1FRW,2DPW,1QWJ,1VH3,1YP4,1TZF,1JYL,2CU2,2PA4,1LVW,1H5R,1G97,1VPA,1K4V,1GA8,1FGG,1JV1,2ICY,1FO8,1LL2,1FR8,1XHB,3CKJ,2Z86,2Z87,1H7Q


Conserved Protein Domain Family
Glyco_tranf_GTA_type

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cd00761: Glyco_tranf_GTA_type 
Click on image for an interactive view with Cn3D
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold.
Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.
Statistics
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PSSM-Id: 132997
View PSSM: cd00761
Aligned: 289 rows
Threshold Bit Score: 30.9374
Threshold Setting Gi: 13096713
Created: 7-Oct-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           # #                                                 #                        
1FRW_A         9 GVVLAGgkarrmggvdkgllelngkpLWQHVADALMtq-----------lsHVVVNANrhqeiyqasglkv--------- 68
gi 50955623   45 FFVPCRde----------------aaVIERTVAAARrdf---------pavHVWVVDDhsdddtgriveaiarrds---- 95
gi 115423691 159 VYVPTYnep---------------ldVVRQTVLAAQaldwp------adrlNVYVLDDgrrpefqafceqig-------- 209
gi 63255287  397 LHVPCYnep---------------pdMVKRTLDSLQtldy--------pdfEVLVIDNntqdpaiwkpierycqql---- 449
gi 85717071   51 VIVPAHde----------------sgGIIPTISDIKsqls--------sndRLIVVADnctddtaavaesaga------- 99
3CKJ_A        52 VVLPALde----------------edTIGSVIDSISplvd-------glvdELIVLDSgstddteiravaagarv----- 103
gi 20137697   29 VLLPTYne----------------reNLPLIVWLLVksfse-----sginyEIIIIDDgspdgtrdvaeqlekiy----- 82
gi 156401039  47 VVVPSYne----------------eeRLPIMMDETLeyllekkksnpsftsEIIVVDDgskdkttevglryakqc----- 105
gi 37523798   42 VQLPVFne----------------lyVCRRLLAATCaldyp------realHIQVLDDstdetvqllaaaieeqrr---- 95
gi 91787013  162 IIMPICned---------------vrTVFAGLRATCesvamt---ghvknfDVFVLSDsshpaiiraeraawedlrsqla 223
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                           # #                          
1FRW_A        69 -----------iedsladypgplAGMLSVmqqe----------agewFLFCPCDTpyippdlaa-------rlnhqrkda 120
gi 50955623   96 ------rvhlvtrrrpeartgkgDALNAAydalnaflpadadreriiVMVLDADGelsaralamma---saevfldpgvg 166
gi 115423691 210 ---------igyltrsdnkhakaGNINAAlart----------qgeyVAIFDCDHvpvrsflqic-----mgwflkdpkl 265
gi 63255287  450 ------gprfrffhvsplpgfkaGALNYLlrhta--------edaevVAVIDADYcvhrqwlkhm------vphftdpkv 509
gi 85717071  100 ---------eviarndlekigkgYALGWGishlrk-------dppdfVVVFDADCriqsdalerlt----dicgklqrpv 159
3CKJ_A       104 ------vsreqalpevpirpgkgEALWRSlaas----------rgdiVVFVDSDLinphpmfvpwl----vgplltgdgv 163
gi 20137697   83 ------gsdrillrprekklglgTAYIHGmkha----------tgnyIIIMDADLshhpkfipef------irkqkegnf 140
gi 156401039 106 ------gvssvrvltlaknrgkgGAVRMGvfss----------rgrkILMADADGatkfsdldrldtalndvtaakgvkp 169
gi 37523798   96 -----lgfsiehlhrkerhgfkaGALAAAtpla----------ngeyIAIFDADFlpppdwlkra-----lvhfadgrvg 155
gi 91787013  224 shpeqpqievyyrlrkrrtdrkaGNVADFcrrwg--------kdyryMVVLDADSvmsgdclvamv----klmeanpkag 291
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1FRW_A       121 PVVWVHdger---------------------------------------dhpTIALVNraiepllleylqag-----err 156
gi 50955623  167 GAQVVVwmknrherrpkpgh------------------gwlgnlfgrflvklQDIEFRtiiaamqslrar---------t 219
gi 115423691 266 AMLQTPhvffspdpfer------------------------nlgtfrnvpneGELFYGvvqdgndlwn------------ 309
gi 63255287  510 AVIQSPqdyrdgh--------------------------------eslfkccCQAEYRgffnigmvirnd---------h 548
gi 85717071  160 QACFLMrspdnspi-------------------------------dhrfaefAFLLRNwirpfglsnln----------- 197
3CKJ_A       164 HLVKSFyrrplnvgdagggagatgggrvtelvarpllaalrpelgcilqplgGEYAATrelltsvpfapgygveigllvd 243
gi 20137697  141 DIVSGTrykgnggvygwdlkrkii----------srganfltqillrpgasdLTGSFRlyrkevlekliek------cvs 204
gi 156401039 170 AIVCGSrahlqeeavatrsafrnfl---------mygfhflvwflcvkgikdTQCGFKlftrsaalltfsa------lhv 234
gi 37523798  156 LVQTRWghtnpgy---------------------------------slltrlQALGIDghfaveqqarca--------ng 194
gi 91787013  292 IIQTATqaighv----------------------------------tlharaQQFASRvtgrlftlgmqfw-------qm 330
                        250
                 ....*....|...
Feature 1                     
1FRW_A       157 vmvfmrlaggHAV 169
gi 50955623  220 gtvglggngqFAR 232
gi 115423691 310 -atffcgscaVIR 321
gi 63255287  549 daiiqhgtmtLIR 561
gi 85717071  198 cpvqlmgtgmIFP 210
3CKJ_A       244 tfdrlgldaiAQV 256
gi 20137697  205 kgyvfqmemiVRA 217
gi 156401039 235 erwafdvellYIA 247
gi 37523798  195 yyfnfngtagVWR 207
gi 91787013  331 geshywghnaIIR 343

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