Conserved Protein Domain Family
HypE

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cd02197: HypE 
Click on image for an interactive view with Cn3D
HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the ATP-binding domains of the AIR synthases, selenophosphate synthetase (SelD), and FGAM synthase and is thought to bind ATP.
Statistics
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PSSM-Id: 100033
View PSSM: cd02197
Aligned: 92 rows
Threshold Bit Score: 350.596
Threshold Setting Gi: 148259348
Created: 31-Jul-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP bindingdimerization
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                            #                        #  
2Z1T_A        14 SGGRASHRLISDLFLRHFdnpilgtln----------daarldltGPLAMSTDSYTVDPIFFPGGDIGTLAVHGTVNDVS 83
2Z1U_A        14 SGGRASHRLISDLFLRHFdnpilgtln----------daarldltGPLAMSTDSYTVDPIFFPGGDIGTLAVHGTVNDVS 83
gi 119720516  17 QGGVETLRLLEELFFRRVkehlkrveggvgidfpddgaliplpggGFLVVTADSYTVNPPFFPGGNIGSLAVHGSINDVV 96
gi 145591522  11 AGSVETSQILESLIFSKIeerlkkvegglgidfpddaaaipmgdgRFLVVTVDSYTVNPPFFPGGDIGVLAASGSINDVL 90
gi 124027900  22 SGGRETGEIVEKLIRPMVpeelwrveggwgldvlddsaliplpdgRYLAFTVDSYTVKPLFFPGGDLGKLAASGVINDLL 101
gi 170174817  11 SGGKETSLILKSLILSALseeelslrggvglkelddgaaiplpdgTYLVVSIDAYTVNPPFFPGGDLGKLAACGTINDIL 90
gi 126464925  13 SGGFETLEIIEKLIVHRVpenlrkvldgvgl-dvlddgssmrignTHIVISTDNFTVKPLFFPGGDIGHLAVSGVLNDLV 91
gi 126460174  10 AGGVETSEILQRLIFSKVppglkkveggvgi-dfpddaaaipvgdGYIVVTTDSYTVSPPYFSGGNIGTLAASGTINDVV 88
gi 156937284   9 GGGRETEEFIKNFILPLFkirslgsvgldd---ledgaavpigdnKYLVVSVDSYTVSPPFFPGGDIGKLAATGSLNDVA 85
gi 163765534  15 SGGRAMRQLIEDVFLSLAspvdgiglsal------ddgaairvgdRWLVITTDSHVVHPIFFPGGDIGRISVSGTVNDLA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2Z1T_A        84 MLGAR-PRYLSCGFILEEGLDMDILERVVASMGKAAREAGVFIVTGDTKVVPRGacdkMFINTTGIGEILvdpapsgdra 162
2Z1U_A        84 MLGAR-PRYLSCGFILEEGLDMDILERVVASMGKAAREAGVFIVTGDTKVVPRGacdkMFINTTGIGEILvdpapsgdra 162
gi 119720516  97 MMGGR-PVAMLDTIVVEEGFPMGDLEAIVNSMLEALEKEGVPLIGGDFKVMPKGqldrITVTTVGLGVARspivd---kp 172
gi 145591522  91 MLGGK-PIALMDAIIVEEGFPLEDLRRIVDSMLRVLREEGVALIGGDFKVMPKGqidkIAIATVGIGIADrlivd---rp 166
gi 124027900 102 MAGAK-PLAAVDAVVVEEGFPVEDLARILESLASTLAANKVALIGGDFKVVPKGdldgVIITMAGVGVAEkpivd--tri 178
gi 170174817  91 MMGGE-PKAILDSIVVEEGSPISDVRRIVNSFIGVLREEGVKLIGGDFKVMPRGqldrYVVTTAGIGIAKrpivd--ssi 167
gi 126464925  92 MMGAR-PIAFMDGIIVEEGFPRDDLDRILESMIKLLKENNVALIGGDFKVMPKKsldgLIISGTGIGLAEkpiid---ki 167
gi 126460174  89 MMGAR-PIAALDAIIVEEGFPVKTLEDIVESMISIFTKEGVALIGGDFKTMPKGqidgVVITTVGIGISKgpviv--dkp 165
gi 156937284  86 VMGAE-PKALMDAIIVEEGFKLSDLKTILKSMSEVTNSLNVALLGGDTKVMPKGsvdkIVISTVGIGIAEgplltl-drg 163
gi 163765534  89 MMGATePVGLTCAVILEEGFPRGDLERVVASMRETAKEAGAPFVTGDTKVMGKGqvdgIVLNTTGVALADrvvsd--agl 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                         ##             
2Z1T_A       163 rpGDAILISGSMGDHGLTILSQRQg-lNFAADVCSDSASLNRVVEKLVlev-----gdiHVLRDPTRGGLAttLNEIAgq 236
2Z1U_A       163 rpGDAILISGSMGDHGLTILSQRQg-lNFAADVCSDSASLNRVVEKLVlev-----gdiHVLRDPTRGGLAttLNEIAgq 236
gi 119720516 173 rgGDKIVVTDYVGDHGAVILMLQMg-mGDVEEIASGSLKSDSKPLTPLlpvfekfagyiHAARDPTRGGLAgvLNEWArs 251
gi 145591522 167 qpGDKIVVSGYLGDHGAVILARQIg-iIDEGSGGGLVSDVKPLTRLMLplvek-ygphiHAARDPTRGGLAmaLNDWAka 244
gi 124027900 179 rdGDKIVVSGYLGDHGAAILSVREg-iGLKLEVESDVKPLTDLMIPLIerya----dyiHAAGDPTRGGLAmlLNDWAkk 253
gi 170174817 168 kpGDKLIVTGTIGEHGAAILSAQEg-iAVEGKLESDVNTLSKLMLPLLgayg----dkvHAAQDPTRGGLAqtLNEWAqk 242
gi 126464925 168 kpGDKIIVTGPIAEHGATILAAQLgmlEQAQGLRSDTRPLVKTVLPILekyr----dhiHAARDPTRGGLSivLNEWVrg 243
gi 126460174 166 reGDKIVVTDFVGDHGGVILANRL---GLEANIISDVKPLTNLLPVLEkyr-----pyiHAARDPTRGGLAmvLNDWAka 237
gi 156937284 164 epGDKVLVTGPVGDHGATILALQFg--LQVKTLKSDVRPVWPAVKALRealg----edlKAAKDPTRGGLAmaLNELAer 237
gi 163765534 167 raGDLLVVTGSIGDHGMAVMARRHd-lRLEGDLRSDVAPINGLVRAALaagg----edvVAMKDPTRGGVAgvLHEMAak 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                                                                             
2Z1T_A       237 sQAVCHVLETAVPVRESVRNGCSFLGLDPLYLANEGKLICILpeeraEAALAVLregphgeHAARIGSV 305
2Z1U_A       237 sQAVCHVLETAVPVRESVRNGCSFLGLDPLYLANEGKLICILpeeraEAALAVLregphgeHAARIGSV 305
gi 119720516 252 gGLLAVIREEEVPVRDAVRRFAEMLGVDPLYLASEGAAVLSVspevaEEVVSELrgr-gfpNARVIGEF 319
gi 145591522 245 sGTVIIVEESAIPIRPQVAYYANMLGIDPLALASEGAAVLSVspdvaEEVVEFMkkl-gfdNAAIIGEV 312
gi 124027900 254 nGLVIAIDEAKIPVREQVRAYAELLGVDPLALASEGAAVLAVdplmaEEVVEFMrsl-gyeEATIIGEV 321
gi 170174817 243 sGLFILVEERKIPMRDDVRAFTELLGIDPLALACEGRAVLGVegdsaEDVLSFIkel-gyeEASIIGEV 310
gi 126464925 244 tKYTIVINRSTIPIRDEVRQFLDALGIDPLGVAGEGLAILSVdnevaDEIVEELhrr-gepYATIIGEV 311
gi 126460174 238 tDTVIVIDQGRVKVRDSTRAIADMAGIDPLYLASEGVAVLAVdttvaEEVVEELkka-gfpEAYIAGEV 305
gi 156937284 238 sKTTVYVEEARVPIREAVKEYAEMLGVEPLALASEGQAVFVVkgdraEEALEVLrka-gfeEAAIIGEL 305
gi 163765534 242 gGVGIVVDEPSLPVNDEVRAAGEMIGIDPLLVANEGKAVIGVrarsaDKVLAALrahplgaRATVFARA 310

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