Conserved Protein Domain Family
P-type_ATPase_Mg

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cd02077: P-type_ATPase_Mg 
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA
MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.
Statistics
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PSSM-Id: 319772
View PSSM: cd02077
Aligned: 20 rows
Threshold Bit Score: 965.173
Threshold Setting Gi: 42561425
Created: 6-Dec-2004
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Feature 1: P-type ATPase signature motif, 7 residue positions
Conserved feature residue pattern:D K [TS] G T [LIVM] [TS]Click to see conserved feature residue pattern help
Evidence:
  • Comment:a characteristic P-type ATPase conserved sequence motif: DK[TS]GT[LIVM][TS], in which D is the reversibly phosphorylated Asp

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 20141214   49 GLTIEEASERLKVYGRNevaheqvppaliqllqaFNNPFIYVLMALAGVSFITdywlpl-----rrgeetDLTGVLIILT 123
gi 110005412  51 GLTYDEAEEMGKKYGDNsqekmkfh-wfkhflkvLLNPFNIVLALIATYNIISyfalg--------gdsfEVIGVIIIAI 121
gi 42561387   50 GLTNEQYESRLKKYGTNelkkkrfn-liaeflhaFFGPFNIVLLLISLYNFISyatngfyqdtsssdskfELVGALIILV 128
gi 52842590   28 GLNNFQAQKRLTQYGTNeilrkpyhliileaishSINPLVAILFFAALISAFTg----------------NVVNAAIIIS 91
gi 50365313   36 GLNDEQVEVNREKFGGKelkparfn-vflvfvksFFSPFNIILMAIDAFNFYEyvsd---------pntfSLVAAVIVLI 105
gi 58336553   37 GLSTKKAEENRREYGKNeirtntnaskwrllwesIATPFTVVLLVLTLLTIFTsyilv-------pqgnnDIDTILVMVI 109
gi 42632642   36 GLDQKQVMLHQSLYGKNilsqetktsftkqllqiAITPFNIVLLILTLISLFNdvltp-------sqenrSYSTVITTIL 108
gi 27382164   30 GLTATEAAERLGRFGPNsdappriegaaravlrrLLEPLSLILLVAGIVSMLTg----------------DDVGGLIIVL 93
gi 15673239   48 GLSEEQVEISREQYGDNtitrgkktslikrlyqaFINPFTIILFVLALVSAFTdiila-------apgekNPQGLIIITT 120
gi 21673463   52 GLDSQEASKRLSKYGKNeislatrpsflqdilhrLSSPLVIQLVLIAVVSGVTg----------------DMTSSAIVGM 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 20141214  124 MVSLSGLLRFWQEFRTNRAAQALKKMVRTTATVLRrgpgn---------------igavqEEIPIe-------------- 174
gi 110005412 122 MIIISATIAYVQDIRSFFVTKKLTDLVSNTITVIRledd------------------ekvSEVSVknntslireakelei 183
gi 42561387  129 MVLASGLASFIQSLRSHLVTKKISSIVKSTTNIIRhkndedvedylkitkrnqldlirlgEEIDVk-------------- 194
gi 52842590   92 IIIISIGLDYFQSHRALVAIKMLQKKIATTVTVLRen---------------------qwLEIPAk-------------- 136
gi 50365313  106 MILASGTMAFIQEIRSHLVIKRMITENKKTSKVIRnis-------------------ynyKSVDNansirmikeaevien 166
gi 58336553  110 MLIISVGVNFAQKIRIAKVTEKILEMVSVTTNIRRdg---------------------knVELPTd-------------- 154
gi 42632642  109 MFLGSVIVQFSQESKHLKITSQLKTLVQNTTAVKRnn---------------------fkMEIALe-------------- 153
gi 27382164   94 ILAGSIGLDTIQEGHAVRAAEILRRSVALKAEVRRdg---------------------afCEIDVd-------------- 138
gi 15673239  121 MVLISGILRFVQETRSGNAAENLLKMITTTTNVHRles--------------------gsQEIPIe-------------- 166
gi 21673463  116 MILLSVGTSYVLERRSGNAVEALGKRVQSRAHVIRng---------------------leAEVPLs-------------- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 20141214  175 -eLVPGDVVFLAAGDLVPADVRLLASRDLFISQSiLSGESLPVEKydvmadvagkdseqlpdkdkslldlgNICLMGTNV 253
gi 110005412 184 heLVPGDLIYLSSGDMVPADVRILWSNELFINQSsLTGESLPVEKhasynrhk-----------aslleleNICYTGTSV 252
gi 42561387  195 -qLVPGDLIYLSSGDMLPADVRIIQSTDLFINQSsLTGESIPVEKhannkknt-----------nnildleNICYTGTSV 262
gi 52842590  137 -eLVPGDLFRLSAGDMVPADSILLKSKDLHIHQAaLTGESMPVEKeaiplktk----------pknpldalNIVFSGSSV 205
gi 50365313  167 deLVPGDVIYLVNGDIIPADVRIIWSNNLYVNQSsLTGESFPVQKkdshdkef-----------eshlsyeNIGYMGTEV 235
gi 58336553  155 -eVVVGDVINLSAGDMIPADMKLLTSKDLFCSSSyLDGDSEPVEKvanvslkps--------mladylnypNILYEGMTV 225
gi 42632642  154 -eVVRGDIVILSAGDVIPADIKLLETKDFFVKTTtFTGESEPVEKmacsflqs-----------etilddpKLVLAGSTV 221
gi 27382164  139 -hVVPGDLLRVRAGDIIPADGLILESTAFTAGEAaLTGEPYPVQKragaat--------------dpddtsNALFRGAVA 203
gi 15673239  167 -eVLVGDIIHLSAGDMVPADLRIIQAKDLFISQAsLTGESEPVEKldlatdek----------ddsitesvNLAFMGSNV 235
gi 21673463  161 -eLVPGDIVQLQAGSVIPADLRLISAKDFFVGQAaLTGETMPVEKsadagetg----------nlgilelrNACFQGSSV 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 20141214  254 TSGRAQAVVVATGsrTWFGSLAKSIVGTrt-qTAFDRGVNSVSWLLIRFMLIMVPVVLLINGFSKg-------------d 319
gi 110005412 253 VSGSAIAVVIGVGpeTYYATISKTLQAKpp-eNSFNRGIKRTTWLLLSFMFVMVPIVFVINGITKn-------------d 318
gi 42561387  263 VSGSALAVVLATAndTYFSTISKAILEKrp-dSSFTKGIKQVTRMLLIFMLAMVPTVYLAKSIIGtissggsfdsikdnp 341
gi 52842590  206 IGGSATALAINTGsnSLFGHIAESLKKKpp-hTEFEQGMMRFSTFIMKMVFLLVIFVFSINIYMHr-------------p 271
gi 50365313  236 MSGSGLAIVVATGqkTYFSLIDNKVKEKrk-sSSFEKGIKRITLYLIAFMIAVIPVVLLISGLQQg-------------d 301
gi 58336553  226 VSGSGSAIVFAVGnnTVFGKKVQHIFRKkvkvTLFDREIKQLAKILIVAAAILVPVLFLINGVTKg-------------n 292
gi 42632642  222 ISGYATGIVLVTGkdTYLGNISQEITKKks-lSHLDQSINTIAKLLMICICLMAPLVFLFNFYKPqn------------t 288
gi 27382164  204 QTGEAIALVVRTGrdTVFGAAASALAETqa-pSPFERDLREFGLVIARATLALVLVVLTVRVVFGr-------------p 269
gi 15673239  236 ISGSAYGVVIATGdaTIFGEMAKSVTEDst-kTTFEKGVNSVSWVLIRFMLVMVPFVLLINGFTKg-------------d 301
gi 21673463  230 SSGSARAVVVNTGsrTFFGAIAERLNQRrd-eTDFDKGIRSFTWLMIRFMVVMVSTVFLIVGLTKg-------------n 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                    #######             
gi 20141214  320 WVEASLFALAVAVGLTPEMLPMIVSSNLAKGAIAMSRRk-VIVKRLNAIQNFGAMDVLCTDKTGTLTQDNIFLEHHLDvs 398
gi 110005412 319 WLSALLFAISVAVGLTPEMLPMIVTSNLARGASRMSKAk-VVVKKLEAIQNLGAIDVLCTDKTGTLTNDKIELVDYQLld 397
gi 42561387  342 WFQAIFFAVAVAVGLTPEMLPMIVTTNLANGASKMSKQk-VVVKQLEAIQSLGAIDVLCTDKTGTLTNDKIELVDYLRvd 420
gi 52842590  272 LLDSLLFAVALAVGLTPELLPMITTVTLASGAVRMSKKk-VIIKNLSAVQNFGSIDILCSDKTGTLTSGEMNLTKYLDfs 350
gi 50365313  302 WVKGAMFTIAIAVGITPEMLPIIVTSNLTRGYKQIEKNgeMIVKNLNSVQNIGAIDILCTDKTGTITSGEISLDKVTGvn 381
gi 58336553  293 WGESLIFALAAAVGLTPEVLPIIVNSNLTKGAIEMAKQg-AVVKQMNAIQNIGSTDVFCIDKTGTLTQNKVVLERHYDln 371
gi 42632642  289 FLQSFLFALTIAFGLTPKMLPLIVATSFSKGIVALSKRk-VIVKNLNAISSFGAMNILFTDKTGTLTEDQIFLENFLDln 367
gi 27382164  270 VLDSLLFAVALAVGLTPELLPMITTVTLSRGALRMAGRk-VIVKRLAAIHDLGAMTVLCTDKTGTLTSAEITLARSLDae 348
gi 15673239  302 WMEAALFALAVAVGLTPEMLPMIVTTCLAKGAVTMSKEk-TIIKNLNSIQNLGSMNILCTDKTGTLTQDKVVLMRHLDih 380
gi 21673463  296 WLESLFFSLSVAVGLTPEMLPMIVTVNLAKGALSMARKk-VIVKQLSSIQNFGAIDILCTDKTGTLTQDHVLLEMAVDvm 374
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 20141214  399 gvkssrVLMLAWLNSSSQSGa-------------rNVMDRAILrfgegria-----pstkarfiKRDELPFDFVRRRVSV 460
gi 110005412 398 nkkddrLLTYLYLNSYFQTGl-------------kNPLDKAIIhyidnhhl-----ssfkddyqKIDEIPFDFNRRKLTV 459
gi 42561387  421 kkadplLLKYLYINSYYQTGl-------------kNPMDKAIVdyvnkhnh-----nfsiqditKIDEIPFDFNRRKLTI 482
gi 52842590  351 gkqsefVMLLAYLNSLYITEikspfniavlkkarlNPLDLAILkhdhpd----------iqpyhKVDEIPFDFERRRSSV 420
gi 50365313  382 geksefLENVLYLNSYFQSGf-------------qNPIDSAVLsskikkp--------dvddytKEWEIPFDFERKILSV 440
gi 58336553  372 mqekprILKFSYLNAYYQTGm-------------eDLIDKAVIdaagdelnv----neiqrdynKIDEIPFDYIRKRMSV 434
gi 42632642  368 gnedirVLRHAYLNSFFQTGl-------------kSLIDKAIItktnnaktlhpslqgitaqftKIDEIPFDFKRRKMSV 434
gi 27382164  349 gkdnarAAQLGAIAASLGGDr--------------GSLDAALVagrpda----------aqgwtLAGRQAFDFSRRLGSV 404
gi 15673239  381 gqenirVLRHGFLNSYYQTGl-------------kNLMDLAIIegaeakqdknpelgglsskytKVDEIPFDFERRRMSV 447
gi 21673463  375 geqsdnVLRYAYLNSFFQTGl-------------rNLLDRAVLdhqefa---------vdgnckLIDELPFDFQRRRMSV 432
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 20141214  461 LVEdaq---hgdRCLICKGAVEEMMMVAthlregdrvvaltetrreLLLAKTEDYNaQGFRVLLIATRkldgsgn--npt 535
gi 110005412 460 VVSgkd----khHTLICKGAIEEIIKNCtrieykgkvekiteehlrMIFATAERMNsEGLRVIGLAYNhghdad----ty 531
gi 42561387  483 IFDden----ekRFMVTKGSVEEILNSCtrviqddkvvnltdtfkrQIIAYYETINqQGKRLLGVAYKkirdnq----ak 554
gi 52842590  421 IVSkn-----enHLFICKGAPENIMSVCsyydfagerelftekeqkQCELLFQSLSsEGYRVLAIAYKlmdrql-----k 490
gi 50365313  441 ILTsk-----kdKEIFTKGAVEEVLKVCnrisingkiekldaklkkMILKKTHELNiDGYRVIGIAHNvlq--------- 506
gi 58336553  435 VVVdndd-hhgqHILVTKGAAEGMLNISskvevdgriekltsawreKILNQINELNdDGLRVLLIGYKvnpapv----ge 509
gi 42632642  435 VIQdas----qkQQMITKGAIEEILSICdhvelegkvvplsdqskqIVLQQTITYNqKGYRVVGVAQKlisnpkqqpcft 510
gi 27382164  405 LATgp-----egTLLIVKGAPEAVLALCtmde----------rartAALARVRELAsEGLRTVAIASRawsgvl----re 465
gi 15673239  448 VVKsntngatskTQMITKGAAEEMLDICtlvedkgnvvhltpelraYILKKVDELNeEGMRVILVAQKtnpspi----dt 523
gi 21673463  433 VVDye-----gdHVLISKGAVEEIFACCdryqiddeiypligmirdDLFEEVAALNnNGYRVLAIAYNefppdr----kr 503
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 20141214  536 lsveDETELTIEGMLTFLDPPKEsAGKAIAALrdnGVAVKVLTGDNpVVTARICLEVGIdthdiLTGTQVeamsdaelas 615
gi 110005412 532 ystkDEKNLIFYGFFSFLDKPKPsAAKMIQLLrknGVQLKILTGDNeQVTRAICDRVHLkirgvITGDYIeklsefelrd 611
gi 42561387  555 fspkDEESLIFMGFASFLDTPKPsTKQTIRLLkkyGVDLKILTGDSePITRAICKMVNLdikglVTGEEIdaaseyelkk 634
gi 52842590  491 ytqsDEKEMIFAGFLAFTDPLLEdIPKVIKDLrqeGINIKILSGDNlIVTQHICQTVGMdtsriLTGEEIskisddalps 570
gi 50365313  507 -dedVEEELIFYGFGTFFDKPKKtSKKLIKNLaskGISTKVLTGDNeIITRAICKNVDFeitklFSGAEIeamddrqlhk 585
gi 58336553  510 fsakDENDLTIIGYLAYLDPPKEsTKEALQSLkddNVNVKIFTGDNeAVTRAIALQVGLnvdtvYDGEQIeaatseemak 589
gi 42632642  511 pgqiEEKSMVLIGLLTFLDPIKEsSTQTISSLqqkGIIVKILTGDNdILTKAIAQKLNIqttycLQGSVVdnlsddalye 590
gi 27382164  466 veteDETDLAFEGFCAFADPPKPtAAAAIAQLaarGVGLKILSGDDpVVVKRLASLVGLnpervLSGTDVaalsdaalav 545
gi 15673239  524 fsvqDESEMVLMGYLAFLDPPKEsTAKAIKALnkyGVSVKILTGDNdKVTRSVCKQVGLpvdktILGSDIdqlddnelak 603
gi 21673463  504 fthdDEKNLILLGYIAFLDPPKDsTAQALVKLreaGVKVKILTGDNaLVTRKICKDVGMavnrvVTGDELarlspdlfgk 583
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 20141214  616 eveKRAVFARLTPLQKTRILQALQknGHTVGFLGDGINDAPALRDADVGISVDsAADIAKESSDIILLEKDLMVLeeGVI 695
gi 110005412 612 vveQNNIFVKLNPLQKAKIITALKqnQHVVGFMGDGINDAPVLRQSDVAISVDnATDIAKEASDIILLEKSLLVMekGII 691
gi 42561387  635 iveDNNIFVKLNPLQKVKIIQVLKqnNHVVGYMGDGINDAPVLRQSDVAISVNnATEIAKDASDIILLEKSLLVLekGII 714
gi 52842590  571 laeGIDIYARINPMQKQRIISALKkrGHVVGYLGDGINDVPSLHHADVGISVAsAVDIAREAADIVLLEHHLKVLlnGII 650
gi 50365313  586 avvEANVFVKLSPIHKSTIIAALQaqGHVVGFMGDGINDAPVLRESDVAISFSeASNIAQDAADMILTSESLMAIenAVI 665
gi 58336553  590 iveKCDIFVHLTPELRTKIINALQknGHIVGYMGDGNKDTLAMKVADVTVTSNnAVDITKESADIILEQKDLQLLeeMII 669
gi 42632642  591 asqKTNLFTKLSPEQKARIVSVFKqkGNIVAFMGDGINDASAMKQANLGICVDsGAEITKEIADIILLEKQLTVLeqGVL 670
gi 27382164  546 qvrSTDAFGRLAPDQKSRIVRALQagGEVVGFLGDGINDAPALKVADVGLSVDgATGVAQAAADMILLASDLEVVadGVA 625
gi 15673239  604 vakEASVFAKLSPQQKARIVTTLRnsGNSVGYMGDGINDAAAMKSSDVGISVDsAVDIAKESADVILLEKDLMVLekGII 683
gi 21673463  584 aveEADVLAKLSPLQKEEVVQSLRkqGHVIGFMGDGINDAPALRAADVGISVDsAVDVAKESADIVLLEKSLMVLddGIL 663
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 20141214  696 KGRETFGNIIKYLNMTASSNFGNVFSVLVASAFIPFLPMLAIHLLIQNLMYDISQLSLPWDKMDKeflrkprkwdaknig 775
gi 110005412 692 QGRQIFGNILKYIKITIASNFGNVLSILIASAWLPFHPMMPIQILFQNLLYDVSQLAVAFDKVDVdflskpqtwttkdil 771
gi 42561387  715 QGRTIFGNILKYIKITTASNFGNALSVLIGTVWLPFSPMAPAQILLQNLIYDFSQFGVALDRVDAtfltspqrwqskdll 794
gi 52842590  651 EGRKSFRNVMKYLMMGTSSNFGNMISMAVAVLFLPFLPMLPRQILLNNLLYDISQITIPTDHVDPssihqykrldiniir 730
gi 50365313  666 EGRKSLANMLKYIKVTVASNFGNVISVIVALFLTKEEPMLALHLLLQNLLYDFVMFALVFDNVDEeflqkprpfttknii 745
gi 58336553  670 TGRKVFSNTMKYIKTFLVTNFGSVITMVVASIILPFLPLLPLQLLILDLLYSISCLVIPFDSVSRsyvkkpqqwsirkwp 749
gi 42632642  671 EGRKTYTNALKYIKFTLSSNFANSLSILLASLCLNFQPMIVLQVLFLDLIYDLICFAIPFDNVDDfylqkpckwdfasik 750
gi 27382164  626 EGRRTFANILKYVRMGASSNFGNMLSMAIASMVLPFLPMLPTQILLNNLLYDLSELGIPFDRVSAqataqpqvwsmsnla 705
gi 15673239  684 EGRKTYANMIKYIKMTASSNFGNMFSVLIASAFLPFIPMLSIHILLLNLIYDFSCTAIPWDNVDEeylvvprkwdassvs 763
gi 21673463  664 EGRRVFTNIIKYIRMGASSNFGNMFSVVGASYLLPFLPMQPIQILLNNLLYDFSQTGIPTDNVDEeqvrsprkwdignik 743
                        810       820       830       840       850       860       870
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                                                                                    
gi 20141214  776 rFMLwIGPTSSIFDITTFALMwyvfaan--------------nveaqaLFQSGWFIEGLLSQTLVVHMLRTQKIPF 837
gi 110005412 772 pFVFvNGPVSSIFDVLTFVVTgyyfgvlanp--------qhitaeqitLFQTCWFVEGLVTQTLIVQMYRTRKIPF 839
gi 42561387  795 pFTTiNGTISTFFDLITFAIAgyyfgyinsynsaiaqndsllaaqslaRFHACWFIIGLLSQTFVFQILRTEQLPV 870
gi 52842590  731 qFMFyVGPISSVFDFLTFFVMlkifs------------------aneaLFQTGWFVESLATQTLVIFIIRTAKKPW 788
gi 50365313  746 wFAViNGPISSIFDISTFLVLifgyklvpfqg------svpegstnamQFHASWFVVGLMTQTAVMQVYRTEKTPF 815
gi 58336553  750 kFMFsFGPIPAIVDFIMMALMfyvicprlvg-------pnyhhwvfisLFYSGMFIESLWTREMVIHTLRDERFPF 818
gi 42632642  751 sFMLwFGFCSFLLDFAFLIGMkfllkn---------------lsqndrLFQTSWFIFSMWSQTLTIFLLRTDKIIA 811
gi 27382164  706 rFAAiMGPLSSVFDFLTFGALimlfh------------------aspgEFRTAWFIESMATQILVIFVIRTNGRPW 763
gi 15673239  764 kFMLwIGPTSSVFDITTYLLMffvicpatfgpfsslvpgsvayigfiaLFHTGWFVESMWTQTLVIHMIRTPKIPF 839
gi 21673463  744 wFMIvIGPISSIFDYATFALMwfffnsklfidp---aatgaakahavqLFQTGWFVESLLTQALIVHIIRTRKIPF 816

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