1CLI,2Z01,2BTU,2V9Y


Conserved Protein Domain Family
PurM

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cd02196: PurM 
Click on image for an interactive view with Cn3D
PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. The N-terminal domain of PurM is related to the ATP-binding domains of hydrogen expression/formation protein HypE, the AIR synthases, selenophosphate synthetase (SelD), and FGAM synthase and is thought to bind ATP.
Statistics
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PSSM-Id: 100032
View PSSM: cd02196
Aligned: 123 rows
Threshold Bit Score: 260.485
Threshold Setting Gi: 34539946
Created: 31-Jul-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative ATPdimerization
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:putative ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #                         
1CLI_A        40 GGLGGFGALCAlpqkyrePVLVSGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATgkldvDTA 119
gi 118194860  36 HGFGHYAGMVDgg---ggMLIATHTDGVGTKVMIAGRMKKYDTVGIDCIAMNVNDVVCVGARPVSFVDYIAAskndgDIL 112
gi 84489101   36 KNKGHFAALVDfg----sRAIAMSTDGVGSKILIANLMNKFDTVGIDCIAMVVNDILCVGAEPIAMVDYLAVehpdpEVA 111
gi 6685782    36 TGAGHFAALVRmg----dVAIAMSTDGVGSKILVAEMMNRYDTVGIDCIAMVVNDILCVGARPAALVDYLAVerpdpEVA 111
gi 52550099   45 LGIGYFANVIDlg---qgSGLAVATDGVGTKILIAQMMDKYDSVGIDCIAMNVNDILCVGAEPISLVDYIALcepdpELL 121
gi 52549253   43 IPIGHFSGVIDlg---dgRAMAVKTDGVGTKVFIAQEMDKYDTIGIDCVAMNVNDILCVGAEPISLVDYIAVqepdpDLL 119
gi 38605377   41 TGIGHYAGLLDfg----eYALAMTTDGVGSKVLIANEMKRWNTVGIDCIAMNVNDLLAIGAEPVAFVDYLALekheeGFA 116
gi 38605114   38 ILTSHYAGVIDcg----dFGITITTDGVGSKILVAEKMRKFDTIGIDCVAMNVNDLLAIGSEPLAMVDYIAIekpdeWIM 113
gi 110621734  36 GGEGHYAGLIDmg----yFALAITTDGVGTKLLIADAIEKWDTIGIDCVAMNVNDLYVMGIEPLAFVDYISLekpnpELV 111
gi 88604283   39 SEIGHFAGFISfg----kYVLAMAVDGVGTKMLVADALQDWSTVGIDCIAMNVNDLYVMNLEPVAFVDYIATselsqEQM 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                           ###                                                          
1CLI_A       120 SAVISGIAEGCLQSGCSLVGGETAEMPGmyh----geDYDVAGFCVGVVEKseiidgskvsdGDVLIALGSSGphsnGYS 195
gi 118194860 113 SDIARGLARGAVKASVPIVGGETAIMPGlfsg--rgfAFDLAGTVVGLVPRkkmilgssikqGDAIIGAHSTGlhsnGYS 190
gi 84489101  112 SQIGKGLKVGCQQAKIAMIGGETASLPKii------kDFDLAGTGIGTVDKediitgtqikdGDIIIGIESSGvhsnGLS 185
gi 6685782   112 GEIGKGLAMGAEMARVAIIGGETASLPGii------rNLDLAATGIGFVDVdriitgedvspGDTVIGLESSGihsnGLS 185
gi 52550099  122 EEIGKGLLKGAEIANITISGGEIAIVKDmvkgvrknrEFDLVGTAVGTVSLdkiivganiqeKDVIIGLSSSGihsnGLS 201
gi 52549253  120 EAIVKGVVEGCRQARVTLSGGEIAIMPEmirgprenrGFDLVGMGVGIVSKdkiitgaaieeGDAILGLASSGihsnGMT 199
gi 38605377  117 AQIGEGLLKGAEISRMSIVGGETATLPDii------kGFDLAGTCLGVVKKedileggkvrvGDVLVGIPSTGvhsnGYT 190
gi 38605114  114 AEIAKGLEEGCRIANITLLGGETATLPEii------rGFDLAGTAIGWVKKdaiitgekieeGDVIFAIPSSGihsnGLT 187
gi 110621734 112 RQTMIGLNEGARQANVSIVGGETAALPDii------kGFDLAGTAVGVVPKdriitgkdvkpGDVIVGLPSSGihsnGYS 185
gi 88604283  115 RQIGKGLNEGARQANLSILGGETATLKGlv------tGLDLAGACLGIQEKekvisgsaitpGDCMVGIPSSGihsnGLT 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1CLI_A       196 LVRKILEVSgcdpqttel---dgkpladhLLAPTRIYVKSVLELie-kvDVHAIAHLTGGGFwENIPRVLpdnTQAVIDe 271
gi 118194860 191 LARKALGRLplntkmn------rgtlgdaLLAPTEIYSAPVLEAas-kcKVHGLAHITGGSF-TKLPRLKd--AGFEIDa 260
gi 84489101  186 LARKALLEIanfnvddklptdnsttvgeaLLEPTIIYVDAIMDLlnsdiEVHGLGHITGGGF-SNLKRLNh-dMTYIINn 263
gi 6685782   186 LARRVFFDElelspedemp-gssssvgdeLLRPTRIYVEPIMELiesdvDVHGLAHITGGGF-GNLKRLRk-dVGYRLDs 262
gi 52550099  202 LARHIFLKTgaidehfdv---lektigaeLLEPTHIYVPEIMEMinsnlDIKALMHITGDGF-LNLTRVKs-dVGFVIEy 276
gi 52549253  200 LARKVLLNKfgadeyide---lgrtvgeeLLEPTNIYAREIREMldsglDLRSLAHITGDGF-LNLRRVSm-aYGFKIDn 274
gi 38605377  191 LVRKIIEKSgysyhdpcpy-dssktigdeLLEPTRIYIEVLDVLka--cEVHGLAHITGSGL-LKLRRVTk--LGFEFSd 264
gi 38605114  188 LARKVVEAAglsyhdkf----gdktigeeLLTPTRIYMEILDVLre--cEVHGLAHITGSGL-LKLKRLKn--MKYVIDk 258
gi 110621734 186 LVRKVVESAglkytdpcpy-nkkvslgeeLLTPTRIYAEVVGLAkr--fNIHGMAHITGGGL-MNLKRITs--YGFDFTd 259
gi 88604283  189 LARRMVEQHgsysdrlp----sgatlgdeLLRPTRIYADAIQVCae--tAVHGMCHITGGGL-LNLNRLGe--FGYVFDa 259
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1                                                                       
1CLI_A       272 sswqwpEVFNWLQTAgnveHHEMYRTFNCGVGMIIALpapeVDKALALLnangenAWKIGIIK 334
gi 118194860 261 lp-eppEVMRLIKDRgv-sEKEMYRTFNMGVGFCVVApeseQGRIISIFkrhrirSGRIGRII 321
gi 84489101  264 lp-etlPIFKAIQATgi-eDKEMYHVFNMGIGFAVILdgkyQDEALEILnky-hkSYVIGEIK 323
gi 6685782   263 lp-epqQIFRVIHEAgv-dIREMYRVFNMGVGFCAVVapddVDEALSILgd---rAHPIGEVT 320
gi 52550099  277 lp-eapPIFTLLQKRgnvtDEEMFRVYNMGIGFCVILpeqeAEAAIEIAgrhkvdAFRLGYVV 338
gi 52549253  275 lp-ktpPIFELIRKHgpvsAAEMYQVYNMGIGFCIVLpadeVDSAVQIAekhgkdCYKIGSTF 336
gi 38605377  265 pi-epqEIFKFLQKEgeveDLEMYRTFNMGMGFLMILpekdAAKAAELTg-----GKIVGKIV 321
gi 38605114  259 pl-kpqEIFRFIQKLgeveEAEMYRTFNMGMGFMVILpedeADKLKKLCe-----GRVVGYVE 315
gi 110621734 260 pl-pvpEVFKFIQKTgnieDEEMYRTFNMGMGYVIICdkqdAGAIVKMTd-----GTIVGKIV 316
gi 88604283  260 pl-ppqEIFEWIAKAgqisEPEMYRTFNMGMGYVFILpkegVKTVQKYFp----dAQIVGHIT 317

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