Conserved Protein Domain Family
CBS_like
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cd01561: CBS_like 
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CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.
Links
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Statistics
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PSSM-Id: 107204
View PSSM: cd01561
Aligned: 90 rows
Threshold Bit Score: 231.249
Threshold Setting Gi: 71041836
Created: 1-Aug-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1JBQ_A; catalytic residue (lys) and cofactor (PLP)
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                            #                                          
1JBQ_A      107 GDTPMVRInkigkk---fglkceLLAKCEFFNAgGSVKDRISLRMIEDAERDgtlk-pgdtIIEPTsGNTGIGLALAAAv 182
gi 20804032   4 DRTPLPFSqysaaya--lpriirCGSNLYLAQF-AFMKLLPAKYIIGQAVARgtlt-hdtiVLETSsGTFALGLAVVCRe 79
gi 21219509   1 MIHPHIADalkvp------dlvrLNDDLVLIRF-ESMKIYSALAAVRHLLERgtir-pgqtLIDSSsGIYAYALALACHr 72
gi 21685476  12 GNTPLVQLqldss------argnVFAKLEMLNP-FGMKDRAAKKVILEAKKNgvlk-dgapIIESSsGTMALGLAMVGTy 83
gi 25027974  43 GNTPLVRLdrltr-----drdftLWAKLEYFNPgGSAKDRTAQAMVTAGTLKpg-----dmVVESSsGNLGIALAREAVl 112
gi 28870138   9 GYQSLGDIvhdqtflevtgvgpdFFLKMESLNPaGSIKLKTAVGLVNDVQARgllg-pqttLIESSsGNLGVALAMICAe 87
gi 29830191  14 GNTPLVELerllp-----dfgsrVFGKIERFNPgGSIKDRSALGMLLAGIRSgevqpgrtvIIESSsGNLAVGLAQICRy 88
gi 29833704  10 FNEEELYVdlrsi------fghsLFLKCEGFNFaGSIKLKAATEMVEAAERDgvlt-pesiLVESSsGNLGVALSMIAAs 82
gi 32473073  24 GGTPLVRLnrfld-----rpdieLIVKWEAANPgGSAKDRPAAKMLSEALKRgeig-pettIVESTsGNMGIGLAQVCRy 97
gi 32967977   5 PVTPVRTVrteia-----giprtITLKLEGHSPwRSVKGRTALSLIRSVAGDltap--datVVESTsGNLGLALSAICRd 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1JBQ_A      183 rGYRCIIVMPEkmSSEKVDVLRALGAEIVRTptnarf--dspesHVGVAWRLKNeipnSHILDQYRNASNPLAHYdTTAD 260
gi 20804032  80 yGFSLEIFTDPvmDKGLENRLRSLGAEVFIItekakeggyqrsrLDAMHARMRQlgesHFWPRQYETPDNPAAYR-CFAD 158
gi 21219509  73 yGMRCHVVASTtvDTTTRAQLEILGATVEQVrpsrnl-kldqelRVRRVREILAdhpdWHWMRQYHDDVHYLGYQ-EVAD 150
gi 21685476  84 lGHPVHIVTDKrtDQMTLAKLKSLGCKLEIVtemthl--gwqsaRLDRLEEILKenkeAFCPRQYENSDNPNAYE-SLAD 160
gi 25027974 113 gDWTFHCVVDPraNRSTVKHMQALGAVVHQItepdeetgdwlvaRRKRVAQLLQeipeAICLDQYSNTEAFRAHQeGTMA 192
gi 28870138  88 rGIPFTCVVDPnsSSHNIRMMRSYGAQVIQVeipdan-ggflgtRIALIREKVAsdprYVWLNQYENAANPRAHArTTAH 166
gi 29830191  89 fGLRFICVVDGktTEQNLAILSAFRAEVEVVterdeltgeflpvRLRRVRELVAatpdAYWPNQYASLLNPKAHE-TTMR 167
gi 29833704  83 kGYRFLCVTDSrgNLSTRMMMEALGSEVHMIagqean-ggflgaRIAYVRALCAsddrYVWLSQYTNPSNWKAHYrKTAP 161
gi 32473073  98 hGLKFICVVDPraQKQNLSIIEALGGTIELVtqplkg--dflaaRIAKVCELIEttpnSYWPNQYANTDNPRSHFkGTIR 175
gi 32967977  78 lGLRFIAVVDHrqSPVIQQAIEANGGELDWVrtpdda-tthlqdRLARVRELERdlphAVWPNQYENDANWRIHEtWTAP 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1JBQ_A      261 EILQQCdgkLDMLVASVGTGGTITGIARKLKEkcpgCRIIGVDPegsilaepeelnqteqtTYEVEGIGydfIPTVLDrt 340
gi 20804032 159 QISELLg-aDVTLVGSVGSGGSTCGTIERLRQkalgARLIGVDTfnsvif------gqldgERKLRGLGnslVPKNVKhe 231
gi 21219509 151 RITTAFpstPLTVVGGVGSGASTGGLVERLRAtdpsVRLVGVQPfgsvtfg---sqahhdpEAIIAGIGssiVFDNVRhh 227
gi 21685476 161 EALEELg-hIDILVASVGSGGSLCGTARALKKanpdLRVVAVDAvgsvif-----nqpdipGRLQGGHGnsvIPKNVDfs 234
gi 25027974 193 EIVQQLghaPDHLLVAVSTTGTIGGCLRHIEAhhlpTQVTAVDAmgsvlf------dgnpgPRHLPGFGagmVPELSRqi 266
gi 28870138 167 SISRHFg-hVDYLFVGAGTTGTLMGCLQHFQRhhptTKIIAVDSvgsvtf------gtpasRRFIPGLGtsqRPPIFNgd 239
gi 29830191 168 EIEESLdgaVDFLFCSVSTFGTLRGCRDHIRArgldTTIVAVDAlgsaif------glestQRLIPGHGasvVPPLMDas 241
gi 29833704 162 EIARQFp-rLDVLFVGAGTTGTLMGCARYFREwhrpVRIVAVDSvgsvsf------ggppgRRMIPGLGmsmRPPLLDes 234
gi 32473073 176 EIDETLngeFDVLFVATSSTGTAQGCRDFLKSrgrdVQVVAVDSvgsvlf------ggssgPRKIPGLGagkEPRLAAgq 249
gi 32967977 157 EFDAQVthrAQALFAGVSTGGTLAGLSRHFRRtrpgLRIVAVDVrgstvf------ggvprPRTLTGIGagrRSAFLTra 230

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                                                                         
1JBQ_A      341 vvDKWFKSNDEEAFTFARMLIAQeGLLCGGSAGSTVAVAVKAAqelq-egqRCVVILPDSVRNYMT 405
gi 20804032 232 lyDEVHFTSASLAFAATQALHERhAIFAGPTSGASYIVGRWRArqh--peeTVVVICPDEGHRYAE 295
gi 21219509 228 lyDAVHWLDFTHAMSGTIALLRErAVFAGLSTGAGYLAATYEArrh--pdrLHLVIGADTGHRYVE 291
gi 21685476 235 iiDEVHWLNDEECYAANLELAKCeKLFAGNSSAASYAVSRFLSsrcs-eetNILTIFPDRGDRYYK 299
gi 25027974 267 tpHRVLRVADRESVEGARTLVRKeTILPGASGGAVIAAVDKLKdvfe-sgsDVVVILHDSGTRYMD 331
gi 28870138 240 giHALEMVPEANAVAMCRILARSkGMLVGGSTATVIAAVHAWRerie-pgsVVVALSPDWGERYLD 304
gi 29830191 242 aaDEVVHISDLECVVACRRLIGReAVLAGGSSGATVAALWKIRhrip-egsNCVLIFPDGGDRYLD 306
gi 29833704 235 yvDEVIRVEEADTIRTCHRLARR-GFLFGGSTGTVVSGATDWLaghdarelTAVAVGPDLGERYLD 299
gi 32473073 250 sfDHLVRVSDLECVVGCRRAAQReAMLIGGSAGGVLMSVGRMQeqf--agkRCVAVLHDSGTRYLE 313
gi 32967977 231 stDDVLLVDERQAVACCHTLRADtGTAVGGSSGAVLAGCLEYLyrhp-evrHALCLCPDLGDHYGP 295

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