQSAHKTLPAMTMGSYLHLNssc------riNRDRVAEYLNRLQSSSPSYPIMASLDIARayvq---hiiEEQKLSD 284
gi 15612604 218 DVVVQSAHKTLPALTMGSYLHFAhgl-----hskIKDSIREQLQILQSSSPSYPILASLDAARgf------leDLTNVKD 286
gi 15895605 221 DMCAQSTHKIIGALTQMSLLHVNsd-------riDMNRVQQIMNLLQTTSPSYILMASMDCARrqi----alhGKELLDG 289
gi 15900796 220 DMAAVSMHKSGGSLTQSSILLIGeq--------mNSEYVRQIINLTQSTSASYLLMASLDISRrnl----alrGKESFEK 287
gi 27469220 202 DYVVQSYHKTLPALTMGSVIYIHkd-------apLRQQVIDYLTYFQTSSPSYLIMSSLELANkfykeydstlFDQRRKM 274
gi 28209986 217 DMVVMSSHKTLPSLTQTAFLHVNne--------eLIDKVDFYFDTFISTSPSYLFLVSMDYSRyyl----eeyGEETYEK 284
gi 29244683 252 DLVVQSTHKVLCSLTQSSMLHMAgd-------lvDADKVSQCLQLLQSSSPSYLLLSSLDAARaqlse-naesFDEPVSM 323
                       330
                ....*....|....
Feature 1                     
1ORD_A      424 LLITTIEARKKLIK 437
gi 18309531 289 VVGIAEYAREEINK 302
gi 118334   287 TLKLANQTRDRLNQ 300
gi 586866   285 ILQRIETLKQTFDS 298
gi 15612604 287 TLDSIAEMNRRIEQ 300
gi 15895605 290 TIDLCNYARREINK 303
gi 15900796 288 VIELSEYARREINA 301
gi 27469220 275 LIDLLVNMGFTVIE 288
gi 28209986 285 LIKLLKIYKQKINS 298
gi 29244683 324 ALETKHQLRIIPGI 337

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap