Conserved Protein Domain Family
PBP1_GalR

?
cd01544: PBP1_GalR 
Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism
Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism. Transcription of the galactose regulon genes is regulated by Gal iso-repressor (GalS) and Gal repressor (GalR) in different ways, but both repressors recognize the same DNA binding site in the absence of D-galactose. GalR is a dimeric protein like GalS and is exclusively involved in the regulation of galactose permease, the low-affinity galactose transporter. GalS is involved in regulating expression of the high-affinity galactose transporter encoded by the mgl operon. GalS and GalR are members of the LacI-GalR family of transcription regulators and both contain the type I periplasmic binding protein-like fold. Hence, they are structurally homologous to the periplasmic sugar binding of ABC-type transport systems.
Statistics
?
PSSM-Id: 107257
View PSSM: cd01544
Aligned: 55 rows
Threshold Bit Score: 282.876
Threshold Setting Gi: 53830046
Created: 1-Jul-2004
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the LacI family.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         ##  #                                         #                
gi 53830046   34 HIAVLTVFSEIREAsDAYWRQIYLSIEQNAqdQNIIVDEIiri---nqGINIADFATYDAIIILGDMtqkaVNQLQKINE 110
gi 148544138  63 SILVLTTHSLETEAhDPYFIQVHDGIIQEAskQNIQIKAFvrf--pnkAFQFTDAQKYDGVIVAGVFtqefYANLAKNNP 140
gi 6707008    56 QVQIITYASRRREMaDPFHRELRLAIETEIkrLNLTLKKTirvesemkKQDWTEVKKAGALLVIGNFsktaLETIYQYNP 135
gi 32450780   65 SIAVIKTHSSKRENdDPYFRLIQEGIALEAgnWNFRLETLkl-----gEVSLEQLAQFGAVLTIGAFtdetLADIYKVNQ 139
gi 49610322   79 HLAVVHFLTPSEELnDPYFTAMRIGIENRChhFAISLRNIftt---nlSSNSHTLSQAQAIICVGHFsdddIALIYSLNK 155
gi 73661937   56 RIQIITYASREKEMsDPYYREIRLAIEAEVkrLNLSLKRTiridgqqdHIDLNKIENAGAIIVIGNFsvdaLNKLKTHNA 135
gi 16265317   66 KIALVHFLDPAQELaDPYYVGVRLGIESRCqaLKSEVVKVflt---gnPPEATILEGASGVVAVGHYygdeLEWLRRHSR 142
gi 119109     64 HILAIYSYQQELEInDPYYLAIRHGIETQCekLGIELTNCy------eHSGLPDIKNVTGILIVGKPtpalRAAASALTD 137
gi 2635930    58 HIAFLYWLTDKEELeDVYFKTMRLEVEKLAkaFNVDMTTYki-----aDGIESIPEHTEGFIAVGTFsdeeLAFLRNLTE 132
gi 56911527   58 KIAFLYWITEKEDLqDVYFQTVKKGVEEEAneRQLNLTTYsi-----gDGIEAIDPQTKGVICLGRFskreLDYIRTLTN 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #            #                                             #               
gi 53830046  111 RIVLVDaktryetIDSVNPELRLMTTRILDEFYq-aGRRHIGFIGGvndlleldgsstlavEDVRSEIYRNWaeeh---q 186
gi 148544138 141 HIVLIDdyrylpaYDIIRNSYFEATQIVLDQLLe-nGLNKIAFIGGnihpmnnngettdsyQDIRARAYLMWtklh---n 216
gi 6707008   136 NMVVINnpevpdfIDSVYSDLEKTMLKLLDRIIqkhQKAQITYFGGmreemsl-dgsitynNDVRYQAYVQWckshd--k 212
gi 32450780  140 NLIVVDnhfassrYDLVHTDFAKQTEQVLDYLYe-qNHRQIAFIGGeirtvdlngqnqyllADVRTTAYENWmtihg-ls 217
gi 49610322  156 NLIFIDsaplnkkCDAVIFDREAAAREVLHYIVk-sGAERPAFIGN---------------NESRLHVFQEItqkygiyh 219
gi 73661937  136 NMVVINnpntpksIDAVYSDLDDAMTELLNRILd-kGLTKIAYIGGhhtirelngitttnaADVRYQAYQSWcekh---d 211
gi 16265317  143 HLVFADyapagdmEDTVLSDVSLAMTRLLKAVHa-mGYRRIGFIGWidafyg----pdnihSERRCRTYIDWmtrag-ly 216
gi 119109    138 NICFIDfhepgsgYDAVDIDLARISKEIIDFYIn-qGVNRIGFIGGede---------pgkADIREVAFAEYgrlkq-vv 206
gi 2635930   133 NGVFIDstpdpdhFDSVRPDLAQMTRKTVNILTe-kGHKSIGFIGGtyknpn----tnqdeMDIREQTFRSYmrekamld 207
gi 56911527  133 DVVFIDtspdedhFDSVRPHLRRMIERMIDYYLe-nGHTAIGYIGGndfdad----cggyiPDRRERAFKEYmekkg-lf 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #                                                        #             
gi 53830046  187 mspHFYTGPWHa-DTGMQGAISLLRee--hSIDALLVASDPIAIGAINALKSENLEPGIDIDVVSFDNVeLSSYLVPALT 263
gi 148544138 217 ispLITLNGWTp-KDGFDSMNTLLKd----NFQAALIASDQLTIGAYRALKQHQLKVPQDLQIISYNDSdIAEYLVPSLS 291
gi 6707008   213 tpdAHLVGWTR--EDGEQEIESLSQ-----LPDIVIAGNDMVAIGVIQGLQKNGKHIPSDVKVIGFNDLdVNQYVTPSLT 285
gi 32450780  218 dniQIKTGDWTm-AFALNATNELVKssgdqLPTAIISASDPMSIGIYRALQLKNIDIPETISVFSFDDIeMAGFMSPPLS 296
gi 49610322  220 esrCKVSQLFCi-ASGYQAMNELLQqk--eWPDVVFAATDIIAIGVYRAIQEKGISIPRQIKVIGMNDIpMAQHLNPSLT 296
gi 73661937  212 veeIVLLNGWGk-TQGEDAVKVYLEsd-haFPQVFIAGNDMIAIGILQQLQLNKKAIPEEVKLISFNDLeVIQYAVPSIS 289
gi 16265317  217 dpeLCMVEPMTp-DSGYKLAKAMLSkp--nPPKILITCNDNMALGAYRAIHETGLRIPEDIAVASFNDIpVAQFLGPPLS 293
gi 119109    207 reeDIWRGGFSs-SSGYELAKQMLAre--dYPKALFVASDSIAIGVLRAIHERGLNIPQDISLISVNDIpTARFTFPPLS 283
gi 2635930   208 eryIFCHRGFSv-ENGYRLMSAAIDtlgdqLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIsFAKYVSPPLT 286
gi 56911527  207 derFLFVGDQYavNEGYALMKRAIHslgdqLPTAFCVASDSLAVGCLQALNEERIALPERVNVFSINDAsIAQYVSPPLT 286
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
Feature 1           #                                      
gi 53830046  264 TVDLNPAALGKTALEQayelandeRDWTVWATIPGNLKYRET 305
gi 148544138 292 SINPASLSMGKIAVQRlvhclnnpNEIPIHINLPAKATWRES 333
gi 6707008   286 SVQIDIEQFGKSAVAMaedrvkkvRSNALHTIVQTRLILRES 327
gi 32450780  297 TVHIDSLEIGRVAVRLakerisdgRKTALRVEVASEIIVRDS 338
gi 49610322  297 TMRLYPTEMGEAAVDLflel-vagRHYKKHVQIGYDMVWRES 337
gi 73661937  290 SVHIPVDEFGRTAVRMaeerinntRQIAIHVVVEAQLKARNT 331
gi 16265317  294 TVKIPAELIGETAVDLller-lsgREVAKKVVFGTEIVWRGS 334
gi 119109    284 TVRIHSEMMGSQGVNLvyekardgRALPLLVFVPSKLKLRGT 325
gi 2635930   287 TFHIDIHELCKNAVQLlleqvqdkRRTVKTLYVGAELIVRKS 328
gi 56911527  287 TFRIDVKLLCQTAIDLllerlvdkRTSPKTVLMSCNPIFRKS 328

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap