Conserved Protein Domain Family
CIDE_N

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cd01615: CIDE_N 
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CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of ICAD/DFF45, and the CAD/DFF40 and CIDE nucleases during apoptosis. The CIDE-N domain is also found in the FSP27/CIDE-C protein.
Statistics
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PSSM-Id: 119367
View PSSM: cd01615
Aligned: 38 rows
Threshold Bit Score: 97.6086
Threshold Setting Gi: 156553604
Created: 12-Dec-2003
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:putative heterodimer interaction sites [polypeptide binding site]
Evidence:
  • Comment:Although the CAD and ICAD CIDE-N domains are structurally similar, they bind one another asymetrically using different surfaces from each protein.
  • Structure:1IBX_A; Homo sapiens DFF40 (CAD) and DFF45 (ICAD) form a heterodimer.
    View structure with Cn3D
  • Structure:1F2R_I; the CIDE-N domain of mouse ICAD binds to the CIDE-N domain of CAD, contacts at 4 A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #        ## ##         #   #                # ##    ##                  # #
1IBX_A         4 KPKSVKLRALRSPRKFGVAGRSCQEVLRKGCLRFqlp--erGSRLCLYEDGTEl-tEDYFPSVPDNAELVLLTLGQAWQG 80
1F2R_I        17 PLKPCLLRRNHSRDQHGVAASSLEELRSKACELLaidksltPITLVLAEDGTIvddDDYFLCLPSNTKFVALACNEKWTY 96
gi 45383564    4 PLRGFRLRRPGSAQKFGAAAGSLRGLLRKGCRLLqlp--laGSRLCLYEDGTEl-sEAFFRTLPPQTELVLLRPGESWPG 80
gi 35903034    6 KPKLVKIRSANQARKYGIAAVNLKELIKKGCQLLkvs--ssGVLVCLYEDGTVv-tEEYFQNLPDNTDLVLLPHGQSWNG 82
gi 47222792    4 KEKPVKIRSYNSSNKYGVTAKNVKELLDKGCKLLkvp--paGARICLYSDGTEf-tEKYFHTLPAHTELVLLSRGQSWSG 80
gi 187608292  11 KIRCYKIRTLHSQQKYGIACKNLAELKQKACRKFqld--cpTTCVCLYEDGTEv-sEEYLETVPDNTVLLLLTPGQTWQG 87
gi 50759301    4 RLKPCVVRRGDGREQHGLAASSLRELRDKAGSALaigedgrPITLVLAEDGTIvddEDYFLCLPSNTKFVALAEGERWSG 83
gi 60416006   19 FQKACVVSLPGSKDRHGVAAASLEELLEKACKKFsldssvePITLVLAEDGTIvedEDYFLCLPPNTKFVILTGNKKWAP 98
gi 47228821    4 DKKPCRVCNFTRQKSYGVAVPSLMELKTKGSEFLgfr-ssdPVTVVLEDDGTIvadESYFLCLPPNTKFMLLHEKEMWAP 82
gi 110772194  11 LGNPYKIVDHTREKRKGITASSLKELISIARNRLslp-ldaEVTIVLEQDGTEvddEEYFATLERNTSLMVLYGNQKWVA 89

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