Conserved Protein Domain Family
Thr-synth_2

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cd01560: Thr-synth_2 
Click on image for an interactive view with Cn3D
Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, archaebacteria and eubacterial groups. This CD, Thr-synth_2, includes enzymes from fungi and eubacterial groups, as well as, metazoan threonine synthase-like proteins.
Statistics
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PSSM-Id: 107203
View PSSM: cd01560
Aligned: 28 rows
Threshold Bit Score: 509.858
Threshold Setting Gi: 42527695
Created: 1-Aug-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
catalyticpyridoxal
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1KL7_A; catalytic residue (lys) and cofactor (PLP)
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1KL7_A         7 VYRSTRsss-------pktISFEEAIIQGLAtDGGLFIPp-tIPQVDQATLFndwskLSFQDLAFAIXRLYiaqeEIPDA 78
1VB3_A         2 KLYNLKdhn--------eqVSFAQAVTQGLGkNQGLFFPh-dLPEFSLTEIDem-lkLDFVTRSAKILSAFig-dEIPQE 70
gi 16262708    3 KYVSTTggi--------epVGFDEAVLQGFAaDGGLFVPd-rIPVIDQEQLQaf-stLSFQDLAFELVSLYidasIIPRQ 72
gi 21674845    2 IFYSTTkas--------apVTMKKATLEGLApDGGLYVPs-tMPHFSAEEIAll-enGSFNNIAFAVAKKFag-dEIPLD 70
gi 23465602    4 TFHSTRstn--------dsLTAKQAIRKGIAdDGGLFVSd-aLGKTKVDVASlp--gKSYQQIAAEVLGALl--pDFTAE 70
gi 24378595    4 VYQSTRden--------nkVSASLAILQGLArDGGLFTPt-sYPQVDLDFDQlk--tASYQEVAKLVLSAFl--dDFTEA 70
gi 29347811    2 KYYSTNkqa--------pmASLQEAVVKGLAaDRGLFMPm-tIKPLPQEFYDti-dtLSFQEIAYRVADAFfg-eDIPTD 70
gi 62511212  230 TFISTRhvwpedceqkvsaKFFSEAVIEGLAsDGGLFVPakeFPKLSCGEWKsl-vgATYVERAQILLERCihpaDIPAA 308
gi 82180385    2 KYTSTRggl--------igVDFEGVLFSGFApDGGLFMPe-dIPKVDKRTLQtw-ssYSYIQLVKEICSLFispeSIPRA 71
gi 123898412   2 RYCSTRagv--------qgRSFRDVLFSGYAaDGGMFMPe-nLPSLSAETLRsw-rrLSYRQLLCEVCELFipeqEIPRE 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                      #                                 
1KL7_A        79 DLKDLIKRSYstfr-sdevTPLVQnvtgdkenLHILELFHGPTYAFKDVALQFVGNLFEYFLqrtnanlpegekkQITVV 157
1VB3_A        71 ILEERVRAAFaf------pAPVANve----sdVGCLELFHGPTLAFKDFGGRFMAQMLTHIAgd----------kPVTIL 130
gi 16262708   73 DLRRLIDNSYrefq-rpdiVNLVPirg--nrdTYVLELFHGPTQSFKDMAMGFLMQVVDYLLgqr--------reRLNIV 141
gi 21674845   71 RLSELIDECFtf------dTPLHEld----pdTFVEELFHGPTLAFKDYGARFLARMTGYFAaee--------srLITVL 132
gi 23465602   71 ELGQCIADAYgeqwsderiTPLKPlg-----dDYVLELFNGPTSAFKDVALQILPRFMAHTTpadg-----dadeKIMIL 140
gi 24378595   71 ELDYCIANAYddkfdtpviAPLVKln-----gQYNLELFHGSTIAFKDMALSILPYLLTTSAkkqg------innKIVIL 139
gi 29347811   71 TLKQIVYDTLsf------dVPLVKva----dnIYSLELFHGPTLAFKDVGGRFMARLLGYFIkke-------gqkDVNVL 133
gi 62511212  309 RLGEMIETAYgenfacskiAPVRHls----gnQFILELFHGPTGSFKDLSLQLMPHIFAHCIpp---------scNYMIL 375
gi 82180385   72 DLEGLIDRAFirfr-hrdiVPITRlk----sgLNVMEMWHGVTHAFKDLAMSCVGELLDYFLkrk--------nkHVTIL 138
gi 123898412  72 QLEGLVSSALssfs-vpdaVRLVQlk----dsLSILELFHGETLAFKDLAMSCTAHFLQYFLrrd--------rqRATIL 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1KL7_A       158 GATSGDTGSAAIYGLRGKk-----dVSVFILYPTGRISPIQEEQXTTVpdeNVQTLSVTGt---FDNCQDIVKAIFGDke 229
1VB3_A       131 TATSGDTGAAVAHAFYGLp-----nVKVVILYPRGKISPLQEKLFCTLg-gNIETVAIDGd---FDACQALVKQAFDDee 201
gi 16262708  142 LATTGDTGPAAAWAAAGKq-----rIDCWPLYPRGMISREQERQMTTLradNVHPVGVENcpdgGDDLDLVVAELFSDek 216
gi 21674845  133 VATSGDTGSAVAYGFHGIp-----nTRVVLLYPSGKVSRLQEQQLTTAg-dNVFALEVKGd---FDDCQRLVKQAFVDqs 203
gi 23465602  141 TATSGDTGKAALAGFADAp-----gTAITVFYPEGKVSQVQELQMTTQagsNVQVAAVEGn---FDDAQSAVKRIFGDra 212
gi 24378595  140 TATSGDTGKAAMAGFADVp-----gTEIIVFYPNGGVSKIQELQMTTQvgdNTHVVAIEGn---FDDAQTNVKKMFNDsd 211
gi 29347811  134 VATSGDTGSAVANGFLGVe-----gIHVYVLYPKGKVSEIQEKQFTTLg-qNITALEVDGt---FDDCQALVKAAFMDke 204
gi 62511212  376 VATSGDTGSAVLNGFSRLnkndkqrIAVVAFFPENGVSDFQKAQIIGSqreNGWAVGVESd---FDFCQTAIKRIFNDsd 452
gi 82180385  139 VATSGDTGSSAIESVRRRe-----nMDIIVLLPHGRCTKIQELQMTTViedNVHVFSVDGt---SDELDYPIKRLFADsd 210
gi 123898412 139 VGTSGDTGSSAIRSVLGLr-----eVDIVVVFPRGRITKIQELQMTTSvaeNVHVFAADGt---SDDIDVPLRKLFADad 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1KL7_A       230 fn------skhNVGAVnsINWARILAQXTYYFYSFFQAtngk----dskKVKFVVPSGNFGDILAGYFAKKXGLPIEKLA 299
1VB3_A       202 lk------valGLNSAnsINISRLLAQICYYFEAVAQLpqe-----trnQLVVSVPSGNFGDLTAGLLAKSLGLPVKRFI 270
gi 16262708  217 lk------rtlALSSVnsINWCRVMTQTVHYFYSYYRAver-----vgdPVVFSVPSGAFGNLFAGYLARSMGLPVARFV 285
gi 21674845  204 lr------qklTLTSAnsINISRLIPQSFYYAWAALQLrqrk----pdaLPIFSVPSGNYGNLTAGVMAKMMGFPIGHFI 273
gi 23465602  213 laerlagnshvVLSSAnsINVGRLVPQVVYYFSAYAQLladqv-invgdEVEFVVPTGNFGDILAGYYAKLLGLPVKHLV 291
gi 24378595  212 lrtk-llehgaQFSSAnsMNVGRLVPQVVYYVYAYAQLlksgd-ikngdRVNFTVPTGNFGNILAAYYARQIGVPIGKLI 289
gi 29347811  205 ln------ehlSLTSAnsINVARFLPQAFYYFYAYAQLkrag----kadNAVICVPSGNFGNITAGLFGKKMGLPVKRFI 274
gi 62511212  453 ftgfltveygtILSSAnsINWGRLLPQVVYHASAYLDLvsqgf-isfgsPVDVCIPTGNFGNILAAVYAKMMGIPIRKFI 531
gi 82180385  211 fv------kkhNIMSTnsVNWARILVQIAHFFYGYMQCaplt----eltPVEIIVPTGGAGNITAGCIAQAMGLPIHLVA 280
gi 123898412 211 lv------qrhRLMSLnsVNWSRIMVQTAHFLFAYLQLtpslpegdtlpVLEVLVPTGGAGNITAGIIVKRMGVPLRLVA 284
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1KL7_A       300 IATNENDILDRFLKsGLYERsd-kVAATLSPAXDILiSSNFERLLWYLAreylangddlkageivnnwfqelktngkfqv 378
1VB3_A       271 AATNVNDTVPRFLHdGQWSPk--aTQATLSNAMDVSqPNNWPRVEELFRrkiw--------------------------- 321
gi 16262708  286 CANNVNNALHTAFSrGVLPRh--dLVQTPSSAIDIVaPYNFWRLLYFATnrdtarirqwmkdfaar---------revvl 354
gi 21674845  274 AASNANDSVTRYLDeGRYEPk--pTVRTLTTAMDVGnPSNFARLRYFFEndfrk-------------------------- 325
gi 23465602  292 VASDKNNVLFDFLTtGTYNRqr-pFFQTISPSMDILiSSNLERMLYYLSegdtrlismlmndlnkw---------gtyei 361
gi 24378595  290 CASNENNVLTDFFKtGTYDKkr-eFRVTTSPSMDILvSSNLERLIFHLLgndsvktkelmqalie----------kgeyt 358
gi 29347811  275 AANNRNDIFYQYLQtGKYNPr--pSVATIANAMDVGdPSNFARVLDLYGgshad-------------------------- 326
gi 62511212  532 CASNQNHVLTDFIKtGHYDLrerkLAQTFSPSIDILkSSNLERHLHLMAnkdgqlmtelfnrlesq---------hhfqi 602
gi 82180385  281 VVNRNDIVHRTVQY-GDFSLg--dTKATLASAMDIQePYNMERILWLLAgsekshikemmkefqek---------krvkl 348
gi 123898412 285 MVNANDIVHRTVQS-GDFSMss-sVTQTLAPAIDIQdPYNMERVFWLLSggdglmvkslmeefqkt---------hklsl 353
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1KL7_A       379 dksiiegaskdFTSERVSNEETSETIKKIYessvnpkhYILDPHTAVGVCATERLiakdndksiQYISLSTAHPAKFADA 458
1VB3_A       322 -------qlkeLGYAAVDDETTQQTMRELKel-----gYTSEPHAAVAYRALRDQlnp----geYGLFLGTAHPAKFKES 385
gi 16262708  355 dvettktiqggFISASISDEETLATVRSVYeae---ghYLIDPHTAVAVAAVEAVrdsl-paaaAIVCFATAHPAKFPDV 430
gi 21674845  326 -------mgqeITGIAVSDAETLETIRSVYek----ygYVMDPHTAVGYRALDRFrqdhagagtPGVVLSTAHPVKFDEA 394
gi 23465602  362 peellakirqiFGTGWADEDQVRESIKHCWde----hhYVIDPHTACGYYLLEQMprd---pltPRVLLSTASPYKFPRV 434
gi 24378595  359 lekadkaildlFAAGFATEEETAAEIKRVYta----srYIEDPHTAVASAVYHAYrkss-gdqsPTVIASTASPYKFPRV 433
gi 29347811  327 -------isaeISGTTYTDEQIRETVKETWke----hhYLLDPHGACGYRALQEGlkq----geTGVFLETAHPAKFLET 391
gi 62511212  603 ekalveklqqdFVADWCSEGECLAAINSTYnt----sgYILDPHTAVAKVVADRVqdk----tcPVIISSTAHYSKFAPA 674
gi 82180385  349 peqlhkkiagaMTSCVVTDENILGTIGRCWee----nhYLLCPHSAVAVYYHYQQmdsn--dksPRCCLAPASAAKFQDV 422
gi 123898412 354 paslhqqlsevLSSGSVSDDGILEAMRRCWqd----nhYLICPHTAVAVWRHYQSpvr---pgeSRCCIATASPHKFQQA 426
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
Feature 1                                                                         
1KL7_A       459 VNNALsgfsnys------------fekdvlpEELKKLst-lKKKLKFIera------dveLVKNA 504
1VB3_A       386 VEAILgetl-------------------dlpKELAERad-lPLLSHNLpadfa---alrkLMMNH 427
gi 16262708  431 IKRALdveelpa------------aghhpviDEARDAcehlRICQLENlrsn-----ligEMTRQ 478
gi 21674845  395 IKEATgnev-------------------plpETMEEIms-kPKKATLIgnrye---elarFLSEL 436
gi 23465602  435 VNEALgfdatgtdfecm--dvlahetgttapAALRGLet-aDVRFKDVva--------idGMEDY 488
gi 24378595  434 VVSAVggkdpkddfaav--relsrlsgvsvpRAVDGLet-aEVRHRKVva--------taDMQKA 487
gi 29347811  392 VESIIgeav-------------------eipAKLQEFmk-gEKKSLQMtkefa---dfkkYLLSV 433
gi 62511212  675 IMQALkikeinetsssqlyllgsynalpplhEALLER----TKQQEKMeyqvc--aadmnVLKSH 733
gi 82180385  423 IIKANltp--------------------dipQEIKDLek-kKTRSHHLtkeddwekvlrqTIESI 466
gi 123898412 427 VQRAGltl--------------------elpESLQVLdq-lETRCADLkcsd----dweeTLRRH 466

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