1OBG


Conserved Protein Domain Family
SAICAR_synt_Sc

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cd01414: SAICAR_synt_Sc 
Click on image for an interactive view with Cn3D
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.
Statistics
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PSSM-Id: 133469
View PSSM: cd01414
Aligned: 89 rows
Threshold Bit Score: 209.327
Threshold Setting Gi: 42524403
Created: 30-Apr-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 32 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:by similarity to other members of this superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          # #### #                         #           #                                
1OBG_A        13 LVARGKVRDIYEVDa------------------gTLLFVATDRISAYDVIMENs-----iPEKGILLTKLSEFWFKFLSn 69
gi 9664578     4 MLYQGKVKQVWSTDdp-----------------dILEFRFTNQISVFDQIIPSl-----iPRKGESLNRTTAHWFKLVEq 61
gi 22001871    3 IIAKGKVKDVYDDGd-------------------TLVFRFSNRISVFDKIIPTe-----iENKGESLCRTSSFWFRYIGe 58
gi 22001872    9 GMASVKDRRVESPAtdt--------------dlgRGVFEFSDRYSVFDWGEMPdh----vPGKGASLCTMGAYTFEQLAa 70
gi 197624536   3 LIRKGKVKEVYALNd------------------kELLFLFTDNISVFDKIIPSk-----iPRKGETLCKSAAFWFEKIGe 59
gi 48478425    3 FVSSGKVKDIYNDNg-------------------NLVFKFSNRISVFDKIIPSe-----iPYKGEVLCRTAYYWYRLCEd 58
gi 219676374  20 PVHSGKVRSVYFLRpedsrrliqergypvaphsdLAVMVISDRLSAFDCLWHSesl-agvPGKGAALNAIAAHWFESFGq 98
gi 116754803  10 LLMRGKVKEAYDLGs-------------------ELEFQFTDNISVFDKIIPTr-----iPYKGETLCREGVFWFERAEr 65
gi 219678823  21 PVHSGKVRSAYWLTsndsrrlveargypasadsqLGILIISDRISAFECLWHGegdlrgvPGKGAALNAISAHWFDRFRt 100
gi 110669014   2 TSVKEFLIETEPTTtg----------------ygRGRFVFTDQYSVFDWGAMPdq----iPHKGTSLCTMGAYNFELLEe 61
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                     #                                                  
1OBG_A        70 ------------------------dVRNHLVdiapgktifdylp-----------------------------------a 90
gi 9664578    62 e----------------------gvCGTHLVelnapdrclv--------------------------------------- 80
gi 22001871   59 r-----------------------gIKNHFIemidnrtm----------------------------------------- 74
gi 22001872   71 agvpthyqgvrtpdgetvrladapeAPTQMVidltqvptlp--------------------------------------- 111
gi 197624536  60 m-----------------------kIKNHYLscedskmr----------------------------------------- 75
gi 48478425   59 l-----------------------nIKTDLIglksnnem----------------------------------------- 74
gi 219676374  99 a----------------------qlAPHHLLem----------------------------------------------- 109
gi 116754803  66 m-----------------------gIRNHFVrylppagmi---------------------------------------- 82
gi 219678823 101 e----------------------glARSHILev----------------------------------------------- 111
gi 110669014  62 n-----------------------gISTHYIgvvrpskaetttidnqssdesdhittdpcsldacstaptemaikltqvp 118
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         #### #   # # #   ###                                    # #    
1OBG_A        91 klsepkyktqleDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTGtv-hgLKQPQGLKE--SQEFPEPIFTPSTKAEqg 167
gi 9664578    81 ---rkvevvkepGAIPRDAEWVFVPLEFIVRHYLSGSAWRRFQRGEltaesLGVSQDAEY--GVKLSEPFVEVTTKFEa- 154
gi 22001871   75 ----rvrkydvpEKVSPGSSGYVIPLEFITRHYVAGSLYDRLKAGStkpadIGLNHFPDY--GEKLPSPVFEVTTKREk- 147
gi 22001872  112 ---fedgsydydRYHDAGGSNYLVPLEVVFRNAVPVGSSLRTRCAPad-vgIDADEWPQG--PVELPETIVEFSTKYEe- 184
gi 197624536  76 -----vgrfriiNKPRIENENYLIPLEFITRYYVAGSLYERLKNGKmdyklLGFESMPEY--GEKLPEPYFEITTKFEa- 147
gi 48478425   75 ----vvkrydvvNKGFNFKINYMIPIEFITRYYVAGSLYDRIKSKKidyhdLGFKNEPEY--GEKLPDPFFEMTTKREk- 147
gi 219676374 110 ----------phPMVWIVRQAKPLMIEAIARRYLTGSLWRAYAQGErviggVTLPDGLKQ--YQRFSELLFTPSTKGVvr 177
gi 116754803  83 ---vrkvsivspERITRETKGHLIPLEFICRWYVAGSLFDRIESGEiepeaLGFPRGRKVsfAEQLPEPYIELSTKLEk- 158
gi 219678823 112 ----------phPLVWVVQRAQPIQIEAIARRYITGSMWRAYHAGArdfcgYTLPPGLRA--HERLEELVVTPSTKGIir 179
gi 110669014 119 alpyddgaydyeSYHEAGGQNYLIPLEVVFRNSVPIGSSLRDRKSPqe-ydIDADAWPSN--PVELPKPVIEFSTKYEe- 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #                                                    ### #             
1OBG_A       168 -------eHDENISp---AQAAEl------VGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDek---tnEI 228
gi 9664578   155 --------FDRNIDr---EEALQis----nITDQEFDSIVQAALKVDEIIEREAAKNGLIHVDGKKEFALGpg----rKV 215
gi 22001871  148 --------TDRLLDi---DEALEis----gLTREEYAEIRETILKIDEMMEQEVGKRGLIHADGKKEVALGke----rEP 208
gi 22001872  185 --------QDRYLSr---SMADEi------AGDADIAELDALARRVNETITDCAADAGFVHDDGKLECVYVd-----gEV 242
gi 197624536 148 --------YDRKVSf---EEAREig----gLRQSEIEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFGeg----rEI 208
gi 48478425  148 --------TDRVLNt---DEAMSis----gMEKHEIYEMMELIFKIDRRINESVESRGLIHVDGKKEFALGlk----rEP 208
gi 219676374 178 glrdvpetDDAPLSp---AALRShyqafglQSEAQLDACVTALRSGFECIERSLAQHGELLVDTKFEFGIAptlhggeEL 254
gi 116754803 159 --------TDRLLSr---DEALEla----kLSPQEFEEITEIIIRIDEDIRRCVEPRGLIHVDGKKEFAFDen----rEI 219
gi 219678823 180 gipgvpeaDDVNVSrsilRAHWRaf---dfRASATSIATSSCYAPALTLSAAISPGQGRIFVDTKFEFGYVhsesgtlEM 256
gi 110669014 195 --------QDRYLDr---EEAERi------AGAASIDTLEELAVSVNRIITREAEKRGFVHEDGKIECLYHd-----gEI 252
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #     ####                                                                   
1OBG_A       229 ILVDEVlTPDSSRFWNgasykvgesqdSYDKQFLRDWLTANKlng------------------------vngVKMPQDIV 284
gi 9664578   216 VLVDTFgTLDEDRWWDaeays-ngeciELSKEFVRTHYINSGhqaelklar------------dsgaidppiPALPESVI 282
gi 22001871  209 IIVDTFgTADEDRFWEkkeyd-agrivELSKEMVRQYYRSTGyhdrlyear------------srgmpepdiPPLPEDMA 275
gi 22001872  243 RVADVAgTFDENRFRFdg--------rEVSKEAVRQFYKRSDpewvgavkdakraadergvadwkslcepspDPLPPEIL 314
gi 197624536 209 YLVDTFgTLDEDRWWDkdaye-rgkivQLSKEFVRQYYRSIGyyeelkmar------------eegkeepeiPPLPKDMV 275
gi 48478425  209 VVCDTFgTPDEDRFWDlkeyk-knnimELSKEMVRQYYRETGyherlysar------------enhekepdiPPLNDEMI 275
gi 219676374 255 IYMDEVgTPDSSRIWRqddwq-rgqpkEHSKEQFREALMAWVedrdmlldpar---------mtersafakaNPVPDTFF 324
gi 116754803 220 MVVDVYgTADEDRFWDramye-egeyvDLSKEYVRKYYRQIGykdmlyqar------------sskmpepeiPPLPDEIV 286
gi 219678823 257 IYMDEVgTPDSSRIWEgdayr-qgqvvERSKEAFRQALLDLApdpavlldkqr---------maerlafaatTTLPLELM 326
gi 110669014 253 ILADVVgTFDENRFGYnd--------qEVSKEVIRQQYKQIDpewvsavtdakrqakiqdvadwrghcdrspTPLPQPFI 324
                        410
                 ....*....|....*.
Feature 1                        
1OBG_A       285 DRTRAKYIEAYETLTG 300
gi 9664578   283 EETASLYSSMYERLTS 298
gi 22001871  276 RKVSDLYKTMYERITG 291
gi 22001872  315 QAAADLYAAGANRYTA 330
gi 197624536 276 EKVSKLYVEMYERITG 291
gi 48478425  276 KRISNLYIDLYQKITG 291
gi 219676374 325 EDLSHTYAAQAERILG 340
gi 116754803 287 QRTSEIYIKLYERITG 302
gi 219678823 327 MDVSQNYLGLGREITG 342
gi 110669014 325 NTISDLYAAGTNAYVD 340

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