Conserved Protein Domain Family
P-type_ATPase_Ca_prok

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cd02089: P-type_ATPase_Ca_prok 
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1
Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.
Statistics
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PSSM-Id: 319781
View PSSM: cd02089
Aligned: 23 rows
Threshold Bit Score: 976.709
Threshold Setting Gi: 125631087
Created: 26-Apr-2005
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Feature 1: P-type ATPase signature motif, 7 residue positions
Conserved feature residue pattern:D K [TS] G T [LIVM] [TS]Click to see conserved feature residue pattern help
Evidence:
  • Comment:a characteristic P-type ATPase conserved sequence motif: DK[TS]GT[LIVM][TS], in which D is the reversibly phosphorylated Asp

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 93141231   38 GLTAEVAADRLALyGPNELveqagrsplqilwdQFANIMLLMLLAVAVVSgaldlrdgqfpkDAIAILVIVVLNAVLGYL 117
gi 153937287  21 GLSSEEIEKRREKyGLNKLnskkqksllkmffeQLNDILIYILLAAAIISgilg-----evsDALIIGIVVIINTVIGVV 95
gi 81411111   23 GLTEEIASERLKQyGSNELatkqkrtlwqrifaQINDVLVYVLIIAALISafvg-----ewaDASIIALVVVLNAVIGVV 97
gi 126700119  20 GLSKERAEELLEKnGANELkeadkvptyklfleSFKDPLVIILLIAALVQiflg-----etvESIIIFAVIIINSVLGVV 94
gi 19704357   21 GLTDEEVEKRRKKyGENKFiekekdglikiffyQFKDSLVIILLVAAIISffsg-----neeSSFVIVLVLILNSILGAY 95
gi 81509919   21 GLTTSEVTKRQEKyGFNELknkkkdplwklfleTFKDPMVIVLVIAALVQlvlg-----evvESLIIFLVLIVNSIISVV 95
gi 153937578  22 GLNSKETKKQRELyGYNELvekkkdtilkvfleQFKDFLVIILIIAGIISmvtg-----nieSTIVIFAVIALNAILGTV 96
gi 58337660   23 GLSTKQAEENLAKyGKNALvegkkkttfqvfleQFKDLMVIILIIAAVISaftg-----eleSTLVIIAVLILNAVLGTV 97
gi 16802860   22 GLTKEQVKQKHAEfGTNEFeegkkesllqkighHLVEITTIVLLFAAAISaylaittgygwaKVVVILGIVVLNMVLGIY 101
gi 380033904  16 GLTTTAVTTQLTKfGKNELvaarpvplwrkiwqHMSDVSSLVLLFAVGLAtylalaqnggwtKTIVIGAILVINVCIGLY 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 93141231  118 QESRAEKALAALkgmaaplVRVRRDNrdQEIPvagLVPGDLILLeaGDQVPADARLVesanLQVKESaLTGEAeAVQKla 197
gi 153937287  96 QESKAEKALDALkqlstpkALVKRNGenIEIPsedVVPGDVIVLdaGRYVPCDLRLIetanLKIEESaLTGESvPVEKha 175
gi 81411111   98 QESKAEQALEALkkmatpkAIVKRDGelKEIPsehVVPGDIVMLdaGRYIPCDLRLIetanLKVEESaLTGESvPVDKda 177
gi 126700119  95 QTKKAESSLESLknlsapnAKVIRDNkkMTIPaknLVVGDIVFLeaGDYIPADGRLIeaqsLKVVEGmLTGESePVLKht 174
gi 19704357   96 QTIKAQKSLDSLkkmsspkCKVIREHeqLEVDsseLVPGDIVIIeaGDIVPADGRIIenfsLLVNENsLTGESnSIEKtd 175
gi 81509919   96 QTRKAESSLDALremsapvAKVIRDGskQSIHareLVPGDVVILdaGDFVPADGRLFesgsLKIDEGmLTGESeAVEKyi 175
gi 153937578  97 QHVKAENSLNSLkklssphAKVIRDGkkIELLskeIVPGDILILeaGDYVPADGRIIenysIQVNESsLTGESeSVLKta 176
gi 58337660   98 QHIKAEKSLESLkslsspsAKVLRNGekIEIDskdVVPGDIMLLeaGDMVTADGRILdnfsLQVNESsLTGEStNIDKad 177
gi 16802860  102 QENSAEKALAALqsmnahlTTVIRDGvrMQVDateLVPGDIIEIvaGDMIPADARIIssssLQVEESaLTGESvPVEKda 181
gi 380033904  96 QEASAEKSLAALksmslptANVRRDGkvQTIAapeIVPGDLVLLkaGDQVPADAVVLeatnLAVDEAvLTGESeAVEKsi 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 93141231  198 dqqlptd----vvigdrtnCLFQGTEVLQGRGQALVYATGMNTELGRIATLLQSVESEKTPLQQRLDKLGNVLVSGALIL 273
gi 153937287 176 kekledp---ktplgdqknMAFMSTLATYGRGIGIAVGTGMNTEIGKIAKMLEGEDKELTPLQKKLAELGKILGFAALGI 252
gi 81411111  178 iyhpsmqsdeqvplgdqknMAFMSTLVTYGRGVGVAVETGMNSQIGKIATLLHEADDDMTPLQKSLAQVGKYLGFVAVAI 257
gi 126700119 175 ekised-----vslgdqknMVFSGAVVVYGRGSFVVTGTGMDTEMGKIAGLLESAENKLTPLQQKIEDFSKKLGVGIVIL 249
gi 19704357  176 eilqyed----lalgdqvnMVFSGSLVNYGRAKILITETGMSTELGKIATLLDQTEENVTPLQKSLDIFGKRLTLAIVIL 251
gi 81509919  176 dtipde-----vglgdrvnMVFSGSLVVYGRGMFVVTGTASETEIGKIAGLLETAEAKQTPLQRKLESFSKKLGLGILAL 250
gi 153937578 177 ntisend----ialgdqknMVFSGSFVTYGRATVVVTNIGMNTEIGKIASLIENTQEKKTPLQVSLDDFGKKLAMIILVI 252
gi 58337660  178 vdfdhe-----iplgdrlnMVYSSSLVTYGRANVLVTNTGMDTEIGKIASLMNETKERRTPLQVSLDKFSSKLATAILII 252
gi 16802860  182 navvsek----apigdrlnMLYSGCLVTNGRATAVVVEIGMETEMGKIAGLLNSTSKLMTPLQLRLKELAKRLSIVALLA 257
gi 380033904 176 yqdtg--------elddncQVYAGTAVTAGTALIQVLTTGMATELGQIAGLLNKTKQRATPLQGRLNRLSSWLTTFAVLG 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 93141231  274 VAIVVGlg-------vLNGQSWEDLLS-------VGLSMAVAIVPEGLPAVITVALAIGTQRMVQRESLIRRLPAVETLG 339
gi 153937287 253 CALMFIia-------lFQKRDILEMFL-------TAISLAVAAIPEGLPTIVTIVLAMGVQKMIKENAIIRKLPAVETLG 318
gi 81411111  258 CIVMFLig-------fLQRRDTLEMFM-------TAISLAVAAIPEGLPAIVSIVLAIGVQRMIKQNVIIRKLPAVEALG 323
gi 126700119 250 ALLIFIiqvarnyfmaGNGEMTQIILDsf----mFSVAVAVAAIPEALSSIVTIVLAVGTNSMAKKQAIIRKLPAVETLG 325
gi 19704357  252 CIFIFGiy-------vYHGNTVLDSLL-------LAVALAVAAIPESLNPIITIVLSLETEKLAKENAIVKELKSIEALG 317
gi 81509919  251 CVLIFAvea----grvLLGDNSADMATailnafmFAVAVAVAAIPEALSSIVTIVLAVGTNKMAKQHAIIRKLPAVETLG 326
gi 153937578 253 SALIFLld-------iHRGSSVLNSLM-------FAVALAVAAIPEALSSIVTIVLAIGTQKMASENAIIKKLKAVEGLG 318
gi 58337660  253 CALVLGlq-------iWRGQPIMDALL-------FAVALAVAAIPEALSSIVTIVQAMGTQKMAKENAIIKNLAAVESLG 318
gi 16802860  258 GILIFIid------vyVYGETIIETLM-------IAISLAVAAVPETLPVIVTLTLAYGVQNMVRKNTIIRRIPAVETIG 324
gi 380033904 248 GITIFAls------vwVQNQGLADSLM-------IGVSLAVAAVPETLPIIVTISLSHGVRRMADRNAIMRRVSAVETIG 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #######                                                                  
gi 93141231  340 SVTTICSDKTGTLTQNKMVVQQIHTldhdftvtgegyvpaghfliggeiivpndyrdlmlllaagavcndaalvasgehw 419
gi 153937287 319 AVNIICSDKTGTLTQNKMTVIKFYAnkemqdidklniedsihkm--------------------llenlvlcndatfskd 378
gi 81411111  324 SVTIICSDKTGTLTQNKMTVTHFYSdntydqlenlnvnndvqrl--------------------llenmvlcndasynne 383
gi 126700119 326 STSVICTDKTGTLTQNKMTVVDYYMygtnndeldkekvnysyhak-----------------lltmvstlcndshitsdg 388
gi 19704357  318 SISVICSDKTGTLTQNKMTVKKIFIngklddeyslninkkid------------------------kllldsfilctdat 373
gi 81509919  327 STSVICTDKTGTLTQNKMTVVDYYLpdgtkenfpespenwseger-----------------rlihiavlcndsninseg 389
gi 153937578 319 CVSVICSDKTGTLTQNKMKTEKIYTndkifesnefdlknsvqnl--------------------likssilcndstvqqd 378
gi 58337660  319 SVSVICSDKTGTLTQNKMTVEEIYIggevlkpnqlnldnqlhry--------------------llydavlnndsslkdg 378
gi 16802860  325 NTSVICSDKTGTLTQNKMIIQQIWAadhtpikataefdtaeqkvl-----------------emlslssnatidvtdgee 387
gi 380033904 315 SVDVIASDKTGTLTQNRMTITKYWTpttgimtteqplpsagqtlm-----------------rylglatnaeinhvdgee 377
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 93141231  420 siVGDPTEGSLLTVAAKAGidpegl----------qrvlpRQDEIPFTSERKRMSVVVAdlgettltiregqpYVLFVKG 489
gi 153937287 379 ssTGDPTEIALLEAGAKYNiiknni----------enehkRIDEIPFDSDRKLMTTVNNfd----------dkNYVMTKG 438
gi 81411111  384 sqTGDPTEIALLVAGSTFNmqkdyl----------ekiheRINELPFDSDRKMMSTVHTyd----------esYYSMTKG 443
gi 126700119 389 keVGDPTEVALINYSSKNDldydkl----------rskyiRINEIPFDSDRKLMSTVNSiy----------gdYIMFTKG 448
gi 19704357  374 dtIGDPTETALIHLTQKYDmsfrde----------rkdskRISEIPFDSVRKLMTVLYEdkk---------gkYIIFTKG 434
gi 81509919  390 keLGDPTEVALIAFSNKNNqdynei----------rekfiREGEIPFDSDRKLMSTLHTfn----------enKAMLTKG 449
gi 153937578 379 kkIGDPTEIAFVELGKNYSldeldl----------rktypRLSEIPFDSNRKLMSTSHKid----------gqYLMITKG 438
gi 58337660  379 ksIGDPTESALLEMYRQVPgidlgnnqlglsesdlrglltRQQEVPFDSDRKLMSTKHLih----------tvPTIFVKG 448
gi 16802860  388 tiIGDPTESAIIRLLEEKGttkkal----------eakypRVFELPFDSDRKLMTTIHQve----------dgFLSITKG 447
gi 380033904 378 qaIGDATELAVIRWLAQHDldrpsl----------eaqtpRIAEDPFDSTKKMMTTVHElah---------grRLVIVKG 438
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 93141231  490 SAELILercqhcfgnaq-lesltaatrqQILAAGEAMASAGMRVLGFAyrpsaiad---vdedaetDLTWLGLMGQIDAP 565
gi 153937287 439 AIDNLLkistnayinge-vvpltdeikqNIMNASNEMSKNALRVLGAAyktlednn--ynkeslesNLTFIGLVGMIDPP 515
gi 81411111  444 AIDKLLprcthilkngk-ievlteadknQILEAARAMSREALRVLSFAfkqynssn--vdidhleeNLIFIGLVGMIDPP 520
gi 126700119 449 APDIVFsrckyalkngs-kvditdeiieEYKHKNEEFSNRALRVLAFAikdvpeedf-ipsiddehDMTLVGIMAMIDPP 526
gi 19704357  435 AFDSLItkfkyfidengdiqnineefikKIEKVNNDLAEEGLRVLTFAykymdepk--dlttqdedSYIFHALVGMIDPP 512
gi 81509919  450 GPDVMFarcsyvfldge-ekpmteeilaKLKETNEEFSNQALRVLAYGykrmpadtt-elkledeqDIVLVGLTAMIDPP 527
gi 153937578 439 AVDVLLkrikyirtseg-ikeftekdkeKIESINYEFSQKGLRVLAFAykeikedv--elsmddenNYVFLGLISMIDPP 515
gi 58337660  449 AIDVLLdrcdnirigdn-vrpmttedkkKILAQNEHFSENGLRVLTFAykekded----lspetenGFTFIGLVAEMDPP 523
gi 16802860  448 AFDRIPvnfse-------------aflaEAERVHDSFAEDALRVLVVAykkypemptdlssealetDLTFAGMVGMIDPP 514
gi 380033904 439 AWDRLPlkpdq-------------aslaAGQVAHDEFGQAALRVLAVGyriipadvqttdwddltaDLQLAGLIGLIDPP 505
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 93141231  566 RpeVREAVQRCrqAGIRTLMITGDHpLTAQAIARDLGItevgHPVLTGQQLsamngaeLDAAVRSVEVYARVAPEHKLRI 645
gi 153937287 516 ResVKDSIFECknSGIKTIMITGDHkITAFAIAKELGIaedeSQAIFGYELddmsdteLSSKIENLRVFARVSPEHKVKI 595
gi 81411111  521 RteVKDSITECkkAGIRTVMITGDHkDTAFAIAKELGIaediCEIMIGTELdnisdteLASKIDHLHVFARVSPEHKVKI 600
gi 126700119 527 ReeVMDAVKEAksAGIKTVMITGDHkTTAAAIAKEIGImeegDLALTGKELdalseeqLYEKLENISVYARVSPENKIRI 606
gi 19704357  513 ReeSKVAVQECirGGIKPVMITGDHkITARTIAKNIGIfkdgDMAIEGVELekmsdeeLENSVEKISVYARVSPEHKIRI 592
gi 81509919  528 ReaVYASIEESkkAGIRTVMITGDHkTTAQAIGRDIGLmdadDIALTGQELdampeeeLDKKLEHIAVYARVSPENKIRI 607
gi 153937578 516 ReeSYAAVKQCiqAGIKPVMITGDHkITASSIASQIGIlrnnDEAIEGVELdkisdeeLKDRVENISVYARVSPEHKIRI 595
gi 58337660  524 RkeSVEAVARAkkAGIRTVMITGDHkVTAVAIAKKIGIftegDIAVTGLELdkmsdeeLEQKIEKIAVYARVSPENKIRI 603
gi 16802860  515 RpeSKAAVLAAkkAGIKTVMITGDHiVTASAIAKEIGIltdgDKAITGAELaemseadLEKNIRDYAVYARVSPEDKIRI 594
gi 380033904 506 RpeVIPAIRAAkqAGIFPVMITGDHlVTAKAIAEEIGIltpgLQAISGDELrqlsdeeLTAQIDQIAVYARVSPSDKIRI 585
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 93141231  646 VESLQRQGEFVAMTGDGVNDAPALKQANIGVAMGitGTDVSKEASDMVLLDDNFATIvaAVEEGRIVYGNIRKFIKYILG 725
gi 153937287 596 VKALKSKGNIVSMTGDGVNDAPSLKAADIGVAMGitGTDVAKGASDMVLTDDNFSTIvsAIKEGRNIYNNIKKSIIFLLS 675
gi 81411111  601 VKALRAKGNIVSMTGDGVNDAPSLKQADVGVAMGitGTDVAKGAADVVLTDDNFSSIvkAVEEGRNIYRNIKKSILFLLS 680
gi 126700119 607 VKAWQHKNNITAMTGDGVNDAPALKQADIGIGMGs-GTDVAKDASAMVLVDDNFASIvnAVEVGRTVYSNIIKSITYLFA 685
gi 19704357  593 VNAWQKLGKICAMTGDGVNDAPALKKANIGIAMGitGTEVSKNAASMILADDNFSTIvkAIITGRNVYRNIKNAIGFLLS 672
gi 81509919  608 VKAWQKKGKITAMTGDGVNDAPALKQADIGVAMGs-GTDVAKDSAAMILTDDNFVSIvdAVGVGRTVFDNIKKSIAYLFA 686
gi 153937578 596 VKAWQEKGKIVAMTGDGVNDAPALKQADIGIAMGitGTEVSKDAASMILTDGNFATIvkSISNGRSIYSNIKNAIRFLLS 675
gi 58337660  604 VNAWQNKDKIVSMTGDGVNDAPALKKADIGVAMGitGTEVSKDAASMILADDNFATIikAVANGRTVFENIKNAIMYLLS 683
gi 16802860  595 VKAWQKNGEIVTMTGDGVNDAPALKAADVGAAMGitGTDVSKNAADMVITDDNFATIvdAVKEGRTAYENIRKTIYFLLS 674
gi 380033904 586 VQAWQSLGKTVAMTGDGVNDAPALKAADVGIAMGitGTEVSKEAADMVLTDDNFATImaAVKEGRTVYQNIIKAVEFLVG 665
                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....*..
Feature 1                                                                 
gi 93141231  726 SNIGELLTIASAPLLglgavPLTPLQILWMNLVTDGIPALALAVEPgdPTIMQRRPH 782
gi 153937287 676 CNLGEILALFIGILLgw-psPLRPIHLLWVNLITDSLPALSLGIDPgdPDIMDEKPR 731
gi 81411111  681 CNFGEIITLFLAILLgw-atPLRPIHILWVNLITDTLPALSLGVDPedPDVMKEKPR 736
gi 126700119 686 GNLGAIVSIVFAVFAgw-snPFTALQLLFINLVNDSLPAIALGFEKseKNIMNKPPR 741
gi 19704357  673 GNTAAILAVLYSSLAnl-pvIFSPVQLLFINLLTDSLPSIAVGVEPknEDILDEKPR 728
gi 81509919  687 GNLGAIIAILFALVLdw-inPFTALQLLFINLVNDSLPAIALGMEKaePDVMKRKPR 742
gi 153937578 676 GNTAGILSVLYASLFal-pvPFAPVHLLFINLLTDSLPAIAIGVEQtkNDLINEKPR 731
gi 58337660  684 GNLSAIITVLFASIGgf-svPFIAVQLLFINLVTDSLPALAIGMEPgaPDVLDRKPR 739
gi 16802860  675 TNFSQIFIMLIAIILgw-gaPVVAVQLLLINVVSDGIPGFFLSREKadDSIMERKPI 730
gi 380033904 666 VNFAQIFLMVGAVLFgw-gaPLLAEQLLIINVLADGIPGFFISQEPgePQAMQQPPV 721

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