2H31


Conserved Protein Domain Family
SAICAR_synt_Ade5

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cd01416: SAICAR_synt_Ade5 
Click on image for an interactive view with Cn3D
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
Eukaryotic group of SAICAR synthetases represented by the Drosophila melanogaster, N-terminal, SAICAR synthetase domain of bifunctional Ade5. The Ade5 gene product (CAIR-SAICARs) catalyzes the sixth and seventh steps of the de novo biosynthesis of purine nucleotides (also reported as seventh and eighth steps). SAICAR synthetase converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.
Statistics
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PSSM-Id: 133471
View PSSM: cd01416
Aligned: 20 rows
Threshold Bit Score: 330.409
Threshold Setting Gi: 189313912
Created: 30-Apr-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 32 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:by similarity to other members of this superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               # #### #           #           #                                 #       
2H31_A         7 LNIGKKLYEGKTKEVYELLDSp--gKVLLQSKDQITAGNAARKNhlEGKAAISNKITSCIFQLLQEAGIKTAFTRKc--G 82
gi 189038237   1 MELGYVLTEGKTKIVYAHPTDp--dLAILYHKDGITAGDGARRSviEGKGELAGQTTANVFRLLNRAGIATHFVDAp--E 76
gi 189038194   1 MNLGEKLTEGKTKIVYAHPNDp--tLAIIIHKDGISAGDGARRHiiPGKGALSGRTTANVFTMLNHAGVATHFVAAp--E 76
gi 159901346   1 MQYGTKLAEGKTKIIYAHPEDq--sLAYMVQKDSISAGDGARRNeiDGKGAISGRTSANVFALLNRSGVRTHYQSDp--E 76
gi 156349396   1 MKIGEKIIEGKTKIVYALPDSpdgnHVLLKSKDKITAFDATRKDemSGKAAQSTATTCAIFEMLKACGLKTHFVKRcesD 80
gi 221124644   6 YGANDLIIEGKTKAIYALPEYldgqYVIMKSHDQITCGDGARKDilIGKGALSNATNAAIFEYLNNAGVRTHFHRSv--S 83
gi 167536630   2 EMLGKTIVEGKTKVVHQHARNf--dQVILVSKDRITAGDGARAHeiSGKAKVANDTTCTIFEFLNSVGIPSHFVAR---S 76
gi 196006411  13 IKIGRKIIEGKTKVVFAIDDPtscnLVVLRSKDAITAFDGQRAHemSFKGKYSTATTCGVFDLLQYCDVPTHYRYHy--D 90
gi 198423438  50 FTLGKMFCEGKTKVVYEINTKtp-gRCLIVSKDIITAGDGAKRNvmEGKAELSSATNAAVMQMLNDFGLKTAFIKGv--N 126
gi 66810153   16 LKDKTFLASGKTKTIYQLNKEd--qYVLIESNSAITAGDGAKKDilPNKDIYSTTTTVNNFKVLQLSGINTHFVKQv--E 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #### #   # # #   ###                        # #     #                      
2H31_A        83 ETAFIAPQCEXIPIEWVCRRIATGSFLKrn---pgVKEGYKFyPPKVELFFKDDaNNDPQWSEEQLIAAKFcfa---gll 156
gi 189038237  77 PRLTVVRRCRMIPLEVVMRRLPAGSYLRrh----pEAAGQRFdPPLVEFFLKDDaRHDPQIAPQEIIAQGI--------- 143
gi 189038194  77 PTVMIVRRCVMIPLEVVNRRIATGSYIRrh---pdVAEGTRFdPPLLEFFLKDDaRHDPQISPEEIVAQGI--------- 144
gi 159901346  77 PGVMLVERCEMLPLEVVMRRLATGSYCRrh---peTPEGTRFsPPLVEFFYKDDaNHDPQIYLEGIVEKGL--------- 144
gi 156349396  81 PEAFIGIACEMIPLEVVCRRIATGSFLKry---pgVKEGYRFtPPKQEFFLKDDaQHDPFWTYEQCVEAAFeig---gkk 154
gi 221124644  84 ETECIVERCQMIPLEIVSRRLATGSYLKrn---pgVNEGFRFsTPKMEYFFKDDaNHDPQWSSDQILENKLmig---glt 157
gi 167536630  77 GDMMVAKKVHMIPIECVARRVAYGSYLRrfktpfpVTEAYRFpTPCLEFFYKDDaNHDPQVTKEQLLSNPLlldeakqlr 156
gi 196006411  91 ENSFVAIFCNMIPLEVVVRRIATGSFLKrh---qgVKEGYRFsPLKLEFFYKDDaQHDPLVSIEQILHMKLtag---kvv 164
gi 198423438 127 KKSFLAWKCDMIPIEWVARRVATGSFIRrh---vgVKEGYRFsPPKLETFYKDDeNHDPQWSREVLEEAKLkcg---kiv 200
gi 66810153   92 PNAFIAKKCSMIPLEVIVRRLATGSYLKrn---thVTEGTKFnPPLIEFTFKDDvQHDPLVTEQDILEMNLkig---gvp 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        ### #             #    ####                     
2H31_A       157 IGQTEVDIXSHATQAIFEILEKSWLPQNCTLVDXKIEFGVDvttkEIVLADVIdNDSWRLWPSGDRSQQKDKQSYRDLKE 236
gi 189038237 144 ATPAEVEQMTDTGRKVFVTLEAAWQQLDVTLVDLKIEFGRTaq-gDLLVADVIdNDSWRIWPSGDPAQMLDKQVYRNAQV 222
gi 189038194 145 ASADEVEQLASESRRVFLLIEEAWAAQDIVLCDLKIEFGRDas-gALVVADVIdNDSWRIWPGGMKERMLDKQVYRNMPV 223
gi 159901346 145 ATAEEVSFIEQEGTRVFELLEQTWAERGVQLVDLKIEFGRTad-gSLIVADMIdNDSWRLWPDGDKSKMLDKQIYRNLQT 223
gi 156349396 155 IGKHELDIMSESAIAIFEIIERAWATVDVALVDMKIEFGVNrktgELMLADVVdNDSWRIWPSGDKRLMRDKQVYRNLPE 234
gi 221124644 158 IGQFELDEITLVAKTCFEILEKAWASRNCVLVDMKVEFGVTiknkEIVLADVIdNDSWRIWPAGDKRLMKDKQVYRNLSV 237
gi 167536630 157 LTPKYVEQMELWTRAVFETLERAWAVQGCTLVDMKIEFGIDmq-gRLILADVIdNDAWRVWPQGDRRLMKDKQFYRELKT 235
gi 196006411 165 IGKDEIDIMSKVALATFEILERAWSTLNCNLIDLKVEFGVSas-gTLLLADVIdNDSWRLWPSGDKRLQKDKQAYRDLKQ 243
gi 198423438 201 VTPDLIDIMEKMTITIFEVLEKAWKSKNVSLIDMKIEFGVRqdtnEIVLADVIdNDSWRIWPSGDKRLMKDKQVYRNLKE 280
gi 66810153  166 ITSKLLSQTRHIATLSFEALERAWQSLDVTLVDFKVEFGITsq-gELILADVIdNDSWRIWPKGDKTLMKDKQVYRNLPS 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
Feature 1                                                 
2H31_A       237 VTP-------------------EGLQXVKKNFEWVAERVEL 258
gi 189038237 223 VDE-------------------ALLADVRARYALVAELTGR 244
gi 189038194 224 VTD-------------------DGLEQVRRLYEEVAHRTDA 245
gi 159901346 224 VTE-------------------EALQNLKAKYEEVRDITES 245
gi 156349396 235 VTP-------------------EALEQVKKNYAWVAGESQK 256
gi 221124644 238 VTT-------------------EAMSEIRKNYTWVSNEVKL 259
gi 167536630 236 VTD-------------------ADLTEVLKKYEWVADAVRG 257
gi 196006411 244 VTD-------------------QAMEEIRGNYAWVAKKIDQ 265
gi 198423438 281 VTN-------------------GDMQNLKENYTWVSNQLTA 302
gi 66810153  245 ALNtpgatpttqsgpllntlsdQQLKMIEDNYAWVATSTEK 285

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