1W25,3BRE,3EZU,2V0N


Conserved Protein Domain Family
GGDEF

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cd01949: GGDEF 
Click on image for an interactive view with Cn3D
Diguanylate-cyclase (DGC) or GGDEF domain
Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.
Statistics
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PSSM-Id: 143635
View PSSM: cd01949
Aligned: 825 rows
Threshold Bit Score: 80.2932
Threshold Setting Gi: 207084904
Created: 13-Dec-2003
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:the active site is formed at the diguanylate cyclase dimerization interface
  • Structure:1W25: Response regulator PleD in complex with Cyclic Di-GMP
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                      #  ##    #   #                     
1W25_A        289 VTDQLTGLHNRRYMTGQLDSlvkra---tlggdPVSALLIDIDFFKKINDTF-GHDIGDEVLREFALRLASNVra----i 360
gi 42525647   361 AKSNLQGEANFTLNSTTLTQkidniiinmnadeEVYLLYLDIDKFKTINQLW-GYYAGNALIQHIYSMILAHIksfnipe 439
gi 15606615   641 THNVETGLLNKVGFQKVLSPllgk------lssTGALIALDMVGFSRLIKEF-GEEAIKKLLKEIAVRLEKTFrr----g 709
gi 207086194  236 YIDKATKLRNRKYLIDKLPEylkid----atskGGINMMIALSGIIEANEKI-GHQQVDKFFLAIANIFDAHAsny--dn 308
gi 207085546  185 IFDNKFGVYNKRYLMTKIEQevel-----itefKHKSSLIMIELSRELKDSVsNEKAITLMTRTIARLLLKTSrr----s 255
gi 91201123   944 LIDELTMIFNHRYFQIRLVQetlra---erynlPLALILFDIDHFDNYVARK-GEYYGNLVIKKTSGLVKKNTrg----s 1015
gi 207085309  154 SVDALTKASNKMHMTSIIKTnlkkir--dgqikSFSLMYIDVDDFNAFIRAN-GINATDATIKKIAMIIKRSIrd----k 226
gi 91201830   587 VMDEFQGIYNKRYFTELLTKqlava---krrdeNLSLLILGPDNHKATTETYgSNNAGNLLLQQIAGVLSDSVsn----s 659
gi 39996771   154 RIDTLTGVYNRRYLDERLSPeikra---yryerALSLILVGINDFSGITSAH-GHYAGELALKGCADVLAESIrr---di 226
gi 196195125   95 REDHLTGLFNRPHLLGMLERelals---qrhnyTVSILLIEIEDFTQLLDSY-GRHTGEKALRLFADCIREKIre----s 166
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             # ####                                                                      
1W25_A        361 DLPCRYGGEEFVVIMPd-tALADALRIAERIRMHVSgspftva----hgremlnVTISIGVSATage----gdtPEALLK 431
gi 42525647   440 DSFMHVIGDEFSIFYFg--NEEEVCRFTQTLIDKINseyftw------nekkltISISVGIVNIpki----pqsSQEIIS 507
gi 15606615   710 DIIAKGDGDEFLIFAYplkKKDDVLSLIEKIRQKFSkpltid-------gkkirLSFYIGVVTYpyd----grtFSELYY 778
gi 207086194  309 SIVARMNGTEFSILLPd-cSDKEGINLAKGIYSSCKkiakgf------nldsseTFISLGLYSYnyk-----enIGQLLS 376
gi 207085546  256 DTVAHYGNGVFAMLLKh-tDIPSALKASERLCELVSnsnffl------adreiqLKISIGITDIatl-----ytVEEIVV 323
gi 91201123  1016 DIFIRYGNSTFALLLTn-tIMSSATNLAKRFVSTIHdypflye----evqpmgkITISLGLVEFka------qsPEEFVY 1084
gi 207085309  227 DILAHWHGDKFMISFAq-iSKDELDDTAKAIRDKISkapfg---------lnghLTCSISIVEItsd-----enINTIID 291
gi 91201830   660 DIIARYDKAEFAIIMPa-tFATRALVKADGIRQRVEytgfhdp----asgnqvnITISIGISSFpeh----aseVEPLVT 730
gi 39996771   227 DWLARYDDDRFVVVLPe-tDASGAMILAKRLRIRIAsmalkl------ydkeikVNAAFGVAGFtatqqkegmtPHILLD 299
gi 196195125  167 DLFGRFDGAQFLLVLPh-tNFDDAARMGEGLKALAGnlklsspgtaaqpeeavtVCARIGVASTens----grsLNPLLN 241
                         170
                  ....*....|....*...
Feature 1                           
1W25_A        432 RADEGVYQAKasgrNAVV 449
gi 42525647   508 NAYDACSIAFrkggGCYE 525
gi 15606615   779 RAITAVKEAKrrgaGEVV 796
gi 207086194  377 HSDNALAQAKfsedNIYL 394
gi 207085546  324 SAMDGIEKAYsdkkIDFA 341
gi 91201123  1085 AAEFSLSAAAakgrNRVE 1102
gi 207085309  292 KLQNSIKLSKetnkGSIV 309
gi 91201830   731 LANKAFYKAKndggNRVE 748
gi 39996771   300 KADRSLREALeeggEMIK 317
gi 196195125  242 EADYALYQNRnegrEKTS 259

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