Conserved Protein Domain Family
PI3Kc_C2_beta

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cd00895: PI3Kc_C2_beta 
Catalytic domain of Class II Phosphoinositide 3-kinase beta
PI3Ks catalyze the transfer of the gamma-phosphoryl group from ATP to the 3-hydroxyl of the inositol ring of D-myo-phosphatidylinositol (PtdIns) or its derivatives. The class II beta isoform, PI3K-C2beta, contributes to the migration and survival of cancer cells. It regulates Rac activity and impacts membrane ruffling, cell motility, and cadherin-mediated cell-cell adhesion. PI3Ks play an important role in a variety of fundamental cellular processes, including cell motility, the Ras pathway, vesicle trafficking and secretion, immune cell activation and apoptosis. They can be divided into three main classes (I, II, and III), defined by their substrate specificity, regulation, and domain structure. Class II PI3Ks preferentially use PtdIns as a substrate to produce PtdIns(3)P, but can also phosphorylate PtdIns(4)P. They function as monomers and do not associate with any regulatory subunits. Class II enzymes contain an N-terminal Ras binding domain, a lipid binding C2 domain, a PI3K homology domain of unknown function, an ATP-binding cataytic domain, a Phox homology (PX) domain, and a second C2 domain at the C-terminus. The PI3K catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Statistics
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PSSM-Id: 119421
View PSSM: cd00895
Aligned: 3 rows
Threshold Bit Score: 704.453
Threshold Setting Gi: 363743041
Created: 8-Dec-2000
Updated: 2-Mar-2014
Structure
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Aligned Rows:
 
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                               # ### #   
gi 73920246   987 REEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFAlNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKL 1066
gi 363743041  981 REEFDRQCLLVNTLARLAQQVRDAAPSARQGILREGLEEVKQFFKaNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKL 1060
gi 326671837  934 REEFDRQCWLVNVLAKVAQRVREASPSSRQAILREGLDDVKQFFSiNSSCRLPLNPGLLVKGINIQSCSYFNSNAVPLKL 1013
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       # #  #                              #           ####    #  #      
gi 73920246  1067 SFQNvdplgenIRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHG 1146
gi 363743041 1061 SFQNvdplgenIRVIFKCGDDLRQDMLTLQMIRIMNKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHG 1140
gi 326671837 1014 SFQNqdhlgdnINVIFKAGDDLRQDMLTLQIIRIMNKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPSAETLRKIQVEHG 1093
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              # #         ##             
gi 73920246  1147 VTGSFKDRPLADWLQKHNPgedeYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGN 1226
gi 363743041 1141 VTGSFKDRPLADWLQKHNPeedeYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGN 1220
gi 326671837 1094 VTGSFKDRPLADWLQKHNPteeeYEKAVENFIYSCAGCCVATYILGICDRHNDNIMLKTSGHMFHIDFGKFLGHAQMFGN 1173
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 73920246  1227 IKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELsdLEDLKYVYDALRPq 1306
gi 363743041 1221 IKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELsdLEDLKYVYDALRPq 1300
gi 326671837 1174 IKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCEAYNRIRKHAHLFLNLLGLMLSSGIPELsdVDDLKYVYDALRPh 1253
                         330       340       350
                  ....*....|....*....|....*....|....
Feature 1                                           
gi 73920246  1307 dtEANATTYFTRLIESSLGSvATKLNFFIHNLAQ 1340
gi 363743041 1301 dtDADATTYFTRLIESSLGSvATKLNFFIHNLAQ 1334
gi 326671837 1254 esEADATMHFTRLIESSLGSvATKLNFFIHNLAQ 1287

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