Conserved Protein Domain Family
Thr-dehyd

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cd01562: Thr-dehyd 
Click on image for an interactive view with Cn3D
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.
Statistics
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PSSM-Id: 107205
View PSSM: cd01562
Aligned: 74 rows
Threshold Bit Score: 277.446
Threshold Setting Gi: 27376524
Created: 1-Aug-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1TDJ_A; catalytic residue (lys) and cofactor (PLP)
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                       #                               
1TDJ_A       17 LRAVLRAPVYea--aqVTPLQKMEKLssrl-dnvILVKREDRQPvHSFKLRGAYAMMAGLTeeq---kahGVITASAGNH 90
gi 15596048   5 LAALQQAAAIvhqslpPTPQIRWPLLceal-gceVWMKHENHLPvGAFKLRGGLVYFHHLAhqge--rpaAVISATRGNH 81
gi 17537387  41 FGDISMAHHRiqngivRTDCRKSRCLsklf-dmnIYLKMEVNQDtGSFKERGARYALQNLPeek---kkaGVYAASAGNH 116
gi 17545667  16 LRRLRAAAAVvnavipPTPQYCWPLLsqal-gaaVWVKHENHTEvGAFKVRGGLNYLHALRrrdp--elrGVIAATRGNH 92
gi 19552203   4 LNDVITAQQRtaphvrRTPLFEADPIdg----tqIWIKAEFLQKcGVFKTRGAFNRQLAASenglldptvGIVAASGGNA 79
gi 21225568   4 ITEIEAAAERiaghvvRTPTVPSPGLsall-gvpVTAKLELLQRtGSFKARGATAKLLSLTeae---raaGVVAVSGGNH 79
gi 21355833  61 FHDVTSAAFLirggveRTPCPKSTSSdly--gmeLYLKKDFLQYtGSFKERGARYALLSLTeeq---krtGVISASLGNH 135
gi 27372182  12 LSAIAGLRARlkqwvrTTPVFDKTDFepvp-gtaVNFKLELLQAsGTFKARGAFSNLLALDddq---raaGVTCVSAGNH 87
gi 27376524  21 RERIAATEVVirphirRTPLVMADLAdfglpaapITFKLEMLQHsGSFKARGAFANLLLRPvp-----eaGVVAASGGNH 95
gi 47221699 126 FEDISAAAFRiqtgiqKTPCTYSRLSkqy--gmeIYLKKEQLHYtGSVKERGVLYLLTCLTqeq---qrkGVIVSTDCNF 200
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1TDJ_A       91 AQGVAFSSArlGVKALIVMPtatadIKVDAVRGFGGEVLLHganfdeAKAKAIELSQqqgFTWVPpfdhPMVIAGQGTLA 170
gi 15596048  82 GQSVAFSASryGIQPIIVVPhgnsrEKNAAMRSLGAELIEHgedfqaSREYAAERARr-eGLHLIpafhPWLVAGVASYS 160
gi 17537387 117 ALALSLHGKqlGVEVNVVMPkiaplMKINRCQDLGANILVQgediaeSREIALRMAHdsnGTYINgydhYDILAGAGTTG 196
gi 17545667  93 GQSIALAARkqGMSATIVVPhgnsvEKNAAMRALGAELVEAgedfqaSREAAARQAAe-rGLHLVpafhEDLVAGVASYW 171
gi 19552203  80 GLANAFAAAslSVPATVLVPetapqVKVDRLKQYGATVQQIgseyaeAFEAAQTFESetgALFCHaydqPDIAAGAGVIG 159
gi 21225568  80 GIAVAVMAAalDVKATVVMPrtapaRSVEIAEEAGALVRLTdgm-dsAFALVTRLREe-gLTLVHpfddPVVVAGQGTVG 157
gi 21355833 136 AQALCYHGWklNIPVTVVMPkaapiMKIQKCRNYKARVIVDgndmgeAKSLAMRMSReegLLYVNgydhPHIMAGQGTIG 215
gi 27372182  88 AVGVAYAAMrlGIPAKVVMIktaspARVALCRQYGAEVVLAeng-qtAFDTVHRIESeegRFFVHpfngYRTVLGTATLG 166
gi 27376524  96 GAAVAYAAQrlGIPATIFVPditspAKAERIKGNGAKLVIAgsryadALAASEAHVArtgAMAVHaydqAETLLGQGSVA 175
gi 47221699 201 SMAVAHHAVelKIPVFAIMPsscssPRLRIYRDYGAMVISYgstghdSRNHARHLAKengYLYLEedesEAYLAGLGTVG 280
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1TDJ_A      171 LELLQQDah-lDRVFVPVGGGGLAAGVAVLIKQlmpQIKVIAVEAeDSACLKAALDAGHPVDlprv---glfAEGVAVKR 246
gi 15596048 161 LELFAALad-lDEVYVPIGMGSGICGLIAARDAlglKTRIVGVVSaHAPAYALSFEAGTAIShpvd---trlADGMACST 236
gi 17537387 197 IEILEQIqm-pDAILVPVGGGGLVAGVATAVKAlspTTEVIGVVSeTCQAIVKSLQAGHPVYtptr---ptlADGLAVPN 272
gi 17545667 172 LEFFEEAap-lDVVYVPIGMGSGICAAAAARDAfrlSTRIIGVVSaHARCYDYSFNCGAPISapvs---tqlADGLACRT 247
gi 19552203 160 LEIVEDLpd-vDTIVVAVGGGGLYAGIAAVVAAh--DIKVVAVEPsKIPTLHNSLIAGQPVDvnvs---giaADSLGARQ 233
gi 21225568 158 LEFAEDAsd-lTDVLVSIGGGGLIAGVAAALRAlrpGVRVWGVETeGAEAMSRALAAGGPLTvpl----ssvVTTLSAPS 232
gi 21355833 216 LEILEQVpe-pDAVVVPVGGGGLIAGIATAVKAlspKTKIIGVESeKCASFTRAMENDGPIHtpik---ntlADGLAVPK 291
gi 27372182 167 HEWLEQAga-lDAVIVPIGGGGLMAGVSTAVKLlapQCQVIGVEPeGADAMHRSFETGGPVKmgsm---qsiADSLMAPH 242
gi 27376524 176 LELEQDApg-iDTLLVAVGGGGLIGGIAAWYAG---RTRVVAIEPeQSPTLHAAIAAGAPVDapag---glaADSLAPRR 248
gi 47221699 281 MEIFEQVpkvdAVVLPAAGQYGLLAGTAAAIKHlnsQITVIGVEPeGFPLLLQSLKTDSPVKdvhsnpnkqlYGDLMERS 360
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1                                                                                 
1TDJ_A      247 IGDETFRLCqeyldDIITVDsDAICAAMKDLFEDvRAVAEPSGALALAGMKKYIalhnirgeRLAHILSGANVN 320
gi 15596048 237 PDPSALEMIlagadRLVRVSdREIGAAMRLCFTStHNVAEGAGVAALAAAWQERerl--kglKVGLILSGANVD 308
gi 17537387 273 AGVNAFASMigkvdRVISVPeNDIAVAILRLIENeKVVCEGAGAIGIGAILSGKlnhl-kgkTVVSILSGGNID 345
gi 17545667 248 PDATALEVIragvdEIVTVTdDEVAEAIRLYFSTtHNIAEGAAAAALAAAWQQRdql--aglRVGLPLTGGNID 319
gi 19552203 234 IGREAFDIAtahppIGVLVDdEAIIAARRHLWDNyRIPAEHGAAAALASLTSGAykpa-adeKVAVIVCGANTD 306
gi 21225568 233 VSRLTYDHVaelvtEVLVVPdREAVRGSLALAEHaKVWTEPAAGCLLPAARRVVervg-dgaRIGLVVCGGNAT 305
gi 21355833 292 VGYNAYATAmplidRMVVVKeEWIAVAILRLVEEeKCVVEGAGGAGLAAILAGHldel-kgkKVVVLLCGGNID 364
gi 27372182 243 TEQYSYELCrrnvdRLVKVSdDELRAAMRLLFDQlKLATEPACATATAALVGGLkael-agkRVGVLLCGTNTD 315
gi 27376524 249 VGELMFPIAqahveRVVLVSdEAIRQAQAALWSSlRLVAEPGGAAAFAALLSGRyrps-pgeRVAVLLCGANTT 321
gi 47221699 361 LGVNVFQLTkklvdKVISVSeEDSLVAMLRFQEFeRSTVDTEGAMGLAAILAGQlpel-kgrKVVVVVSSANME 433

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