1SZP,5H1B,1N0W,1PZN,2ZJB,5H1B


Conserved Protein Domain Family
Rad51_DMC1_archRadA
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cd01123: Rad51_DMC1_archRadA 
recombinase Rad51, DMC1, and archaeal RadA
This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal protein RadA. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similar recombination reaction as RecA, using ATP-dependent DNA binding activity and a DNA-dependent ATPase. However, this reaction is less efficient and requires accessory proteins such as RAD55/57 .
Links
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Statistics
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PSSM-Id: 410868
Aligned: 6 rows
Threshold Bit Score: 420.013
Created: 7-Mar-2002
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:contains the Walker A and Walker B motifs
  • Structure:5H1B; Homo sapiens RAD51 with bound ATP homolog, contacts at 4A
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                #######                           #      #           
1SZP_A     81 LTTGSKNLDTLLGGGVETGSITELFGEFRTGKSQLCHTLAVTCQipldigggegKCLYIDTEGTFRPVRLVSIAQrfgld 160 baker's yeast
5H1B_A    102 ITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQlpidrgggegKAMYIDTEGTFRPERLLAVAErygls 181 human
1N0W_A      6 ITTGSKELDKLLQGGIETGSITEXFGEFRTGKTQICHTLAVTCQlpidrgggegKAXYIDTEGTFRPERLLAVAErygls 85  human
1PZN_A    113 ISTGSKSLDKLLGGGIETQAITEVFGEFGSGKTQLAHTLAVXVQlppeegglngSVIWIDTENTFRPERIREIAQnrgld 192 Pyrococcus furiosus
2ZJB_A    104 ITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLCVTAQlpgaggypggKIIFIDTENTFRPDRLRDIADrfnvd 183 human
5H1B_B    102 ITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQlpidrgggegKAMYIDTEGTFRPERLLAVAErygls 181 human

Feature 1                                                                                     
1SZP_A    161 pdDALNNVAYARAYnaDHQLRLLDAAAQMMSes-----rfSLIVVDSVMALYRtdfsGRGELSARQMHLAKFMRALQRLA 235 baker's yeast
5H1B_A    182 gsDVLDNVAYARAFntDHQTQLLYQASAMMVes-----ryALLIVDSATALYRtdysGRGELSARQMHLARFLRMLLRLA 256 human
1N0W_A     86 gsDVLDNVAYARAFntDHQTQLLYQASAXXVes-----ryALLIVDSATALYRtdysGRGELSARQXHLARFLRXLLRLA 160 human
1PZN_A    193 pdEVLKHIYVARAFnsNHQXLLVQQAEDKIKellntdrpvKLLIVDSLTSHFRseyiGRGALAERQQKLAKHLADLHRLA 272 Pyrococcus furiosus
2ZJB_A    184 hdAVLDNVLYARAYtsEHQVELLDYVAAKFHeea---gifKLLIIDSIMALFRvdfsGRGELAERQQKLAQMLSRLQKIS 260 human
5H1B_B    182 gsDVLDNVAYARAFntDHQTQLLYQASAMMVes-----ryALLIVDSATALYRtdysGRGELSARQMHLARFLRMLLRLA 256 human

Feature 1                                                          #                  ###    
1SZP_A    236 DQFgVAVVVTNQVvaqvdggmafnpdpkKPTGGNIMAHSSTTRLGFKKGkgCQRLCKVVDSPCLpeAECVFAIYEDGVG 314 baker's yeast
5H1B_A    257 DEFgVAVVITNQVvaqvdgaamfaadpkKPIGGNIIAHASTTRLYLRKGrgETRICQIYDSPCLpeAEAMFAINADGVG 335 human
1N0W_A    161 DEFgVAVVITNQVvaqvdgaaxfaadpkKPIGGNIIAHASTTRLYLRKGrgETRICKIYDSPCLpeAEAXFAINADGVG 239 human
1PZN_A    273 NLYdIAVFVTNQVqarpda---ffgdptRPIGGHILAHSATLRVYLRKGkgGKRIARLIDAPHLpeGEAVFSITEKGIE 348 Pyrococcus furiosus
2ZJB_A    261 EEYnVAVFVTNQMtadpgatmtfqadpkKPIGGHILAHASTTRISLRKGrgELRIAKIYDSPEMpeNEATFAITAGGIG 339 human
5H1B_B    257 DEFgVAVVITNQVvaqvdgaamfaadpkKPIGGNIIAHASTTRLYLRKGrgETRICQIYDSPCLpeAEAMFAINADGVG 335 human

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