Conserved Protein Domain Family
PurM-like3

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cd02192: PurM-like3 
AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two conserved domains and seem to dimerize. The N-terminal domain forms the dimer interface and is a putative ATP binding domain.
Statistics
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PSSM-Id: 100028
View PSSM: cd02192
Aligned: 26 rows
Threshold Bit Score: 304.904
Threshold Setting Gi: 118468587
Created: 6-Mar-2002
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ATPdimerization
Feature 1:putative ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 84489827   10 IRTFKGVTRKRSIADVREKLkdvynvs-------------gnvylafGDDAAavdigNNQLMLLATDGIWGALMDVNPWW 76
gi 110819850 164 LAGAPHVHMTWPIDRVERLVqstksclahtlapfgthgdalggsgfrGDDGAp---vPGSDLIAACDAILPAMVQRDPEW 240
gi 158318397 178 VAGRPHVLMRWPINRLAAVAasikaplatll-----agmrpggpgfvGDDGAp---vPGTDVVAACDAIVPSMVERDPYW 249
gi 116250429  13 VSASSGIAAKQDIGTIAARLglqgq------------------qiavGDDCAal-pdGDGYLLFAIEGFMNEFVAADPWF 73
gi 121605002  20 LVAGRGFAHKRDIGDAMRVLsralpdath----------qrdqavalGDDCAai-rdGDGYLLFAIEGFVDDFVQRMPWF 88
gi 156451634  14 IQDARGLAHKRDIDAVVARLglssrh----------------aavpvGDDCAai-pdGDGHLLFAIEGFLDSFVAADPYF 76
gi 162149508  12 LRDGGALSAKRDIAATVAALggaalgyd------------ggdairlGDDCAai-pdGDGYLLLAGEGFQDGFVGAMPWF 78
gi 162457284   9 LRGAIGVLAKRDVQIPARHLsgapgaagaalag--daagsverpaalGDDCAai-pdGDGYLLLAAEGIWPAFLEGDPRF 85
gi 38016631   12 LHAFSGIAHKRDIQQVARELrdawp-----------------npspnGDDCAli-pdGSGYKLLAIEGFINRFVAEDPWF 73
gi 36784622   10 LKHTPAMQSKQAIAHNVSIDttchmdsl------------dslyaypGDDTAav-slNGQYVLHACEGMLPSFVTNHPYF 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #                                          ###                       
gi 84489827   77 AGYCSVLVNVNDIAAMGGRPMGMTNVLSSsnpeiTAQIMDGIKEGVKKFGVPMVGGHTHPdt-pyDALDVAISGIVDkda 155
gi 110819850 241 AGWCAALVNLNDLSAMGAVPVGMLDSVGApntsiLAKVIRGLSRAAEAWDVPVLGGHTQLgv--pAALSVTALGRTAdpv 318
gi 158318397 250 AGWCGVLVNLNDLAAMGARPVGMLDAVAGptasrVARVIGGLRAAAERYGVPILGGHTQLgv--aAALSVTALGRSErpi 327
gi 116250429  74 AGWCGVMVNISDVVAMGGRPIAVVDAVWAngeagATPVLEGMRAASSAFGVPIVGGHTNIrs-erGQLSVAILGRAKtll 152
gi 121605002  89 AGYCGVMVNVSDIYAMGGRPIAVVDAIWSqgagtSEQVMVGMAEASRRYGVPIVGGHTNHrs-dhGQLAVAILGRARkll 167
gi 156451634  77 AGYCGIMVNLSDVAAMGGRPIAVVDALWSrdtaaADPILAGLSDAAALYGVPVVGGHTNTra-acGNLAVAVLGRAGprl 155
gi 162149508  79 AGYCGVMVNVSDIAAMGGRPVAVVDALWSegaeaAAPILRGLRDGARTYGVPVVGGHTSMgs-lhNSLSVAILGRARrll 157
gi 162457284  86 AGYSAVMVNVSDVYAMGGRPIAVVDVVWGtsagaLEPVWEGMVAASRAYGVPIVGGHTSArs-pyNALAVAIAGRARrli 164
gi 38016631   74 AGWCGVMVNLSDIAAMGGRPLAVVNALWDeaqphAAQILQGMAAASRAYQVPIVGGHTNLrs-drSQLAVAVLGETAspl 152
gi 36784622   77 AGWSAVMANISDIAAMGGRALSVVNSFWHtssehAQLLMQGMQDACRAYGVLLVGGHTNIgvvyqPTLSVAIQGIARkll 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 84489827  156 vipscgaVNDDNVIVAIDLDGdv-ypGTEINWDTTSDKSPSYvqnqiNVMETIGKkhl----vhAAKDISNPGIVGTLGM 230
gi 110819850 319 p--agggRIGDELTLTADLDGqwrpgYTGQQWDSTSHRSRGAl----RDMASFVArtr----paAAKDISMAGIAGTTGM 388
gi 158318397 328 p--agggLPGHAVTLTADLGGdwrpgYSGRQWDSTSNRRTAEl----RALLDLPRrhr----pcAAKDVSMVGIVGTLGM 397
gi 116250429 153 t--sfdaKPGDVLVAAIDHRGry--rEPFNNWEAATDAAPARlrgdlELLPEIAEagl----alSAKDISQGGIVGTAIM 224
gi 121605002 168 t--sfdaLPGHRLLMAIDLRGay--qEPNPYWDASTSAPAERlradlELLPILAEdgl----cnAAKDISMAGAVGTALM 239
gi 156451634 156 lt-sfdaAPGDDLVAAIDLRGrf--rDPHPYWDASTGAPGERlrgdlAVLPGLAEdgl----asAAKDISMAGVVGTALM 228
gi 162149508 158 t--sfdaRPGEAVIAAIDLRGrw--hDPHPFWDASSALCGTAsaarlRADLDLLPaiaeeglsrAAKDISMAGLLGTALM 233
gi 162457284 165 t--sfaaRPGDVLVAAIDLRGem--hAEHPFWNASTGADPARlrgdlEVLPALAEagl----cdAGKDISMGGVAGTLLM 236
gi 38016631  153 s--ssaaQAGQTLMVAINLQGrw--hPPGNNWDAATRADPAElrralALLPELAAegs----lcAAKDISQAGLAGTLTM 224
gi 36784622  157 s--vlhvKPQQKILIALNLKGqf--hPNTPYWKCFERVSDRIlqsqiALLPQLAEanl----vhAARDISNAGILGSLLM 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1                                                                        
gi 84489827  231 LLEASDMGAHIDLESIPRAndidWISWFKMYPGSAFVLTAPeettdetlsllnKAHIDANCVGK 294
gi 110819850 389 LAEASGLGAVLDVASVPRPpvatAGDWMTCFPGFAMITADRrgsa-----vapAGPATSAVCGE 447
gi 158318397 398 LAEASGCAAELDVAAVPRPagatVGDWLTCFPGYAMLTADVddrp-----vpaPSPATSQRCGR 456
gi 116250429 225 LAECSHVGIDIDVTAIPLPagvsLDRWLVTFPSFGYLLSVApkdvadvvtrftARGISAAVIGA 288
gi 121605002 240 LLECSEVGAMIDIEAIPRPlgvpLLRWLQSFPSFGFVLSVRpevadevvarfhARGIACADVGE 303
gi 156451634 229 LLECSKVGGVIDLDAIPKPehvpLARWLSAFPSFGYLLSIRpdrtpavrarfaERGLASARIGR 292
gi 162149508 234 LAECSGIGMTVTLDDVPRPegapLERWLRAFPSYGFLLTARpgdadailarfrGRGIAAAVIGC 297
gi 162457284 237 LLETSGAGAVLDLEAVPRPrdvpLARWLLAFPSYGFLLSVRpgvagevlsafaRRGIASAAVGA 300
gi 38016631  225 MLESCGLGAEVTLEQIPIPaeidLEQWLCAFPSFGFLLAVDearchevaqrfaACGIACAVAGH 288
gi 36784622  229 LLEATASGAHINLDTIPKPenvdWFKWLQIFPSFGFLLTADtneceeiiklfhRQGIACAVIGE 292

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