Conserved Protein Domain Family
YjgH_like

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cd02198: YjgH_like 
Click on image for an interactive view with Cn3D
YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Statistics
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PSSM-Id: 100005
View PSSM: cd02198
Aligned: 20 rows
Threshold Bit Score: 129.689
Threshold Setting Gi: 58261434
Created: 8-Feb-2005
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
homotrimerputative active
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:homotrimer interaction site [polypeptide binding site]
Evidence:
  • Comment:based on similarity to other members of the superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          ##  # #       # # ##                                            # ## # #      
1PF5_A        19 HRYSAAIRSGd-----LLFVSGQVGSredgtpepdFQQQVRLAFDNLHATLAAAGCTFD-------DIIDVTSFHtd-pE 85
gi 17549565   32 FNYAPAVAAGg-----LLFIAGQIGIradgtvpasVEEQIDLAFQRLGAILQAAGLGFE-------DLVELVSYHvd-vD 98
gi 86139345   18 LALSPGVLSGe-----HLFLTGMTGSeasgempddPEQQFRNAFAKIGAVLAEAGLDFS-------SIVEMTSYHvg-mS 84
gi 28869670   19 AGYAPAVRVGd-----TLYCAGQVGRtrdmevilnPEAQFIACWENLRTVLAEGGCTFD-------DIVDMTTYHva-mS 85
gi 58261434   18 DNFAPAAAVIlpanakTLYISGVVGEnedg-sfgdFRTQVFLIFDRITEILLNASPSYKsagnawkHVFEITAYHvgplP 96
gi 85709249   56 FGFSEAVIHGd-----TVYLSGVILGppqe--getQEEAFDRTFQYIGGILERAGSSWG-------DVLDITTYHtd-iD 120
gi 87201102   10 FGYCAARAAGg-----LLFCSGQIGLeadgsvpeaASRQFDMAFAALAETLEQNGCATS-------DIVDLTSFHvg-yP 76
gi 89053600   19 WHMSPGLMVGd-----FLFLTGMTGAgpdgivdpdPETQIRLAFQRADAVLQEAGLSFA-------HVVEMTSYHvg-iA 85
gi 89055571   19 YHYAPGILVGd-----TLYCSGQVGRdadlnvvdgPEAQFTQAFENAGKVLAAAGASFD-------DVVELESWFag-sM 85
gi 115361321  19 IGYAPAIKVGd-----TVYVSGQIGRdaamqlvedREAQIVQAFENLKRVLEAGGASLD-------DVVDLTTFHt--dM 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
Feature 1              #  #   #    #########           # # #   
1PF5_A        86 NQFEDIMTVKNEIFsapPYPNWTAVGVTWLa---GFDFEIKVIARI 128
gi 17549565   99 RQLAAFRETKDRYIk-eGAPAWTILGVAALar-pTLLIEIKAVAAT 142
gi 86139345   85 DHFDLFTEVRRDYVc-ePFPAWTAHGVAELrr-pGAVVEIRVIAQK 128
gi 28869670   86 EHMPVFRDVKNRIFp-rGQCAWTCIGVAELah-pGLLLEIKCIAVR 129
gi 58261434   97 EHLPIELEAVDKYLk-gAHPTWTSAAVEKLfh-dEQLYEVHVKAIV 140
gi 85709249  121 ASMPALAAVKNRYVk-aPFPAWTAIDVDRLya-pEGVVEIKITARR 164
gi 87201102   77 AHMEEFAKAKAAFLd-gATCCWTAIGVASLgy-pGSLVEIKAVATR 120
gi 89053600   86 SHIDAFRAIRSEYVa-aPHPAWTAIEVAGFvt-pGTVCELRIVAHR 129
gi 89055571   86 DELKTFMAVKDRFFk-hRYPTWTGFSVNGFsm-pGILVEIKCKAIL 129
gi 115361321  85 RDLPLFLQVRDRYFhahPRPAWTAVGAHMLggspGYIVEIKAVAVL 130

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