Conserved Protein Domain Family
PBP1_GGBP

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cd01539: PBP1_GGBP 
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Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species
Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species. GGBP is a member of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes transition from an open to a closed conformational state upon ligand binding. Moreover, the periplasmic GGBP is homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR.
Statistics
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PSSM-Id: 107252
View PSSM: cd01539
Aligned: 46 rows
Threshold Bit Score: 325.71
Threshold Setting Gi: 149751882
Created: 1-Jul-2004
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindingcalcium binding
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1GCA_A; Salmonella typhimurium glucose/galactose binding protein binds galactose, contacts calculated at 3.5 A.
    View structure with Cn3D
  • Citation:PMID 8240551
  • Structure:2HPH_A; Escherichia coli glucose/galactose binding protein binds glucose, contacts calculated at 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ##                                                      #           
2HPH_A         5 RIGVTIYKYdDNFMSVVRKAIEQDAka------apDVQLLMNDSQNDQSKQNDQIDVLLAkGVKALAINLVDPAAAGTVI 78
1GCA_A         4 RIGVTIYKYdDNFMSVVRKAIEKDGks------apDVQLLMNDSQNDQSKQNDQIDVLLAkGVKALAINLVDPAAAGTVI 77
gi 28210576   50 KVGVALYKFdDTFISTVRDAIKENSdvksk-etgeKIVINAVDGQGQQATQNDQVDTFITqGYDVIAVNMVDRTAASVLI 128
gi 154496617  18 RVGVALYTQdDTFISAVAQDLERLAreaegssgdlKINLSVADGRSNQTTQMEQIDQFLSrGCDVLCVNIVDRTAAAVLI 97
gi 3322834    27 TIGVVVYQYdNTLVARLRHILSTVGk--------kHARILIVDSQASQSIQNKHIDQFIArGVHGLAVNLVDHRAARTVI 98
gi 149905710  45 LIGSAIYKFdDTFMTGVRTAMEGEAke-------kGSTIELVDSQNKQPTQNEQVDTFITkGVNALAINPVDRTAAGPII 117
gi 150019245  45 LIGSAIYKFdDTFMTGVRTAMEGEAke-------kGSTIELVDSQNKQPTQNEQVDTFITkGVNALAINPVDRTAAGPII 117
gi 160938056  59 KATVIWRAFdDQFQSGFRIIMQNEAek------sgGITLDMQDAANDVSTANSKLEVALSkKTDVVAICAPDRESIENMM 132
gi 160936375  56 RIGVLLYRGdDTFIGTLRTGLEDKAkeyeq-etgiKVKLDIMDAKGSQNTQNSQVERLISlGCDALCINSVDRSSASIII 134
gi 145848800  35 YVGVTCYDQnDTFLSELLVCFKEELnhln--kngvETTVTVKNAAGSQRTQNDQVKELINaGCNVLCVNLVDRADPSEII 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     ##                                                              #  
2HPH_A        79 EKARgqNVPVVFFNKEPsrkaldsYDKAYYVGTDSKESGIIQGDLIAKHWAANqg-wDLNKDGQIQFVLLKGepghpDAE 157
1GCA_A        78 EKARgqNVPVVFFNKEPsrkaldsYDKAYYVGTDSKESGVIQGDLIAKHWQANqg-wDLNKDGKIQYVLLKGepghpDAE 156
gi 28210576  129 EKAEkaNIPVVFFNREPvkedmdkWNKMYYVGAKAEESGAMQGQIIADYWKKNpt-aDKNKDGKLQYVMLEGepghqDAI 207
gi 154496617  98 DKAEeaGVPVIFFNRQPvaediqrWEQIYYVGARAEEGGTLQGQLVLEAWQADqarwDRNGDGVVQYAMLEGepghqDAL 177
gi 3322834    99 EKAQqaRIPLVFFNRMPdlsdlnrYARAYYVGVKDDELGLLQSRLVAQYLERTps-aDKNADGIIQCVVLKGdpdhkSGA 177
gi 149905710 118 EKAKakKLPIVFLNREPekadmdsYDKVWYVGAHAEQSGTLSGQLIADYFKAHpe-aDKNHDGVVQYVMLQGepghqDAT 196
gi 150019245 118 EKAKakKLPIVFLNREPekadmdsYDKVWYVGAHAEQSGTLSGQLIADYFKAHpe-aDKNHDGVVQYVMLQGepghqDAT 196
gi 160938056 133 KKCDadGVPAVFFNMEPmedtmnrYENIWYVGAQAKQSGEMCAQALINYWNDNkdiaDKNGDGKLSLVILQGeigqqDVT 212
gi 160936375 135 DKAMdaGTPVVFFNREPveedmnrWEKLYYVGADAKESAVLQGDILVDAYNQDtrtlDANGNGLVSYVLLEGetshqDSL 214
gi 145848800 113 DVAKehDVPIIFFNREPvaedmrqWDRLYYVGADAKQSGVLQGELAVEMIRQNsq-iDHNKDGKIQYVVLEGeaghqDAI 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #                        #                           #                         
2HPH_A       158 ARTTYVIKElndkGIKTEQLQLDTAMWDTAQAKDKMDAWLSgpnankIEVVIANNDAMAMGAVEALKAHNKs------sI 231
1GCA_A       157 ARTTYVVKElndkGIQTEQLALDTAMWDTAQAKDKMDAWLSgpnankIEVVIANNDAMAMGAVEALKAHNKs------sI 230
gi 28210576  208 LRTEHSVKElekeGIKTEKLATDTANWQRAQGQEKMSAWLSayg-dkVEAVFANNDDMALGAIEALKAAGYykg--dkfI 284
gi 154496617 178 LRTEYSVKAltdgGLEVEKLSSDTANWNRGQAEAKMQQWLEkyg-seIEVVFANNDDMALGAIDAVQEAGLe------mP 250
gi 3322834   178 RCARYVCQAlreiGLKGEIIGEAFALDSRVKGQAAMHTLIHthg-drIEAVFANNDDAALGAIEALQSAGFfke--nkrV 254
gi 149905710 197 LRTEYSIKAieaaGLKTQKLAADTAMWDKAKATDLMKAFMTgqgvdkIEAVLCNNDDMALGAVEALKAEGYnkgdaskyI 276
gi 150019245 197 LRTEYSIKAieaaGLKTQKLAADTAMWDKAKATDLMKAFMTgqgvdkIEAVLCNNDDMALGAVEALKAEGYnkgdaskyI 276
gi 160938056 213 LRTDAYKETleknGIEYEILACDTANWDQAQALDKMNAWITaygidgIEGVLCNNDSMAMGAVQACINNGYnsgdaekfV 292
gi 160936375 215 IRTEWSIQTlkdgGVPLEKITGGIANWDRSQASALMEQWLKeyp-gqIELVVSNNDDMALGAIDAMNRAGIga----nsI 289
gi 145848800 192 IRTENAVDTlnknGIELEKLSYQIANWNRAQAQNRMEQMLGqyk-nkIELVLANNDDMALGALDAYKNLNYtea---llP 267
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #                   #                                                      
2HPH_A       232 PVFGVDALPEALalvksGALAGTVLNDANNQAKATFDLAKnladgkgaa-------------------dgtnwkidnKVV 292
1GCA_A       231 PVFGVDALPEALalvksGAMAGTVLNDANNQAKATFDLAKnlaegkgaa-------------------dgtswkienKIV 291
gi 28210576  285 PVVGVDATAPALdslkaGEMLGTVLNDAKNQGKAIFDIAYslakeedpi-------------------ksvegitdgKYK 345
gi 154496617 251 LVVGVDATAPALeavaaGTLQGTVLNDAQGIAGAMLDLVLalsrgedpa--------------------eavnledgHYV 310
gi 3322834   255 PVVGIDATASALkaieeDLMLGTVLNDVSSQGKAILNLLFalmgdsvpsipaedstafthagngvagraavfgtaekQCV 334
gi 149905710 277 PVVGVDATAPALqamkeGSLLGTVLNDAQNQGKATVNIALaaaqgkeink-----------------envgfdvtdgKYV 339
gi 150019245 277 PVVGVDATAPALqamkeGSLLGTVLNDAQNQGKATVNIALaaaqgkeink-----------------envgfdvtdgKYV 339
gi 160938056 293 PIVGIDANIDALeamkaGSLLGTVLNDRKSQSDAIINVIKavhagteited----------------vvgvnctvdgKYV 356
gi 160936375 290 KVVGIDGTPVGIkaleeGYLFGTVESDKERYSQAIFDIAWslslgqdpk--------------------drvpqlegNYY 349
gi 145848800 268 VFIGIDGTDMGLkavedSSMAGTVYNDKEGQARAIAKLSAalvigkea---------------------eeikftneNYI 326

                 ....*..
Feature 1               
2HPH_A       293 RVPYVGV 299
1GCA_A       292 RVPYVGV 298
gi 28210576  346 WVPYKSI 352
gi 154496617 311 WLSYRQI 317
gi 3322834   335 WIPYKVV 341
gi 149905710 340 WIDYVKV 346
gi 150019245 340 WIDYVKV 346
gi 160938056 357 WVPYVIV 363
gi 160936375 350 WCPQRAL 356
gi 145848800 327 YLPYSKV 333

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