Conserved Protein Domain Family
P-type_ATPase_K

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cd02078: P-type_ATPase_K 
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB
KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.
Statistics
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PSSM-Id: 319773
View PSSM: cd02078
Aligned: 20 rows
Threshold Bit Score: 1050.32
Threshold Setting Gi: 12229571
Created: 8-Dec-2004
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Feature 1: P-type ATPase signature motif, 7 residue positions
Conserved feature residue pattern:D K [TS] G T [LIVM] [TS]Click to see conserved feature residue pattern help
Evidence:
  • Comment:a characteristic P-type ATPase conserved sequence motif: DK[TS]GT[LIVM][TS], in which D is the reversibly phosphorylated Asp

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 2506206    10 EPTLVVQALKeAVKKLNPQAQWRNPVMFIVWIGSLLttcisiamasg---ampgnalfsaAISGWLWITVLFANFAEALA 86
gi 3121785    25 LSDLYQRAFKeAWVKLNPKIMVKNPVMFMVWVGTLItgmltlnpnlf--gvtgtsamfngLVTVILLFTVLFANFAEAVA 102
gi 53711870   11 QKEQVIESIRqSFVKLNPRMMIKNPIMFTVEVVTVImlvvtllslft---peygtfgynlCVFLILFVTLLFANFAEAIA 87
gi 12229592   13 SPELVRGAVRaSFAKLSPRDQARNPVMFVVYLGTALtayltvanlv-----tgkpwgyelAITLLLLLTVLFANFAEGMA 87
gi 124516022   8 DPNVILAASLqALAMLNPLKLVKNPVMFVVEIGSAIttliaihsll----hpdgellfttTISLWLWLTIGFANFAEALA 83
gi 12229570    9 DTDQQKQAISdSFAKLDPQYLVKNPVLFVVELGTIIglvmtiapglf---gatgsrvyyaVITVLLGFTVIFANYAEAYA 85
gi 27805410   31 TKGIYLRAIKdAFVKLNPKSAIKNPVMFVVWVATLVtlavtinpdlfgpnqqknpqlfngLLTGILFFTVWFANFAEAVA 110
gi 27805413   11 DKKILGTAVKgAFIKLNPVYMVKNPVMFVVEIGAIIslalcffpnlfg-gnnqdmilynsLVFIILLLTLLFANFSESVA 89
gi 56708741   11 SKELVVPAIKkSFTKCDPRQMIKNPVMFCVEVVTILctlylvseii-----qgqnigftlQVVIWLWFTILFANFSEGIA 85
gi 18266748   10 TKDILKEAIIeSFKKLNPKYMMKNPVMFVVEVGFFVtilltifpsifg-dkghnlrvynlIVTIILFITVLFANFAESVA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 2506206    87 EGRSKAQANSLKGVKKTAFARKLrep------kygAAADKVPAdqLRKGDIVLVeaGDIIPCDGEVIEGGASVDESAITG 160
gi 3121785   103 EGRGKAQADALRSTQTQTYAQRIla---------dGSLEMVSSthLRKGDRIVVsvGDIIPADGEVLEGVASVDESAITG 173
gi 53711870   88 EARGKAQADSLRKTREETPAKLVi----------gDKVQTVSSskLKKGDVFVCeaGDTIPADGEIIEGLASIDESAITG 157
gi 12229592   88 EARGKAQAASLRSAREDVKARRLv----------nGQEELVAGtaLERGDLVVVeaGEMIPADGEIVEGLASVDESAITG 157
gi 124516022  84 ELQGRAQAESLRSTRADTQARLIgp---------dGTTRMVPGntLKKGDQFLVesGEILPTDGEILEGVASIDESAITG 154
gi 12229570   86 ELEGEAQADSLRALQTEAEGKLLqnddvdiediseDDYEVVASteIEQDAVVFVdeGDIIPRDGTVVEGSASVDESAITG 165
gi 27805410  111 EGRGKAQADTLRSTKSEAIAKQLsp---------dGTIAEVPStnLKQGDTVYVvaGDIIPADGEVIMGVASVDESAITG 181
gi 27805413   90 EGRGKAQAASLKQTQQDMQARLIl----------nGKEKVVNAntLKKGDIVLVnmGEVIPSDGEIIEGVASVDESAITG 159
gi 56708741   86 EGRGKAQADTLKAAKSKLFALRIee---------dGSVTKVDAesLKIGDTVIFetNTLIPCDGDVIEGMATIDESAITG 156
gi 18266748   89 EGRGKAQADALKKTRKDTIAKLIgk---------dGSIKTINAneLKKGDVVLVenGDVIPNDGEVVDGVASVDESAITG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 2506206   161 ESAPVIRESGGdf-aSVTGGTRILSDWLVIECSVNPGeTFLDRMIAMVEGAQRRKTPNEIALTILLIALTIVFLLATATL 239
gi 3121785   174 ESAPVLKEPGSdvasSVTGGTRIISDELIIRVTADPGkGFIDRMIDLVEGAERSKTPNEIALTVLLAVLTLVFLIVVATL 253
gi 53711870  158 ESAPVIREAGGdk-sSVTGGTKVLSDHIKVLVTQQPGeSFLDKMIALVEGASRQKTPNEIALTILLAGFTLVFVIVCVTL 236
gi 12229592  158 ESAPVIREAGTdh-sGVTGGTKVLSDRIVIQITSGAGeSFLDRMIALVEGASRQKTPNEIALSILLSGLTLIFLLAVVTL 236
gi 124516022 155 ESAPVIRESGGdr-sGVTGGTRILAGTLRVEVTNNPGeTFLDRMISLVEGATRQKTPNEIALTILLVGLTIIFLVVVASI 233
gi 12229570  166 ESEPVIRQSGGdr-tSVVGGTEVLSDRIKVEVTSEEGeSFLDQMIGLVEDAQRQKTPNEIAMTILLSGLTLVFVVAVATM 244
gi 27805410  182 ESAPVLKESGSdvasSVTGGTRIISDELIVRVTSDPGkGFIDRMIALVEGAERSKTPNEVALTVLLAVLSLVFLFVIATL 261
gi 27805413  160 ESAPVLKESGGdf-aSVTGGTTVASDYLKIQITSNPGeSFIDKMIQLVEGASRKKTPNEIALSTLLVSLTIIFLIVIVSL 238
gi 56708741  157 ESEPVVKEAGSdn-sAVTTGTKVLSDSIKVRVTSNPGeSFLDKMIDLVEGAKRLKSPNEIALTILLSGLTLIFIFAICSL 235
gi 18266748  160 ESAPVMKEPGGdf-aSVTGGTKVVSDWLKVEITATPGeSFLDKMINLVEGASRQKTPNEIALNTILVSLTLIFLIVLVAL 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                 #######
gi 2506206   240 WPFSawgg------navsVTVLVALLVCLIPTTIGGLLSAIGVAGMSRMLGANVIATSGRAVEAAGDVDVLLLDKTGTIT 313
gi 3121785   254 PPPAnyid------spvsITLLIALLVALIPTTIGGLLSAIGIAGMDRVAQFNVVATSGRAVEACGDINTLVLDKTGTIT 327
gi 53711870  237 IPFAdytsleh-pgtaisIAAILSLFVCLIPTTIGGLLSAIGIAGMDRALRANVITKSGKAVETAGDIDTLLLDKTGTIT 315
gi 12229592  237 YPFTvyag------apasAVTLIALLVCLIPTTIGGLLPAIGIAGMDRALQANVIAKSGKAVEVAGDVDVLLLDKTGTIT 310
gi 124516022 234 PAFSsyag------vqssPTVLIALLVCLIPTTIAGLLPAIGIAGIDRAFRANVIAKSGKAVEVAGDIDILLLDKTGTIT 307
gi 12229570  245 FFFGeylasfvggfagldVAELVALLVALMPTTIGALLAAIRVAGMTRVTRRNVIAKSGRAVEAAGDLDALILDKTGTIT 324
gi 27805410  262 PAFAyyad------tpvnVPTLIALLVALIPTTIGGLLSAIGIAGMDRVAQFNVIATSGRAVEVCGDINTLVLDKTGTIT 335
gi 27805413  239 YPMAiytg------iklpVSTLVALTVCLIPTTIGGLLSAIGIAGMDRVTRFNVIALSGKAVEACGDVDTMILDKTGTIT 312
gi 56708741  236 YGMAmysn------tvlsAVVLIALFVTLIPTTIAGLLSAIGISGMDRLLKFNVVALSGRAVESSGNIDLLLLDKTGTIK 309
gi 18266748  239 YPMAtytg------vkipMSTLIALLVCLIPTTIGGLLSAIGIAGMDRVTRFNVIAMSGKAVEACGDVDTMILDKTGTIT 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 2506206   314 LGNRQASEFIPAQGVDEKTLADAAQLASLADETPEGRSIVILakqrfnlr----------------------------er 365
gi 3121785   328 LGNRLAETFLPVNGHSLKEVAAIALAASIFDTTPEGKSIVRLaekmgat------------------------------l 377
gi 53711870  316 IGNRRATKFHSAPGVGPREFVTTCLLASLSDETPEGKSIVELgresgvr-----------------------------mr 366
gi 12229592  311 IGNRMATKFHPLPGVTEAELAKAALLSSLADPTPEGKSIVALarqlgv-------------------------------d 359
gi 124516022 308 FGNRQAVQLLPAKGVSDLEMARASWLSSLSDDTPEGKSIVSLaasels-------------------------------a 356
gi 12229570  325 TGERVAQDFHPLGDADDADVVRASYQSSLYDETTEGRSIVKLaekmngkvqtdggqsaseeldepgdsvdaprdvsvtld 404
gi 27805410  336 LGNRLAEEFIPINGYSVEQLASVAWAASVFDDTPEGKSIVRLaeklgir------------------------------y 385
gi 27805413  313 YGNRMASEFIALDKGNKNYLIHYAILASIQDNTPEGKSIVTLgkdllked----------------------------ld 364
gi 56708741  310 LGNRFATDFIPLGATSLEELAYAAWLSSLVDETPEGKSIVKLaeqrfnfn----------------------------sk 361
gi 18266748  313 YGNRLAADFITVGGADKQKLIDYSVMCSLKDDTPEGKSIVELgkqlgit-----------------------------id 363
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 2506206   366 dvqslHATFVPFTAQSRMSGINId-NRMIRKGSVDAIRRHvea-ngGHFPTDVDQKVDQVARQGATPLVVVEgSRVLGVI 443
gi 3121785   378 dfdrqQAEGVEFSARTRMSGTDLpdGSEVRKGAVDAIRGFvrs-rgGKSPTGLDEAYGKVSHLGGTPLAVCRnDEIYGVI 456
gi 53711870  367 slqtaGARMIQFTAETKCSGVDLadGTQIRKGAFDAIRKItea-agNKFPKEIEEVISEISGNGGTPLVVCVdRKVTGVI 445
gi 12229592  360 apepaGAEFIEFTAQTRMSGVDFp-GTSIRKGAGSRISALaqe-rgGQLPPELAAITDEVSRQGATPLTVIEnDRLLGVV 437
gi 124516022 357 pvvpeGLKAIPFTPETRMSGVDLp-DEEIRKGAEDAVRAYt----gSSFPPGVPEIIAEIAGSGGTPLVVSRnKTVLGVI 431
gi 12229570  405 aeglsESNFVPFSAETRMSGIDLsdGTEIRKGAVDAVEEYa-----TTVPGKLRQKSNAISESGGTPLAIAVdGQVVGII 479
gi 27805410  386 dldpnLAQAVEFSAKTRMSGTNLpgGREARKGAVGAIQGFvrs-rnGQTIPELDAAYERVSQQGGTPLAVCLdNEIYGVI 464
gi 27805413  365 tndirENQFIEFTAQTRMSGVDLadGTRIRKGAYDAIIKYikn-igGEIPHDLEDKVNNISKLGGTPLVVCAeEKIYGVI 443
gi 56708741  362 dvdisQAEIIPFSAYTRMSGIDYq-GLEVRKGAISSIENYlkdkldSSLINMFRKVTEQISEQGGTPLAVAQkDKLLGVI 440
gi 18266748  364 tkkyeSIEFEEFTAQTRMSGIKLenGTAVKKGAYDAIKKRvqe-lkGVIPKDLDEAVNKVAKLGGTPLVVCVdNKIYGVI 442
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 2506206   444 ALKDIVKGGIKERFAQLRkMGIKTVMITGDNRLTAAAIAAEAGVDDFLAEATPEAKLALIRQYQAEGRLVAMTGDGTNDA 523
gi 3121785   457 YLKDIIKPGIQERFNQLRrMGVRTVMLTGDNRITASVIAKEAGVDDFIAEATPEDKIQVIQQEQAAGKLVAMTGDGTNDA 536
gi 53711870  446 ELQDIIKPGIQERFERLRkMGVKTVMVTGDNPLTAKYIAEKAGVDDFIAEAKPEDKMEYIRKEQQSGKLVAMMGDGTNDA 525
gi 12229592  438 ALSDIIKPGIRERFEQLRrMGLRTVMITGDNPLTAEAIAKEAGVDGFLAEATPEDKMEMIKQEQASGKLVAMMGDGTNDA 517
gi 124516022 432 HLKDVIKPGLKERFERLRkMGVSTVMVTGDNPLTARAIAREAGLDDFFAQAKPEDKMQLIKKEQEKGRLVAMTGDGTNDA 511
gi 12229570  480 ELQDELKPGIADRIAEIQkMGVETIMATGDNQRTARWVADQVGIDEFHAEFDPEEKIELVEDIQDDGKLVGMTGDGTNDA 559
gi 27805410  465 YLKDIVKSGIRERFDQLRrMGVRTIMLTGDNHITASVIAQEAGVDDFIAEATPEDKISVIQREQAQGKLVAMTGDGTNDA 544
gi 27805413  444 YLKDTIKPGLVERFERLRsIGIKTIMCTGDNPLTAATIAHEAGVDSFIAECKPEDKIKVIKDAQSKSKVVAMTGDGTNDA 523
gi 56708741  441 HLKDIIKPRIKERFEELRkMGVQTVMITGDNPLTAAAIAAEAGVDDFVAQASPQDKLDFIIKAQKEGKTVAMCGDGTNDA 520
gi 18266748  443 YLKDTVKPGLVERFERLReIGIKTIMCTGDNPLTAATIAKEAGVDGFIAECKPEDKIEAIKKEQDEGKLVAMTGDGTNDA 522
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 2506206   524 PALAQADVAVAMNSGTQAAKEAGNMVDLDSNPTKLIeVVHIGKQMLMTRGSLTTFSIANDVAKYFAIIPAAFAAtypQLN 603
gi 3121785   537 PALAQANVGLAMNSGTQAAKEAANMVDLDSDPTKLIdLVTIGKQLLITRGALTTFSLANDIAKYFAIIPAMFAGi--GIG 614
gi 53711870  526 PALAQANVGVAMNSGTQAAKEAGNMVDLDNDPTKLIeIVEIGKQLLMTRGTLTTFSIANDVAKYFAIVPALFMVaipELG 605
gi 12229592  518 PALAQADVGLAMNSGTQAAKEAGNMVDLDSDPTKLLeVVEIGKGLLITRGALTTFSIANDVAKYFAILPALFVTaypQLG 597
gi 124516022 512 PSLAQADVALAMNSGTQAAKEAGNMVDLDSDPTKIIeVVEIGKQLLMTRGALTTFSIANDVAKYFAILPAMFVVaypQLG 591
gi 12229570  560 PALAKADVGLAMNAGTNAAKEAGNMVDLDSNPSKIIeVVGIGKQLLMTRGSLTTFSVANDVAKYFVLLPAILAAaipGLG 639
gi 27805410  545 PALAQANVGVAMNTGTQAAKEAANMVDLDSDPTKLIdIVSIGKQLLITRGALTTFSIANDIAKYFAIIPVIFAAa--NLQ 622
gi 27805413  524 PALAQADVGIAMNSGTTAAKEAANMVDLDSDPTKILdVVEIGKQLLITRGALTTFSIANDIAKYFAIIPAMFLAiipQMQ 603
gi 56708741  521 PALAQADVGIAMATGTSAAREAGNMVDLDSDPKKIIeIVKIGKQILVTRGALTTFSITNDIAKYFVVIPALFVNafpSLG 600
gi 18266748  523 PALAQADVGLAMNSGTTAAKEAANMVDLDSDPTKVLeVVEIGKQLLITRGALTTFSIANDVAKYFAIIPAIFTIaipKMQ 602
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                                                                                    
gi 2506206   604 ALNIMCLHSPDSAILSAVIFNALIIVFLIPLALKGVSYKPLTaSAMLRRNLWIYGLGGLLVPFIGIKVIDLLLTVC 679
gi 3121785   615 ALNIMDLKSPQSAVLSALIYNALIIPALIPLALRGVKFRPLSaDQLLQRNILVYGLGGIIVPFVAIKLIDLGISLL 690
gi 53711870  606 ALNIMNLHSPESAILSAVIFNAIIIPILIPLALKGVQYKPIGaSALLRRNLLIYGLGGVIVPFVGIKLIDLVVSLF 681
gi 12229592  598 VLNVMGLHSPTSAVLSAVIFNALIIPVLIPLALRGVPYQPMSaGALLNRNLLVYGGGGILVPFIAIKLIDLLIGGL 673
gi 124516022 592 VLNVMKLATPVSAVTSAIIFNALIIPALIPLALKGIRYRPVGaSALLRRNLLIYGLGGIIVPFVGIKLIDMVLVLL 667
gi 12229570  640 AMDILNLSTPASAVTATLMYNAFIIPLLIPLALRGVDYKAQSgAQLLRKNLIVYGGGGLIAPFIFIKAIDMLFVAL 715
gi 27805410  623 SLNIMNLTSTNSAVLSALIYNALIIPALIPLALKGVQFRPLTaNQLLQRNILIYGLGGVIAPFIAIKLIDILITLV 698
gi 27805413  604 VLNIMHLSSSYSAILSALIFNAIIIPCLIPLAMKGVKYKLQRsEKMLAHNMLVYGVGGMIVPFIGIKLIDLVIAPL 679
gi 56708741  601 ALNFMGLHSSTSAILSAVIFNALIIIFLIPMALVGVKNVVASsQTLLRRNLLYYGVGGAIVPFIGIKLIDMLITAM 676
gi 18266748  603 LMNIMHLSTPYSAILSALIFNAIIIPALIPIAMKGVKYRPMKsEALLLRNMIVFGFGGIIVPFVGIKIIDMIITPM 678

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