1P87,3BCH,1VI6,1PNS,2HGR


Conserved Protein Domain Family
RPS2

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cd01425: RPS2 
Click on image for an interactive view with Cn3D
Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ribosomal protein S1 to the 30s ribosomal subunit. In humans, most likely in all vertebrates, and perhaps in all metazoans, the protein also functions as the 67 kDa laminin receptor (LAMR1 or 67LR), which is formed from a 37 kDa precursor, and is overexpressed in many tumors. 67LR is a cell surface receptor which interacts with a variety of ligands, laminin-1 and others. It is assumed that the ligand interactions are mediated via the conserved C-terminus, which becomes extracellular as the protein undergoes conformational changes which are not well understood. Specifically, a conserved palindromic motif, LMWWML, may participate in the interactions. 67LR plays essential roles in the adhesion of cells to the basement membrane and subsequent signalling events, and has been linked to several diseases. Some evidence also suggests that the precursor of 67LR, 37LRP is also present in the nucleus in animals, where it appears associated with histones.
Statistics
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PSSM-Id: 100106
View PSSM: cd01425
Aligned: 170 rows
Threshold Bit Score: 79.9333
Threshold Setting Gi: 15150717
Created: 12-Dec-2003
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:rRNA interaction site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                            ##        #   ##                                            
1P87_B         8 MLKAGVHFGHQTry----wNPKMKPFIFGAR---NKVHIINLEKTVPMFNEALAELNKiasrkgkILFVGTkr------- 73
gi 74325179    5 LIKTRNYKLFKYn------LLKLQIYSNESSfniSTFSNNVLEQIEAYLKQVLKIIFEyhmyqfkILFIGFp-------- 70
gi 50261299   20 LFKSKNFYGESLke----tKKKNLPFIYGFR---HNYSIINLKATIFFLQKALFLIKLcikknkkILIIGDsfdikflls 92
gi 84508595   13 FIGSSGYLVPRSvnenikiSKTMHPYLLGKR---NSYYFYNLEKSLYGIRASLEVLKNiiedngeILFVSDlp------- 82
gi 15150717   13 FIGSSGYLVPRPqneyvkiSKTMHCYLLGKR---NNFYFYNLEKSLYGIRATLEVFKNivakegkILLISNs-------- 81
gi 160688767  20 FLRSEFYIGCKKsr----wNPLLIGFIYKLR---KKIYILNLEYTVFQLRRSLNMIKNiirnrgqILMVMIkk------- 85
gi 187764108  22 LVRNEFYIGGQKar----wNPLLVGFLYKIR---KGMLIINLEYTIFQIKNGLNLIKNivrnrgkIMILVLkk------- 87
gi 161899531  10 LIYSQNYIGAAYv------DFRMKNHIIKQKn--NLNNKINLFTTYKNLIYLPSLLFSiss-mrkLAIIDTkc------- 73
gi 1173298    12 LVASDLFLGYHIan----wNPRTNFFLIGKY---KNTNIFNLNYTYFLAKKFIVFLSElfvnkghLWLVNEnfsl---fn 81
gi 110225641  21 FFKLSAHIGNKKw------HPTMSSNLIASR---NAVYILDISKTIKGLFNALDVISSivsqkghILFINSnp------- 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                              # ###  ##                                                 
1P87_B        74 aASEAVKDAAlsc--dqFFVNHRWLGGMLTNwktvrqsikrlkdletqsqdgtfdkltkkealmrtreleklenslggik 151
gi 74325179   71 vVSKLKQMRLmhftnhdFISEKSWISGIFRNrfsiltyltliqsqn-------------------------fsknlklll 125
gi 50261299   93 eSKKINFTQKnk---niILKNDIWINGLLTNktvsnf------------------------------------------- 126
gi 84508595   83 aLKYAFGKNPn-----iNCINLKRSSLANSGd------------------------------------------------ 109
gi 15150717   82 -LTLESRFALe-----sNINYLKWKRGSLSKsq----------------------------------------------- 108
gi 160688767  86 kISNLVKTLLkks--kqGYVDYKYYNGSLIHfkeskkllyqkstgnievd-----------------lkektfikmlgyk 146
gi 187764108  88 kINNIVKILLtkn--kqGYVVYKYSHGSLMRfrrmrrlfelkrmgyligk-----------------lrpitflklkgyv 148
gi 161899531  74 iSRKAIKQICial--ncRGIFKNYIPGNFSNrqik--------------------------------------------- 106
gi 1173298    82 rSSELYQLYSlfp--eiTFLNSKWCKGMLSNykyvsi------------------------------------------v 117
gi 110225641  85 lYNKLLQKTCelt--eqSYVNNRWVGGTLTNwpiiskeietykkvvtqlhlytsl------fyvstpryekmkksfqgfq 156
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                               #  #                                                   
1P87_B       152 dmgglPDALFVIDa-dHEHIAIKEANNLGIPVFAIVDtnsDPDGVDFVIPGNDDa------IRAVTLYLGAVAATVRE 222
gi 74325179  126 svktkPHLVVVFNq-kVETNVINEFYKAGIPILSFNCkplNMPKITYKTLGNFKfvetnlrTAYFFLFYSILKRPPLT 202
gi 50261299  127 lkhnkINLIILLKsktKENYLLTEFNHKNIPIITLNNtnsNIDYINYPIFSNTKn------LKSLFFLIYLIRKTFLK 198
gi 84508595  110 -----SDLIFLSG---VRKENLVEAHRKCTPLVGVGSf--TMSKIAYPFNLNIDs------ILLSYWFFNAIYATCDR 171
gi 15150717  109 ----dVDLVFLSG---VNRENLVEAHRKCLLLSGVGSs--TMSKIAYPVNLNIEs------PLLSDWFLGALYTSYIQ 171
gi 160688767 147 nlqkkPSAVIITQt-nKSDWLIRECNRLKIPTICFIDsntMSLLYTYSIVGNSNt------NKHLNLILLFIYHAIFQ 217
gi 187764108 149 alrrpPALLVLTTg-nKQEDIYRESLYAGIRVLSFIDtntMTLWQSHTVVGNSKt------NKNINLILLLINYAIFF 219
gi 161899531 107 -sfmlPEAAIVAEp-kNDPRIIRELSNINIPIIGICNtdtNISFIDWVLPSNTNs------KFSNAMIFYLIGRLLKR 176
gi 1173298   118 kpakfPHSIFVPNi-qNNHYVINESFIINIPSIAIVDsidNPSNVFFPIPGNSKs------LKSLFFFYMVIAKSLFY 188
gi 110225641 157 tpiskPDLLIVLNp-sKNKEAINEAWVLNIPVIAIVDsdtNLSKITYPIPGNNSs------YEFIYYCLNIIVKTITN 227

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