Conserved Protein Domain Family
PBP1_ABC_xylose_binding

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cd01538: PBP1_ABC_xylose_binding 
Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily
Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes a transition from an open to a closed conformational state upon ligand binding. Moreover, the periplasmic xylose-binding protein is homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR.
Statistics
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PSSM-Id: 107251
View PSSM: cd01538
Aligned: 56 rows
Threshold Bit Score: 235.953
Threshold Setting Gi: 15828814
Created: 1-Jul-2004
Updated: 29-Oct-2018
Structure
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Aligned Rows:
 
putative ligand
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the periplasmic transport protein receptor for D-glucose and D-galactose

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #                                                                 
gi 1175039    27 KIGLSIddl--rleRWQKDRDIFVNKAes---mGAKVFVQSANGddSAQISQIENMINKNIDVLVIIphngevlsnvise 101
gi 148260966  43 TIAFLLpens-sprYEQVDRPWFIKMAhaa-dpNAKLIVSNANSspDTQLNQAESAISNGADVLVVDpvdgkagaaivny 120
gi 117928339  59 QVGVILpdtqsstrWESQDRPNLQKAFqa---aGIKADIQNALGdkNKFAQIADSMIQEGVKVLIIVdldspsgaaveak 135
gi 119716603  54 KVGVILpdsktsvrWETQDRPNLEAAFka---aGLESIIQNAEGspDTFGQLCDQMITEGVQVLIETdldpdsgkacidk 130
gi 152968019  41 HVAFLVpat--slrFMAYDVPNFSVELaqr-cpTCVVDVQTAEDq-ATQNAQGVQAIRDGAEAVVVValdgaaagdlvsa 116
gi 62423094   50 TIALLLpesk-ttrYESLDKPNFEKYVaea-npDAKVEYRNANQdaTQQQQQFEAAVTEGVDAIVLDpvdasavtsalsk 127
gi 21224344   48 KVGLLLpenq-tarYEKFDKPMIEKKVkeltnnKGEVVYANAKQdaSLQNQQVDTMVTNKVDVMIIDavdykaiagsvkk 126
gi 21222081   45 LVGLLLpeke-ntrYEQFDYPFFKKKVgeltrdEGIVKYANAEAsaTKQADQMQQMIEDKVDVIVLDavdahaiadgvqk 123
gi 17985196   24 VVGFLMpdqa-strYEERDYPGFAAQMktl-ceSCKVLYLNADGdaTKQQQQFNSVISQGAKVIVLDavdtaaaaslvkl 101
gi 111017248  35 KVFFFLpntt-ttrFVERDEPLFTDFLelf-apEATVTVRNAEGdpARQQSQVESAIAEGASVLVLIstdarfsggalta 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #                                                            #       
gi 1175039   102 akkeGIKVLAYDRLInnadlDFYVSFDNEKVGELQAKSIVav----------kPEGNYFLMGGSPVDNNAKLFRKGQMKV 171
gi 148260966 121 aarnHVKVISYDRLIqdskpDYYVSFDNTKVGELQGEYIAkh---------tkPGGSVMMINGAPTDPNAFDFRKGAMNV 191
gi 117928339 136 aaqaGIKTIDYDRLTlggsaSYYVSFDNVQVGKLMGQGLVdclkdkaasattsNPVRIIEINGSPTDNNATLFKQGYDSV 215
gi 119716603 131 aknaGIAVIDYDRLTlgggaDYYVSFDNVKVGALQGQGLIdalq-----akgeKSGNIAFINGAATDNNATLFKQGYEQV 205
gi 152968019 117 ansaDVPVVAYDRLLkdsaiDYYTSFDGGAVGELGGQAILdaig------tdtAGGAIVMLQGDPADNNAGLFAAGAHSV 190
gi 62423094  128 aqakKIPVIAYDRFFeg--aDYYTSFDNKKIGNLQGQAVLdglka---edkdpKSGPVWMVNGDPKDPNAADFKAGAEET 202
gi 21224344  127 ahdaGIKVVAFDRLAeg-piDAYTSFDNVTVGKTQGEALLkalg------dkaKDSQIVMMNGSSTDPNAAQFKEGAHSV 199
gi 21222081  124 akdaGIPVIAYDRLAeg-piDAYISFDNELVGEVQGRSLIealg-----gdpeSSAKIVMMNGSSTDPNAKQFKAGALSE 197
gi 17985196  102 aqsqGIKVIAYDRPIpdaksDFYVSFDNEAIGKSIAESLVkhlkd---kgvptDKGGVLQINGSPTDAAAGLIKNGIHAG 178
gi 111017248 113 aaeaDVPVVLYDHDAvggpaDVQVIFDPLEVGRRQGSRAAdlia-----ampgDGVKIARVGGNLGEYGTRQFLLGQDEF 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   #    
gi 1175039   172 LDPliasgkiKVVGDQWVDSWlaEKALQIMENALTank-nnvDAVVASNDATAGGAIQALSAQGLsg-kVAISGQDADla 249
gi 148260966 192 LGPlfksgklHLAYSVMTPDWspQNAFEESQQALTrlh-nkvNAVLAANDGTASGVIRALQAVGLag-kVPVTGQDATng 269
gi 117928339 216 LDPlyatgkwKKVGDQSVPNWdnAQAGTIFQQLLTaag-gkvDGVLVANDGMAQSVITVEKSQGLk---APVTGQDATvp 291
gi 119716603 206 IKDdg----sYTVVGDQTGEWdpDTAGKVFDQFYAahp--dlVGLVTANDGMAGGVIAREKAAGVeg-kILVTGQDATae 278
gi 152968019 191 LDGk-----vDVASERYVAGWsaDQAAVEMRAALGelngrrlLGVYTAYDGLAAGALQALDEAGLs--gVPITGQDAEta 263
gi 62423094  203 LKKag----vDITESHDTLDWnpDDARQWVEGQLQsad-kepIAIYSANDGTAGGVLAATKKAKVk---PVVTGQDAEvd 274
gi 21224344  200 LDGk-----vKIGREYDTKEWkpENANANMEAAISalgkdkiDGVYSANDGMAGGSITALKRAGIa--dIPVTGQDAEla 272
gi 21222081  198 LNGk-----vTIAQSFDTKDWkpENAEANMTEAIEkigkkkiAGVYSANDGMAGGVIKALEDAGVtd-lPPITGQDAEla 271
gi 17985196  179 LKDsg----yKTLAEYDTPEWapSKAQQWASGQITrfg-dqiVGVVAANDGTAGGAIAAMKAAGVdp-lPPVTGNDATia 252
gi 111017248 188 LQPladsgkiRVVCETAIDDWdpAEGQAFAEECLAren-ndiALFVTMNDDLGGGIVAALAGRGLagriPVTGGQDANla 266
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1                       #                                               
gi 1175039   250 AIKRIVNGSQTMTVYKPiTKLADKAAEIAVelgkneki-----eanaelnNGLKNVPAYLLDP 307
gi 148260966 270 GLTFILEGLQSMTVFKYvPEEAAAAAELAVavatdtkpp--agllngktnNKMIDVPSVLLKP 330
gi 117928339 292 GLQSVLRGDQCGTVFKNtSLEASAAAQLAIdliqgkdpgs-lingkvhdpQGNRDVPSALQTP 353
gi 119716603 279 GLANVLLGYQAGTVFKDtSIEAKAAADLAIaiikgedpst-iatgsvndsVLGVDVPSVLATP 340
gi 152968019 264 ALQRILAGTQTMTVYKDlPGQARATADLVAdvlegktp-----attgttdNGAGAVPTVLLQP 321
gi 62423094  275 GLQNILRGDQYATIYKSiPPQAEFAAKAAValaggeep----kagttykdTPTDFVEAKVVTT 333
gi 21224344  273 GVQRIVTGEQYMSVFKSyPKEAETAAEMAValakgesld--siandkvdsATTKGVPAVIVPV 333
gi 21222081  272 AVQRIVTGEQYMSVYKSyPQEAENAAEMAVarvqgrdiqfdalardkvdsPTHKGIPAQLVPV 334
gi 17985196  253 ALQLIISGDQYNTINKPsEIVASEAARVAVqllgdkapk---aettlyntPSKLFVPVVVTAE 312
gi 111017248 267 ALQLIAQETLDNTIFKNlSDQAKVAAQLTTsilhgdgip--eeivngtidNQYMAVPTVFLPV 327

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