3B8C,3J08,1VFP,3B8E,3WGU


Conserved Protein Domain Family
P-type_ATPases

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cd01431: P-type_ATPases 
Click on image for an interactive view with Cn3D
ATP-dependent membrane-bound cation and aminophospholipid transporters
The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.
Statistics
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PSSM-Id: 319764
View PSSM: cd01431
Aligned: 55 rows
Threshold Bit Score: 82.1143
Threshold Setting Gi: 55743071
Created: 12-Dec-2003
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1: P-type ATPase signature motif, 7 residue positions
Conserved feature residue pattern:D K [TS] G T [LIVM] [TS]Click to see conserved feature residue pattern help
Evidence:
  • Comment:a characteristic P-type ATPase conserved sequence motif: DK[TS]GT[LIVM][TS], in which D is the reversibly phosphorylated Asp

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #######                                                                     
3B8C_A       325 VLCSDKTGTLTln----------klSVDKNLVEvfckgvekdqvllfaamasrvenq--daidaamvgmladpkearagi 392
gi 150025739 302 VLLLDKTGTITig-----------nRKATHFYPak--------------------------------------------- 325
gi 2506206   303 VLLLDKTGTITl------------gNRQASEFIpaqgvdektladaaqlasladetpegrsivilakqrfnlrerdvqsl 370
gi 37520143  318 TLILDKTGTITlgnrladefipvggYSVREVATaa--------------------------------------------- 352
gi 19552400  301 VVVVDKTGTLTtgr---------peLTDVEVIEpay-------------------------------------------s 328
gi 27805411  335 SLVLDKTGTITf------------gNRMADEFIpvnsy---------------------------------------tve 363
gi 27805406  337 LISSLKDLTPEgrs---------ivDLARKMGAkapdd---------------------------------------ile 368
gi 49480188  483 YIVFDKTGTLTkg-----------vFKVTKMEPsegt------------------------------------------t 509
gi 16125839  303 EAAGDVDTLLLd-------------KTGTITFGnrm-------------------------------------------- 325
gi 15896913  302 TMILDKTGTITy------------gNRLAADFItvgg-----------------------------------------ad 328
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
3B8C_A       393 reVHFLPFnpvdkrtALTyidgs---gnwhRVSKGApeqilelak-asndlskkVLSIIdkyae--------------rg 454
gi 150025739 326 giLEEDFIk------SAVlssladdtpegkSIVELAg-----------------AELAQ--------------------- 361
gi 2506206   371 haTFVPFTaqs--rmSGInid-------nrMIRKGSvdairrhveangghfptdVDQKVdqvar--------------qg 427
gi 37520143  353 -wAASVFDttp-egkSVVk----------lAASQGAaag-------------ydPEGATg-------------------- 387
gi 19552400  329 qgEVLELA-------ARAetase--hpladAIIRGA------------------QDRGLs-------------------- 361
gi 27805411  364 dvARIAKL-------ASLfdet----pegkSIVKLAe-----------------KYKILadvn----------------l 399
gi 27805406  369 gaEVVEFSa-----eTRMs----------gLNLKDGt----------------iVRKGS--------------------- 396
gi 49480188  510 seELLEYAa-----fAEVy-----------SNHPIAq----------------sIRKAYgksidekiiddyneisghgtv 557
gi 16125839  326 atEVIPAP-------GVRp----------dAAMKAAlmaslade---tpegrsiIELARn-------------------- 365
gi 15896913  329 kqKLIDYSvm----cSLKddtp----egksIVELGKqlgit--------idtkkYESIEfeeft--------------aq 378
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
3B8C_A       455 lrSLAVArqvvpekt-------------------kespgapwEFVGLLPLFDPPRh---------------dSAETIRRA 500
gi 150025739 362 --KLSIEgatlikftae---------------trtsgvvlkdGTNIRKGAQDAAKniatq-------agndfPEDITQRV 417
gi 2506206   428 atPLVVVeg--------------------------------sRVLGVIALKDIVKg---------------gIKERFAQL 460
gi 37520143  388 --IEFTAqtrmsg-----------------------tdfadgRAVRKGAVDAIKRyvq------------adGGQIPADL 430
gi 19552400  362 -tTLVEAae-------------------------------niTGRGIIANVDGQAva-------------vgSAELLDHE 396
gi 27805411  400 nqAEGVEfsaktrmsgtn--------------lpngkqvrkgAVDAIKGFIRSRGgsipsdvdvayervsllGGTPLAVC 465
gi 27805406  397 --YDKVK-----------------------------------EYIGEKGGSIPDDl----------------DKEVEKIS 423
gi 49480188  558 vkVQGKE-----------------------------------IFAGNAKLMRKENit-------------fkQPETVGTL 589
gi 16125839  366 -aGLALEapegataipftaqtrqsgldhqgrswrkgavdavyRTLGLEPQSIPTEl----------------SVAVDRIA 428
gi 15896913  379 trMSGIKle--------------------------------nGTAVKKGAYDAIKkrvqelkg-vipkdldeAVNKVAKL 425
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
3B8C_A       501 ln--------lGVNVKMITGDQl-----AIGKETGRRLGMgtnmypssallgthkdanlasipveeliekaDGFAGv--- 564
gi 150025739 418 iais----skgGTPLVVVKNNQv-----QGVIELQDIIKTgmke------------------------rfdRLRKMgvkt 464
gi 2506206   461 rk--------mGIKTVMITGDNr-----LTAAAIAAEAGVd------------------------------DFLAEa--- 494
gi 37520143  431 daaterisrlgGTPLAVCAGNIv-----YGVIYLKDIVKPgm----------------------------rERFEQlrrm 477
gi 19552400  397 pdstrilelnaEGKTAMFVGVNgh---aIGIVAVADAVRSdsasaies----------------lhkagiqVVMATgdah 457
gi 27805411  466 qdnei--fgviYLKDIVKSGLR------ERFEQLRRMGVKtimltg-------------------dnhitaSVIAQeagv 518
gi 27805406  424 ll--------gGTPLVVVKDNEv-----LGVIYLKDTIKPgm----------------------------kERFKQlram 462
gi 49480188  590 vhva----vdgKYAGYIVISDEvkedskQAIQKLKELGIK-------------------------------KTVMLtgda 634
gi 16125839  429 rs--------gGTPLAVSEDGVl-----VGVIHLKDVVKPgvke-----------------------rfadLRRMGlrtv 472
gi 15896913  426 g----------GTPLVVCVDNKi-----YGVIYLKDTVKPglverferlreigi---ktimctgdnpltaaTIAKEagvd 487
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
3B8C_A       565 -------------------------------fPEHKYEIVKKLQerk-----------hiVGMTGDGVNDAPALKKADIG 602
gi 150025739 465 vmvtgdnpltak----fiaqaagvddfiaeakPEDKMNYIKNEQqng-----------klVAMMGDGTNDAPALAQADVG 529
gi 2506206   495 -------------------------------tPEAKLALIRQYQaeg-----------rlVAMTGDGTNDAPALAQADVA 532
gi 37520143  478 giktvmltgdnritasviaaeagvddfiaeatPEDKIRVIRENQaqg-----------klVAMTGDGTNDAPALAQADVG 546
gi 19552400  458 rvaqnvas------------klgvdevysellPEQKLELVRDLQaag-----------ktVAMVGDGVNDTPALAAADIG 514
gi 27805411  519 dd------------------------fiaeatPEDKIDVIRNEQsqg-----------klVAMTGDGTNDAPALAQANVG 563
gi 27805406  463 giktimitgdnpltaktiaeeagvdefiaeskPEDKINVIKREQaqg-----------rlVAMTGDGTNDAPALAQADVG 531
gi 49480188  635 klvge-------------------avgkelglDEVHAELLPQQKveeiekidaakhgkekIAFVGDGINDTPVLARADVG 695
gi 16125839  473 mitgdnpvtaaa-----iaseagvddflaeatPEDKLRLIREEQgkg-----------rlVAMCGDGANDAPALAQADVG 536
gi 15896913  488 gf-------------------------iaeckPEDKIEAIKKEQdeg-----------klVAMTGDGTNDAPALAQADVG 531
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
3B8C_A       603 IAVAd-ATDAARGASDIVltepglsviisAVLTSRAIFqrmkNYTIYAVSITIRIVFGFMLIaliwe-fdfsAFMVLIIA 680
gi 150025739 530 VAMNs-GTQAAKEAGNMVdldndptklieIIEIGKQLLmtrgTLTTFSIANDVAKYFAIVPAlfitaipaleGLNIMRLQ 608
gi 2506206   533 VAMNs-GTQAAKEAGNMVdldsnptklieVVHIGKQMLmtrgSLTTFSIANDVAKYFAIIPAafaatypqlnALNIMCLH 611
gi 37520143  547 VAMNs-GTQAAKEAANMVdldsdptklidVVTIGKQLLitrgALTTFSIANDVAKYFAIIPAmfsa--agigVLNVMALT 623
gi 19552400  515 VAMGvaGSPAAIETADIAlmadrlprlahAVTLAKRTV----RTMRINILIALATVMVLLAGvlfg--gvtmSVGMLVHE 588
gi 27805411  564 LAMNs-GTQAAKEAANMVdldsdptklidLVTIGKQLLitrgALTTFSIANDIAKYFAILPTifga--agigALNIMGLK 640
gi 27805406  532 LAMNs-GTMAAKEAANMVdldsdptkiieVVGIGKQLLmtrgALTTFSIANDVAKYFAILPAiisetlpaikVLDVMKLS 610
gi 49480188  696 IAMGglGSDAAIEAADIVimtdepskiatAVKIAKRTRsivwQNIIFALGVKGIVLLLGAFGiatm---weaVFSDVGVT 772
gi 16125839  537 VAMQt-GAQAAREAGNMVdldsdptkvieIVEVGKQMLitrgALTTFSIANDVAKYFAIIPAmfvvslpalgALNVMKLH 615
gi 15896913  532 LAMNs-GTTAAKEAANMVdldsdptkvleVVEIGKQLLitrgALTTFSIANDVAKYFAIIPAiftiaipkmqLMNIMHLS 610
                        490
                 ....*....|.
Feature 1                   
3B8C_A       681 ILNDGTIMTIS 691
gi 150025739 609 SPESAILSAVI 619
gi 2506206   612 SPDSAILSAVI 622
gi 37520143  624 SPTSAILSALV 634
gi 19552400  589 ASVLLVISIAM 599
gi 27805411  641 SAQSAIISALI 651
gi 27805406  611 SPTNAILSALI 621
gi 49480188  773 LLAVLNAMRVL 783
gi 16125839  616 SPESAILSAVI 626
gi 15896913  611 TPYSAILSALI 621

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